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L-methylfolate + other cofactors. Necessities?

JohnBoy2000

JohnBoy2000

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After reading the section in Stahls book, as well as the miracle reports on drugs.com about this, I've decided to try this as an addition.

It's not available in high dose "Deplin" here, but I can get about 120x 1 mg pills for a reasonable price.
So I'll just like, stack them to make the necessary dose of 7.5 or 15mg.

The other suggested cofactors were methyl-B12, active B6 - pryridoxal phosphate, tyrosine, and possibly SAMe.

But, my diet is very good.
I certainly can't imagine I'm low on B vitamines.
A dietary source of tyrosine?
I don't even know.
Like I said, my diet is super clean and balanced.

L-methylfolate - its even mentioned in Stahls prescribing guide, but he doesn't mention any additions that need to be taken with it.

Does anyone have insight/experience with these?
And/or literature links that can give me more insight into what, if any, combination of the above must be taken for best effect, or whether the L-methylfolate in itself is enough.
 
A lot of the clinical trial data is l-methylfolate in combination with the initial drug, SSRI etc, and seems to demonstrate a high level of efficacy (why is it not a mainstream adjunct???), but does not mention additional adjuncts like tyrosine or methyl-B12.
 
I can not find any research on google scholar demonstrating that l methylfolate or even folic acid can produce a positive result or known interaction implicated in depression at doses below 10 to 50 mg per kg making it unlikely sufficient quanties could be consumed. I am skeptical. Also, I have tied same, l tyrosine, b 12, and pyroxidine phosphate and I found them to be inactive compared to say amphetamine. If your not severely deficient in vitamins or protein I doubt taking in anything additional will have an effect.
 
* in rats if the effect is real it should be demonstrable in both rats and humans. And, itsich harder for rats to have a placebo effect or bias.
 
d1nach said:
* in rats if the effect is real it should be demonstrable in both rats and humans. And, itsich harder for rats to have a placebo effect or bias.
Click to expand...

But
you mention there's not been trials on rats?

When you say you tried same - SAMe, methyl B12 etc - did you include methylfolate with that?
 
Yea 1 mg sublingually. If your deficient in it though itll work amazing. Andin rats not trials recetor tests where they gove drugs or disect brains.
 
In my opinion for me the right nutrients vitamims and minerals are kinda like trying tp build a faste r better computer you they are like the nuts and builts if your missimg one yoiur entire computer might not work or be extremely messed up and you can try to download any fancy program you want it wont work without first adding that missing factor nutt back. But once its in place having extra nuts wont do anythimg because u have no use for them. Idk if that made sense lol
 
No I mean - I'd would seriously question if I lacked in B vitamins.

But regarding the methylation process - that may not depend on diet.
I had the bloods for homocystein taken so, I guess they'll be indicative on some level....? When the results come in.

Perhaps taken l-methylf is worth a shot, given the miracle responses some people have.

That being said, I have responded to noradrenergics in the past, almost immediately.
As in, on the first dose.

Last night, I took Lofepramine for the first time, 70mg - the starter dose.
Today, was a good day.

I mean - mood is not a complaint for me. I don't feel up, or down.
Functionality is the issue.
And today, there was most certainly a very evident improvement.

How methylfolate may play into that in the coming weeks - I guess has yet to be determined.

But I guess it won't hurt to pony up the 50 powends for couple jars of l-methylf, and dose for a month or so to see what happens.
 
I think my mom has a prescription for l methylfolate. Idk if you have insurance but if you have a zero dollar copay that may be cheaper.
 
Reading web reports of this, some articles hotly dispute its potential benefits - then some anecdotal reports claim that after, all sorts of AD's, ECT etc to counter depression, suddenly they start taking l-methylfolate, and their symptoms clear up.

As well as - high doses are just not available here in Europe.
The max dose is 1 mg.

I mean - I know there's some deviants in the pharmaceutical industry, but such a potentially profound cure to such a widespread illness - could this be overlooked to that extent?
 
I agree with burn it up. My mom had he taking it at one point because she thought itd help id jist take and smile thank her cause i love my mother very much and she means well. To put things in perspective she thought it was a miracle too. Then she tried adderall for her fatigue and she couldnt believe how strong it was. People believe in many things. It could work but i just dont have enough research papers available to me to say it doesnt. Vitamins can have profound effects for example niacin in megadoses for stroke or fishoil for vascular issues but big pharma didnt try to bury any evidence or call it bs instead they saw dollar signs and quickly sold you their niacin and their fish oil faster then you could blink
 
JohnBoy2000 said:
I mean - I know there's some deviants in the pharmaceutical industry, but such a potentially profound cure to such a widespread illness - could this be overlooked to that extent?
Click to expand...

I don't think clinicians overlook the important of a good diet (I.e folic acid), but the *minority* that may benefit from methylfolate could have abnormal genetics. That is to say that any number of nutritional deficiencies could contribute to depression but it's probably not very applicable to the majority of depression sufferers.
 
I agree missing vitamins or minerals can cause depressive sympotms. However, major depression is a seperate disorder and any vitamin or mineral deficency can be objectly quantified with blood work rather than relying on vague symptoms. And, the majority of people in developed countries are not vitamin or mineral deficient even if they eat a poir diet. The health benefits associated with a healthy diet is probably not related to vitamins and minerals as given them as supplements in the abcence of a change in diet does not consistantly tomy knowledge produce results better than chance
 
I believe the DSM is currently operating under the diagnostic criteria of symptoms rather than Biomarkers or biological/genetic correlates of a disease, meaning that depression is more of a syndrome in the sense that it is diagnosed as a collection of symptoms although it certainly is a biological disease (with many differing causes). But I do agree that if vitamin D deficiency etc. has caused depressive symptoms then I would think that would be addressed as primary nutritional deficiency and then secondary depression. But the biology specifically associated with depression could probably be seen with a nutritional deficiency, tryptophan deficiency for example. If the nutritional deficiency leads to persistent depressive biology I should think that that should still be diagnosed as MDD if the criteria are there after the nutritional deficiency has been corrected.

One issue with the DSM as that many people have co-morbid diagnosis, while it may be better to research the biology and do trials with a more encompassing view. For example, if someone has comorbid depression and anxiety, I don't know if finding a drug efficacious for depression then finding a drug efficacious for anxiety and giving it to the population at large would be the best way to do things. It might be better for doctors to look at trials specifically with people who had depression + anxiety, as that could be a distinct entity although the symptoms overlap. Existing or previous nutritional deficiencies + depression could be a distinct entity as well I suppose.
 
Ya i mean that depression is based on symptoms but vitamin and mineral deficiency are based on measured levels in you. Otherwise people could sell you vitamin c for depression becuse we gave it to pirates and their mood sky rocketed.
 
For exmple if we went my symptoms to figure out if we are folate deficient do you have
Loss of appetite and weight loss can occur. Additional signs are weakness, sore tongue, headaches, heart palpitations, irritability, and behavioral disorders

That could be anyone. I have all those and arent folate deficient
 
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