I've wondered about this myself in regards to differential response to SSRIs and the serotonin portion of MAOIs .
It appears that the expression of SERT is not just dependent on brain location but the time of development as well
http://www.ncbi.nlm.nih.gov/m/pubmed/27282696/
http://www.ncbi.nlm.nih.gov/m/pubmed/24904298/
https://www.ncbi.nlm.nih.gov/core/l...om&p=PMC3&id=4032978_fncir-08-00052-g0003.jpg
^Helpppppp S2A, is that slice showing increased SERT expression more towards the cortex?
There are also apparently neurons that absorb 5-HT through SERTs but they do not synthesize any themselves
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153855/#!po=0.920245
"Serotonin absorbing neurons use serotonin reuptake transporter to uptake serotonin from extracellular space but do not synthesize it.
Loss of mod-5/SERT function blocks the 5-HT absorption. mod-5/SERT mutants have been shown to exhibit exaggerated locomotor response to food deprivation. We found that transgenic expression of MOD-5/SERT in the 5-HT-absorbing neurons fully corrected the exaggerated behavior. Experiments of cell-specific inhibition of synaptic transmission suggest that the synaptic release of 5-HT from the 5-HT-absorbing neurons is not required for this behavioral modulation. Our data point to the role of 5-HT-absorbing neurons as temporal-spatial regulators of extrasynaptic 5-HT.
Regulation of extrasynaptic 5-HT levels by 5-HT-absorbing neurons may represent a fundamental mechanism of 5-HT homeostasis, integrating the activity of 5-HT-producing neurons with distant targets in the neural circuits, and could be relevant to some actions of SSRIs in human."
What the hell 0.0 Also sorry to derail thread.