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(CPM/24mg, DXM/180MG, TERBINAFINE/75MG) - I'm glad this isn't the shrine o-o

Ventrusii

Bluelighter
Joined
Jun 26, 2016
Messages
146
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Till the roof comes off, 'till the lights go out,
DISCLAIMER: Coricidin conatains Chlorpheniramine Maleate, which can cause effects anywhere from annoying, to harmful, to deadly. Please use caution when using Coricidin, and if possible, find a DXM-Only product.

To answer the questions that are sure to come and please, if I answer your question with any of these answers, don't ask the question please. 1) I know, I'm stupid. I didn't remember at the time that inhibition of an enzyme can also cause increase in concentration, not just length. 2) Yes, I am an idiot. 3) How'd you know, I am a minor. That shouldn't matter, fuckwit. 4) Yes, I know CPM can cause seizures at high doses. 5) I (Used to, mind you) take 32mg CPM each time. 6) I inhibited CYP2D6 to try and potentiate DXM's SNRI activity, without DXO's only-NRI-activity.

Great. Now that that's through with,
Full story:

Some lonely and saddening night a while back I decided that I wanted to try and get more bang for my buck with DXM for what I was using it for and inhibit CYP2D6, so to increase the amount of DXM to DXO. The inhibitor for CYP was Terbinafine, an old anti-fungal medicine I found and kept away for a time like this. It is a potent CYP2D6 inhibitor, so i used about a third of a 250mg tablet that probably was a little less, so I'll call it 75mg. I used this with 6 CCC's, and little did I know this would be the worst decision I ever concisously made.

It was "eh" at first, nothing but habits that i recognized as very non-DXM like, I found myself talking to myself in my head a lot and had a minor headache, which I either never feel or experience on DXM. But after the T+3:00 mark, I knew for a fact something was very, very wrong. I felt no happiness, and this was my first alarm bell. I can get a very lifted mood off of 60mg, why not at ALL on 180mg? Second, I recognized my pattern of thought as that of the time I experimented with DPH, I was jumpy, paranoid, and pacing.

It hit me like a brick wall what I'd done, and i knew that since CPM was an anticholinergic, that some if not most of the bad effects would be caused by this. I promptly broke open a fresh package of Alpha-GPC 50% and took one gram, another an hour later as well, and also ~20mg of Noopept sublingually. I was freaking out at this point, but somehow very able to discern hallucinations from reality. Not in the way that they were discernable, to say, but that i was able to run through the "is it possible" logic sequences for all the noises I heard. I heard people talking to me that was just the kitchen oven fan, as well as the "TV" that was only the AC. My pupils were bigger than they get on DXM usually, due to the Anticholinergic effects, and I was flushed, not sweating, paranoid, heart racing at like, 140-150 normally and 180-190 during my panic attack. The panic attack came at about the peak of the come-up, so to speak. I was texting my drug-experienced friend about the whole thing but didn't detail what I took, just said something very stupid, and he helped me through it. I told him at one point througj text that I just narrowly avoided calling 911, and he called me seconds later. I explained that i just felt a cold flash, but I must have sounded insane because he had no idea the stuff I was on increased my anxiety 100-fold. I have no idea whay happened to this day, i did feel a cold flash, but the thing is I was looking in the mirror as it happened and my eyes went from barely any color to the size they are when I take opiates. I screamed out loud (thankfully no one was home) and had the first panic attack I had had in years. I looked up cyp2d6 inducers and found that valerian and sage (I think?) Were cyp2d6 inducers to some extent, so i took lots of valerian and sat in my bed on my computer trying to wait out the terrible night that was about to come. I browsed bluelight a lot, and saw that every picture seemed to "talk" to me, without audio. Like, someone's pic had a guitarist on it and the guy in the picture looked at me, put his guitar down, and started waving and mouthing words at me and I found it so amusing. I also saw the white background of posts and for some reason, a clear pattern of houses started appearing, as if part of the background. I also saw the "breathing" visual effect for the first time on CPM, when I looked outside it was amazing, trees, the ground, and even the fences were breathing. By this time, I had calmed myself down enough not to enjoy it, but to be sane at least.

--> TL;DR - took 24mg CPM and 180mg DXM with potent inhibitor and noticed shortly in something was off, anticholinergic poisoning comeup insued and due to the fact that it was CPM of all anticholinergics, I was scared shitless.

As the title says, I'm glad this isnt the shrine. I'm glad that I'm the one typing this up and not someone who knew me and wanted to remember me.

A question for anyone reading, does CYP2D6 inhibition cause increased plasma levels of CPM or just longer duration?

Tagged by Xorkoth
substancecode_coricidin
substancecode_chlorpheniramine
substancecode_dxm
substancecode_deliriants
substancecode_terbinafine
_combo_
explevel_experienced
exptype_negative
exptype_healthissues
exptype_bodyload
exptype_difficult
roacode_oral
 
Last edited by a moderator:
CPM is also an SNRI and therefore may not be that safe when doses of CPM and/or DXM are larger - another reason not to combine in recreational amounts let alone adding cyp inhibitors. It has a long half life to begin with and terbinafine does too... so if it was really the anticholinergic effects you would expect that you experienced this for many many hours like up to a day. I would also expect relatively more of a longer duration and also increased plasma levels (compared to without any inhibitors of course), but less so. If the half life of CPM was much shorter I would expect more of a relative increase in plasma levels because of all the CPM that then isn't metabolized rather quickly.

As a rule, never fuck with your enzymes unless you strictly know all the ins and outs of all the drugs and foods etc you ingest during the time. But honestly, I don't think there is a good reason why messing with liver enzymes is necessary with all the options, well maybe some moderate GFJ in some cases but that's about it. DXM has very complex action and is not forgiving if you fuck up.
If you have few options yet, go on the hunt for real ones... don't settle for options that really aren't ones.

Glad this isn't the shrine, yes.
 
Hey, thanks for sharing. You sound like a smart kid, recklessness aside. Given that, I really strongly recommend that you quit using Coricidin for DXM, and get something with DXM only. I'm not knocking you... I used to use Coricidin too. That shit is bad, and the effects are less pleasant anyway.

I'm also glad this isn't the shrine.
 
CPM is also an SNRI and therefore may not be that safe when doses of CPM and/or DXM are larger - another reason not to combine in recreational amounts let alone adding cyp inhibitors. It has a long half life to begin with and terbinafine does too... so if it was really the anticholinergic effects you would expect that you experienced this for many many hours like up to a day. I would also expect relatively more of a longer duration and also increased plasma levels (compared to without any inhibitors of course), but less so. If the half life of CPM was much shorter I would expect more of a relative increase in plasma levels because of all the CPM that then isn't metabolized rather quickly.

As a rule, never fuck with your enzymes unless you strictly know all the ins and outs of all the drugs and foods etc you ingest during the time. But honestly, I don't think there is a good reason why messing with liver enzymes is necessary with all the options, well maybe some moderate GFJ in some cases but that's about it. DXM has very complex action and is not forgiving if you fuck up.
If you have few options yet, go on the hunt for real ones... don't settle for options that really aren't ones.

Glad this isn't the shrine, yes.

-I didn't know CPM was an SNRI, so thank you for bringing this to my attention!
-I experienced what is considered STRONG anticholinergic poisoning from about 10PM friday (the day of this whole endeavor) to about 8 or 9AM the next day, and then mid to low poisoning from then until Monday morning. I was still very jumpy even at the end of Sunday.
-I have access to a low but good selection of other stuff, It's just that it's what I actually prefer.
-"Glad this isn't the shrine, yes." Thank you, Solipsis :P
 
Hey, thanks for sharing. You sound like a smart kid, recklessness aside. Given that, I really strongly recommend that you quit using Coricidin for DXM, and get something with DXM only. I'm not knocking you... I used to use Coricidin too. That shit is bad, and the effects are less pleasant anyway.

I'm also glad this isn't the shrine.

Well thank you for the compliment, in contrast to the whole situation that makes me think I'm dumb enough to end up in the Shrine :P (and I am NOT saying that everyone or even most people in the shrine are there due to stupidity, I'm saying stupidity can land you there much more easily) , and yeah I can be reckless at times. I only consider myself to have done something like this, that was "beyond-a-reasonable-doubt something only someone with intentions to overtly be an idiot would do" about 4 times. This has to be the worst of them (or maybe tied, I'm writing the other story up right now).

About knocking CCC's for DXM, I pretty much did, I used them for a while when I first started using DXM and when I was an idiot and received 12 packs more that was essentially when I decided, and for about a month I've used the stuff for DXM maybe 3 times. I'm glad I got them and realized I shouldn't have, I guess, because I used to use the stuff every 3 or 4 days (DXM, not CCC's).

"and the effects are less pleasant anyway." I agree, but nonetheless I always loved the incredible amounts of novelty enhancement that came with it. I know, I know, the fact that CPM causes novelty enhancement is a bad effect in itself, but I'm just saying, not debating, I agree that it's worse overall.

"
I'm also glad this isn't the shrine." Thanks Xorkorth :P
 
You sound very knowledgeable about drugs and there mechanisms which is uncommon for people your age. Glad you are okay and definitely stay away from triple C's go for the dxm gels �� also I'll add to what others said, glad this isn't in the shrine.
 
Agreed, you got plenty of smarts. And people do make mistakes. :) I've been foolish myself, but I guess rather with abuse and unknown risks of novel chems than disregarding the warnings of drugs with known health issues like that. We don't really get to choose what we want, but in my experience what can make a difference is realizing how some options we have regarding drug use are not real options at all, which can make it easier to just stop considering altogether.

I wouldn''t be so presumptuous to say anything about preference for DXM. People react more varied to DXM than to most other drugs, probably because of individual metabolism... just don't consider CCC or enzyme inhibition real options in the future, please.

Use your smarts to learn from the mistake and avoid pitfalls of intelligence like typical forms of stubbornness among other things. Just a general tip since I've seen it before, knowing a lot about drugs and mechanisms of action isn't necessarily so ideal. :)
 
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