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  • BDD Moderators: Keif’ Richards

Are there any legitimate ways to enhance Oxycodone?

T

Tboy246

Bluelighter
Joined
May 6, 2016
Messages
52
Enhance as in lengthen the duration of the high.. My friend already knows about grapefruit juice and tagamet but has heard that those can actually take away from the high slightly by preventing conversion to oxymorphone and so forth.. So is there any other ways and do u personally think grapefruit juice and tagamet is worth it? Thanks!
 
Theres a whole long thread on here called the opiate potentiation megathread, enjoy
 
 
Clonodine and promethazine run a close race for the best for me but the only issues are that these are Rx medications so not always easily available. Your cheapest and best option is to go to your closest gas station and but one envelope of the Goody's powder (like for a headache) in the blue pack. MAKE SURE it's the type that has caffeine. Take one dose of the Goody's powder while coming up and another when you feel yourself coming down. It should improve the peak as well as adding another hour or sometimes more on an empty stomach
 
Tboy246 said:
Enhance as in lengthen the duration of the high.. My friend already knows about grapefruit juice and tagamet but has heard that those can actually take away from the high slightly by preventing conversion to oxymorphone and so forth.. So is there any other ways and do u personally think grapefruit juice and tagamet is worth it? Thanks!
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Check out some of our Opiate Potentiation threads and you'll find some interesting stuff. I'll be bold and say that you're not going to find anything better than what you are using and everything you have listed is going to bring about a minor change in how powerful the Oxycodone feels. Benzodiazepines are a common choice. Just be sure to tread lightly with your dosage, as the combined use of Opioids and Benzodiazepines creates synergy or a high equal to more than the sum of its parts so to speak.
 
FYI enzyme inhibitors don't take away from the high by preventing conversion to different opioids--they just slow down that process. They'll modestly extend duration but they shouldn't do much to alter the high. Cimetidine is another option.
 
THC and/or low doses of benzos (klonopin, Xanax, and valium were always my favs). It really comes down to your tolerance to oxy and other things that potentiate oxy and figuring out how much of what you need together to feel a good buzz. IME though smoking good bud and taking one of those three benzos I mentioned makes all opiates/opioids MUCH stronger, oxy being the one I used the most during my time addicted to opiates. Grapefruit juice does indeed potentiate oxy too, for me at least, just not nearly as much as other actual drugs.
 
It was asked specifically to extend duration, so other than re-dosing, an inhibitor is probably the best way to go. However, it is unclear if intensity will differ as Keif mentioned.
 
There is a non opioid pain killer caller flupirtine that works amazingly. Really boosts the analgesic effects. Soma is great also Semax can slow the breakdown of peptides like Endomorphin-1 and Endomorphin-2 which makes the effects last longer
 
The compounds in grapefruit juice (furanocoumarins) don't inhibit the CYP2D6 enzyme - so no, it doesn't in any way inhibit the action of oxycodone. It's a myth. The actives irreversibly inhibit the CPY2A4 enzyme which is responsible for the N-demethylation of codeine, hydrocodone, oxycodone and I suspect ALL of the phenanthracene class of opioid. I just think that with potent things like oxymorphone, it's gluconation that limits duration so likely isn't as notable.

But I'm really not sure if potentiation of opioids is really a good long-term plan. I've known people who now have to drink 1L of grapefruit juice (or grapefruit skin extract equivelent) because they tricked their body into expecting more and for longer. I mean these people got sick without furanocoumarins!
 
oxy goes great with temazepam i used to get scripted both at one point. Promethazine also boosts it
 
ye same with all opiate promethazine i tell all my friends and anyone who listens promethazine is like a wonder drug it does all(or atleast most) of the things benzos does but without the horrible addiction
 
Promethazine is capble of profucing addiction - I've seen it, typically in those on methadone maintainance. It certainly produces a specific AWS.

I mean, who knows what doses these people are consuming or for how long, but chronic use of any CNS depressant will eventually see changes in body chemistry - homeostasis being what it is.

Promethazine also doesn't seem to potentiate all opioids eequally - again, it's methadone it seems to really affect. I've seen people on methadone get trashed by the same dose they had been taking for months. I seem to remember a study that found almost 50% of people on methadone maintainance in the US were also consuming promethazine. I've not seen that figure associated with any other opioid... but just because a study doesn't exist doesn't mean the issue doesn't exist.
 
paranoid android said:
oxy goes great with temazepam i used to get scripted both at one point. Promethazine also boosts it
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Temazepam on its own is probably better then a low dose Oxycodone on its own.
Like 10 mg of Oxy vs 10 mg Temazepam. So no wonder.
Overdue, and your down-under but, otherwise great combo i imagine.

Promethazine on its own is a nightmare, i doubt it could improve Opioid s.
But according to junkies it might. Solely its shite, so i advise keep the dose low as possible.
Which also counts for Temazepam, you don t wanna die, so keep the doses minimal.
 
It is a surprise for me to see that people like temazapam. I had it prescribed once and even at prescribed doses, I felt like I was borderline going to get restless leg syndrome. Ugh!
Although it does occur to me that maybe I was taking it at a time when I was taking Prozac and there could have been an interaction. 🤔 Or with something else.
Regardless, I threw it away, I hated it. But I never had that problem with other benzos
 
Should probably add that promethazine can cause tardive dyskinesia like anti psychotics and it's irreversible once it reaches a certain point. It affects the same brain receptors and if you research it it'll tell you.
 
Thankful_for_this_place said:
Should probably add that promethazine can cause tardive dyskinesia like anti psychotics and it's irreversible once it reaches a certain point. It affects the same brain receptors and if you research it it'll tell you.
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I keep finding terms such as 'accociated with consumption of promethazine' or 'promethazine may patentially cause'. I suppose because a POTENTIAL risk is known, it ironically prevents from performing a human study into promethazine use. Because all human studies are legally required to be ethical. Think about that for a moment - it took legal action to make pharmacutical companies test in an ethical manner.

Anyone else old enough to remember the fallout caused by thalidomide? Or, more recently, the 'Super MAB' scandal in the UK. Or internationally Pfizer testing a novel antibiotic on Nigerian children (in the city of Kano to be exact)? Even before that experimental HIV medications were given free to people who took part in the trial. Pharmacutical companies all apply 'the rule of poverty'.
 
4DQSAR said:
I keep finding terms such as 'accociated with consumption of promethazine' or 'promethazine may patentially cause'. I suppose because a POTENTIAL risk is known, it ironically prevents from performing a human study into promethazine use. Because all human studies are legally required to be ethical. Think about that for a moment - it took legal action to make pharmacutical companies test in an ethical manner.

Anyone else old enough to remember the fallout caused by thalidomide? Or, more recently, the 'Super MAB' scandal in the UK. Or internationally Pfizer testing a novel antibiotic on Nigerian children (in the city of Kano to be exact)? Even before that experimental HIV medications were given free to people who took part in the trial. Pharmacutical companies all apply 'the rule of poverty'.
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Well seeing as it's been around a helluva long time and an official side affect is listed as uncontrollable muscle movements.

https://www.drugs.com/promethazine.html#side-effects

I would think 🤔 officially having it listed is because it was a regular occurrence over the time since it was made which was the 1940's. So I just think 🤔 people should have the information of potential serious, irreversible side effects they could be exposing themselves to. I would think 🤔 anyone who is giving information out on here liberally would research before they dismiss it. It would have to have been enough of an impact for 85 years to be listed on reputable sites. Because there's plenty that list it. It may not happen to you but what if you could prevent it from happening to someone else? Denying it doesn't change the facts available

Movement Problems. Promethazine may rarely cause involuntary movement problems, including shakiness, stiffness, or jerkiness. Call your healthcare provider right away if you develop any unusual or uncontrolled movements.

Courtesy of WebMD 👆🏻

It affects the same brain receptors as antipsychotics. D receptor. Just everyone do your own research and be informed and decide for yourself after you read all the information you can. That's my only purpose is to give information I took the time to research myself
 
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Well, I tend to go for the academic papers. I'm not saying you are wrong, I just said that we are in the position of not being able to confirm what we (strongly) suspect.

Like it a side-effect seen in a minority of patients or is it simply the case where everyone is equally at risk?

I did indeed do quite a lot of research and I quoted directly from the academic papers. You can have them if you want them.

BTW simple question for you - if all of this is so obvious, why is promethazine still in use? In fact why is it still just a [P] medication in a lot of nations? If it produces such terrible side-effects on EVERYONE who consumes it, why is it still in use? Think carefully - there are almost certainly multiple conflicting reasons.
 
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