4.6 milligrams is a very high dose. Not to the point that I recommend avoiding it for safety concerns... But be aware that you'll likely be in for a very physically rough, and certainly a very long, ride.
I personally can't handle the side effects past 3mg, or maybe a bit over that. I also find that the side effects tend to correlate with my relative level of physical fitness at the time. Ie. I'm much better off on DOC in the summer when I spend a lot f time outside and physically active, than the rest of the year when the majority of my hours are spent in front of a computer or in a laboratory. Hopefully you're in good cardiovascular shape. If so... I'm sure you'll have a great time. If not, you'll probably still have a good time.
Keep in mind that physical activity makes the come up feel a lot easier, and also does wonders to reduce the discomforting vasoconstriction and muscular tension--the dose might feel sufficiently overwhelming the prospect of moving around and "doing something" might seem daunting during the come up and peak, but if you can build that into your day plan you'll likely be glad you did. (On the other hand, it's incredibly easy to exert yourself far past your normal limits on psychedelics in general and on DOC in particular you'll literally feel like you have superhuman strength and limitless endurance--exertion just feels like nothing at all. Just remember that the same rules apply as for amphetamines: watch that you don't push your heart rate too high, make sure that you're taking care of your physical needs like food and water, and be aware that if you push yourself too hard you'll certainly feel it later.