Could someone with experience with both tell me the differences between Clonazolam and Flubromazolam – are they similar to each other, equipotent, to come to an End: is this Benzo really so much different when compared with those i'm experienced with, or are these just minor! Thing is, i'm not really a Fan of Benzos, as their effects are too subtle for recreational use and too dangerous to take regularly, so it's important to know what makes Clonazolam so special?
Oki doke, lets see if I can make sense, Ill give myself a 50/50 chance at this stage. I have no in depth knowledge of psychopharmacology so perhaps Sprout or someone will correct me in necessary.
There are a number of different subtypes of benzpdiazepines, for instance, for example, the 7 - nitro group of benzos contain some of our pharmacological favourites including Clonazepam (Rivotril / Klonopin), Flunitrazepam (Rohypnol) and Nitrazepam (Mogadon). Diazepam, the gold standard of benzos, belongs to a different subtype, the 2 - keto group.
The the drug Triazolam (Halcion) was first patented in 1970, it was the first example of a new subtype of benzodiazepines, the triazolobenzodiazepines, or triazolos. The inclusion of the triazolo structure within the molecule produced an ultra - short acting, potent benzodiazepine that was extremely active at sub milligram doses (0.25mg of triazolam = 10mg diazepam). As this was the first drug of its kind, it gave its name to this subtype of drugs/ The most common triazolobenzo in medical use at present is probably Alprazolam (Xanax). You can tell the difference between triazolo benzos and other subtypes due to its name - most benzodiazepines end with 'pam' at the end of their name as a pose to the triazolos whose names tend to end with 'lam' (this is not a hard and fast rule as the Imidazo subtype of benzos also often end with 'lam', Loprazolam and Midazolam being good examples.)
Now we have that out the way ill describe my experiences with the 2 most popular triazolo NPS benzos, Clonitrazolam (Clonazolam) and Flubromazolam.
Clonazepam has always been my favourite pharm grade benzo due to the the potency of the preparation (they come in 2mg tablets which are equal to about 30mgs of diazepam), their long acting duration and, of course, the wonderful benzed effect they produce, broad in spectrum but not overly sedating which makes them ideal for daytime use.
When it comes to NPS benzos Flubromazepam quickly became my favourite, despite the problem with its duration which I have described above.
NPS chemists eventually produced 'triazolo' versions of both the drugs I have described above. By altering the drugs molecules in this way it would be expected that the resulting drugs would be somewhat similar to their non 'triazolo' parents, only both subjectively stronger and more potent by weight and with a shorter duration of action.
Clonitrazolam was the first I tried and found the effect wonderful and almost as good as flubromazepam in terms of the almost euphoric lovely anxiolytic effect they produced. They felt similar in some respects to Clonazepam, only they were markedly more sedating and required about half of the dose to produce a comparable effect. As expected, the duration of action was shorter than that of Clonazepam, taking effect within 15 minutes to an hour and lasting approx. 12 hours, classifying them as an internediate acting benzo. (Clonazepam is classed as a long acting benzo, admittedly one of the shorter acting, long acting benzos with an average duration of affect between 18 - 24 hours).
Flubromazolam then of course is the 'triazolo' version of flubromazpam, and despite reporting my experiences before on Bluelight I will repeat them here due to the unusual reaction I had to this particular drug. As a child of the extremely potent flubromazepam, I had expected this one to be hyper potent and these suspicions were confirmed when the first trip reports came in - the drug was so potent it was sold in doses of 250mgs layed onto blotters as well as acting as the active ingredient in vendor pressed pellets. I got 25 as a tester and took 1.25mg as an initial dose (I have a silly high tolerance to benzodiazepines - despite using them 2 -3 times a week max nothing with an equivalence lower than that of 50 - 60mg diazepam will touch the sides).
Flubromazolam - 1st dose - 1.25mg: Took about 20 minutes to take effect after which I was literally crawling around the carpet. I have to say that they blew my head off, giving me one of the most potent benzo experiences I have ever exerienced.
2nd Dose - 2 days later. I took 2mg (silly I know) but rather than knocking me sideways they had much less of an effect, perhaps equivalent to 40 - 50 mgs Diazepam. ??? I had hear that f-LAM was notorious for raising ones tolerance so I gave myself a tolerance break, taking no benzodiazepines for a week to see if I could re-capture the initial effect.
3rd dose - 8 days later - I took 3mgs of f-LAM which had NO EFFECT WHATSOEVER. What was really strange though was that I could continue to get good effect from the other benzos I has in my possession (my standard collection includes Diazepam and Clonazepam from the pharm end and Nifoxipam, Clonazolam, Flubromazepam and 2,Chloro - Diazepam (Diclazepam) from the NPS end). The only way I can explain this specific tolerance escalation to f-LAM is that the initial dose I took was so strong that it permanently blew whatever metabolic pathway the drug used to induce its effect. The tolerance appears permanent as I tries a final 3mg dose about 6 months later with only minor effects.
To conclude, Clonazolam appears to be a highly potent and pleasant drug, if benzos are your thing,but predictable in its effects, dose response and durartion.
Flubromazolam however is in my opinion a complete mystery and should be avoided, it has no predictable effects regardless of dose or tolerance and has absolutely no use beyond trying a single dose out of curiosity
Thanks for reading yet another long winded post. I hope that it gives THCified some idea of these drugs and their effects.