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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

The EADD 3-FPM Megathread

Oiiiiii! Yr still a Greenlighter. Hark c'mon man get posting n become oneof us hah :D

Evey

"One of us, one of us"

First thing I thought of!

-

30mg 4F-MPH insufflated today for a functional day, rather than a cracked out one.

I'm off the 3-FPM now until after Christmas. I need to drive half way across the country and back again over Christmas, and 3-FPM completely ruins my ability to drive.

Don't stim and drive

(((o(*゚▽゚*)o)))
 
Trying to focus on life outside of BL atm, but thought I'd swing by and remind you all, especially new and future users that 3-FPM is very likely to be, and shows all the hallmarks of being, neurotoxic as shit.

I joke around a lot on here, but this is a matter no one should approach uninformed.

DRA's are literally brain destroying compounds when abused, there's no two ways about it. Typically the damage results from the sheer amount of DA floating around (DA fits SERT like a spiked glove: it goes in but tears the Hell outta' the receptor as it does so) and the most famous example of this is from Methamphetamine abuse. Meth increases striatal DA conc. by an absurd factor and is well documented, 3-FA never reached the market because it is not much weaker than MA in such a function (it also showed major cardiotox. worries), 3-FPM presents a similar potential for striatal destruction along with pulmonary hypertension/valve hypertrophy.
The widely reported balance issues when binging likely come from Dopaminergic destruction in the same vein as the loss of fine motor control in Parkinsonian disorders.
Now add in the amnesia complaints.
The irrationality when stopping.
The sleep disturbances.
The shakes.
The sweats.
The cognitive disruption.
The paranoia.
The destruction of thought clarity.
The mood affectivity.


Yes, 3-FPM is great fun, but there is no way on Earth it isn't tearing your brain a hole as it does so.
Scaremongering ain't my style, but I'd rank 3-FPM in the same league as Methamphetamine in its potential for neuronal destruction.

Have fun, but don't think for a second it's as gentle as it feels.
 
Sprout just because you no longer do stims no need to try scaring us off it. Why did you make this thread n why come out with this now? If I'm going to die then it's mean to be there's risks with all substances n situations. Not trying to be funny but it irks me when someone decides to stop doing substance(s) they try putting others off it too yet never mentioned this before.

Evey
 
Trying to focus on life outside of BL atm, but thought I'd swing by and remind you all, especially new and future users that 3-FPM is very likely to be, and shows all the hallmarks of being, neurotoxic as shit.

I joke around a lot on here, but this is a matter no one should approach uninformed.

DRA's are literally brain destroying compounds when abused, there's no two ways about it. Typically the damage results from the sheer amount of DA floating around (DA fits SERT like a spiked glove: it goes in but tears the Hell outta' the receptor as it does so) and the most famous example of this is from Methamphetamine abuse. Meth increases striatal DA conc. by an absurd factor and is well documented, 3-FA never reached the market because it is not much weaker than MA in such a function (it also showed major cardiotox. worries), 3-FPM presents a similar potential for striatal destruction along with pulmonary hypertension/valve hypertrophy.
The widely reported balance issues when binging likely come from Dopaminergic destruction in the same vein as the loss of fine motor control in Parkinsonian disorders.
Now add in the amnesia complaints.
The irrationality when stopping.
The sleep disturbances.
The shakes.
The sweats.
The cognitive disruption.
The paranoia.
The destruction of thought clarity.
The mood affectivity.


Yes, 3-FPM is great fun, but there is no way on Earth it isn't tearing your brain a hole as it does so.
Scaremongering ain't my style, but I'd rank 3-FPM in the same league as Methamphetamine in its potential for neuronal destruction.

Have fun, but don't think for a second it's as gentle as it feels.

Hell man, which fun drugs aren't neurotoxic? How neurotoxic is the ol' booze? How neurotoxic is life itself? Totally get what you're saying and it's a fair warning, but neurotoxicity covers a very wide scale - there's N2O neurotoxicity, then there's MPTP neurotoxicity ...
 
Its an unresearched chemical, things come to light over time with more use. If you dont want to take the advice then fine but dismissing a very well researched and constructive post is both pretty stupid and also rude.
 
I've mentioned it numerous times if you take 5 minutes to even search my screen name alongside the drug name.
Do not rely on me for your own education on what you put into your own body.

I don't know if you've noticed either but 3-FPM is completely novel and almost completely unresearched. I am not a psychopharmacologist, I am not an expert by any means, I am far from resembling any kind of academic authority, I'm a Junkie with a slight knowledge of Biochem. trying to provide information that doesn't fucking exist yet!

Fuck it, I'm out.
 
How do you know it's fully researched? I just it frustration that people appear to glorify stuff n when they give it they tell us all the reasons why shouldn't tale it. It would have neen nice to be told of this before I started using that's all I've given my thoughts on this. Really annoyed now so best i stay out this thread a bit.

Evey
 
How do you know it's fully researched? I just it frustration that people appear to glorify stuff n when they give it they tell us all the reasons why shouldn't tale it. It would have neen nice to be told of this before I started using that's all I've given my thoughts on this. Really annoyed now so best i stay out this thread a bit.

Evey

Your posts are becoming more Polish by the mg :D
 
How do you know it's fully researched? I just it frustration that people appear to glorify stuff n when they give it they tell us all the reasons why shouldn't tale it. It would have neen nice to be told of this before I started using that's all I've given my thoughts on this. Really annoyed now so best i stay out this thread a bit.

Evey

You really have no idea of what the term RC means, do you?
I've been espousing my worries before, during and after my use and if you'd taken 5 minutes to do any research on this site alone you would have seen that.
Get annoyed all you like, just realise the guy providing you with HR information is probably the wrong guy to get annoyed at.
 
Here's an potentially relevant paper on dopamine releasing agents and neurotoxicity. No TL;DR because a) I'm only halfway through reading it at the time of linking, and b) if you can't take the time to read 20 pages you frankly have no business screwing with this shit in the first place. It's primarily about meth, but as best I understand it (and Sprout knows his shit better in this area than I do, so please correct me if I'm spouting bollocks) the mechanisms involved should be general for any dopaminergic stimulant, including 3-FPM. However, that is speculation, and without proper study we have no way of confirming the actual effects of 3-FPM in the brain, so you are still playing with fire, taking this shit. Hopefully the info here is helpful in reducing the risks we are taking, though.
 
Your posts are becoming more Polish by the mg :D

How do you know it's fully researched? I just it frustration that people appear to glorify stuff n when they give it they tell us all the reasons why shouldn't tale it. It would have neen nice to be told of this before I started using that's all I've given my thoughts on this. Really annoyed now so best i stay out this thread a bit.

Evey

Evey, although what Sprout is saying 'could' be true, no one knows for sure because 3fpm is a totally new and unresearched chemical. These new drugs are called 'Research Chemicals' because it is us who are doing the research. But just to balance things a little, this whole website was founded upon a highly neurotoxic and largely unresearched chemical - MDMA. There have been some casualties along the way for sure, but considering the number of people who have hammered the arse out of it for years, the safety record is pretty good. Then there's mephedrone - that was also totally unresearched and extremely popular, and very few casualties have come to light (yet). I'm not saying 3fpm is without risk, but things need to be looked at with perspective
 
The MDMA reference actually perfectly supports the point I'm making, just in a slightly different manner - the original worries about MDxx destroying the Substantia Nigra spawned from a very simple error: the study that started 20 years of worry came about when the research team received Methamphetamine instead of 3,4-MDMA, and the quantitative results showed complete neuronal annihilation - the error was only realised when no other team could recreate such terrifying results.

MDMA thus presented less of a concern than initially thought, which is and was a massive relief, but MA is terrifyingly destructive and was proven to be by the same result.

That MDO bridge shifts the tables entirely, rendering MDMA a TRA with highly preferential release of SE. MA is an incredible DRA primarily, but also releases SE and NE in a much reduced capacity. DA is the NT that presents the greatest neurotoxic capabilities - not only does it ruin one's SERT system in excess, it regulates an inordinate amount of functions we take for granted. The final kicker is that DA metabolism by MOA-b can result in the formation of free radicals (arguably the last molecules on Earth you want flooding your squishy matter) - these radicals are typically mediated by... sleep. Insomnia after an MA/3-FPM binge is both expected and the last thing your brain needs.
That is why DRA's ruin you cognitively.

And that's if 3-FPM is a pure DRA as per the literature, it can only get worse if such a potent DRA (EC50 ratios) exhibits extra functions.
 
Hey Sprout, do you have a link for more information on dopamine damage to the serotonin system? I'm reading into this stuff now, because I would really rather not gack my serotonin system more than the SSRIs are already, and you know what you're talking about more than me.

Link above is primarily about oxidative stress from methamphetamine, as well as which dopamine subreceptors are involved in producing neurotoxic effects. I would be interested to learn more about what the subjective effects of the dopamine subreceptor inhibitors mentioned in that paper are when taken in conjunction with DRA stimulants, but that's likely something that is hard to get funding for. Maybe something worth trying, assuming the receptor inhibitor is not damaging in its own right of course.

I think I will definitely be avoiding pulling any sort of binge again with this stuff, and taking what I can to reduce the damage caused when I do take it again, and not doing it very often. That's all a good idea anyway of course.
 
The MDMA reference actually perfectly supports the point I'm making, just in a slightly different manner - the original worries about MDxx destroying the Substantia Nigra spawned from a very simple error: the study that started 20 years of worry came about when the research team received Methamphetamine instead of 3,4-MDMA, and the quantitative results showed complete neuronal annihilation - the error was only realised when no other team could recreate such terrifying results.

MDMA thus presented less of a concern than initially thought, which is and was a massive relief, but MA is terrifyingly destructive and was proven to be by the same result.

That MDO bridge shifts the tables entirely, rendering MDMA a TRA with highly preferential release of SE. MA is an incredible DRA primarily, but also releases SE and NE in a much reduced capacity. DA is the NT that presents the greatest neurotoxic capabilities - not only does it ruin one's SERT system in excess, it regulates an inordinate amount of functions we take for granted. The final kicker is that DA metabolism by MOA-b can result in the formation of free radicals (arguably the last molecules on Earth you want flooding your squishy matter) - these radicals are typically mediated by... sleep. Insomnia after an MA/3-FPM binge is both expected and the last thing your brain needs.
That is why DRA's ruin you cognitively.

And that's if 3-FPM is a pure DRA as per the literature, it can only get worse if such a potent DRA (EC50 ratios) exhibits extra functions.

Good post Sprout, and I must admit I'd forgotten about that fuck up with the MDMA research. I've often wondered (but never bothered to research) if Parkinson's disease can be caused purely by the abuse of dopaminergic drugs. It would seem logical that there is a causal link between the two, but its something I've never heard about.
 
Did anybody see that show a few years ago where the young guy (I think he was 30) had Parkinsons? On some days L-DOPA was giving him very little relief from his symptoms. They gave him a dose of MDMA and he was almost completely freed up. He was running around doing cartwheels! Obviously not a sustainable treatment for Parkinsons..

EDIT: I found the show but it's dubbed in German: https://www.youtube.com/watch?v=-v1QxzyCSi4. He's also, actually, 39. He takes the MDMA and does gymnastics at around 12:30 in the video.
 
I hate being able to agree to the comments regarding the neurotoxicity of 3-FPM, as I obviously have developed an acute addiction to it.

I've seriously abused it, and I have experienced, and still have issues with inflammation and especially poor blood flow to my feet and hands.

I'm highly more likely to encounter bad effects from it as I'm naturally very slim and have virtually no fat stores anywhere on me. I weighed just under 10 stone before starting the use of 3-FPM, and now I'm under 9 stone. Muscle atrophy has occurred quite considerably, and I'm just a walking skeleton with skin around it.

Not to mention the constantly elevated heart beat and general uncomfortable feelings with my heart.

It's obvious I should see a doctor pretty quickly, but 3-FPM seems to change the way you think and act quite considerably.

It's a pretty scary substance with soul destroying properties. You can't realise this until you stop using it.

It reminds me of Spider-Man 3 and the black symbiotic thing that literally changes who you are.
 
Loving all the people on here defending 3-FPM to the grave...Well I say all, some. Evey has done her usual and basically fucked off because someone has said something that doesn't agree with her method of thinking...ho hum. But seriously though, Sprout speaks some serious sense here. The huge DA release coupled with the addictive nature of 3-FPM is a serious worry! I mean, there was a poster on here a few weeks back who had smashed 7 grams in a weekend!

I don't often wish for a compound to be banned, but this shit sounds nasty.
 
For sure this one sounded just too fiendish to try to me. Plus the fact it's only good via one ROA and the short duration:addiction potential put me off anyway.
 
If you hate it, take a guess as to what experience I have to try and inform others... ;)
It's no consolation at all, I know, and that winking emoticon says more than words can.
3-FPM is, in the sickest sense, perfect: just enough pleasure to go until your body gives out, DA selective enough to ruin your self-control and yet keep you binging, anorectic enough to remove the thought of food from disturbing your binge, enough NE release to just about keep you going without overwhelming you, neurotoxic enough that you don't realise how fucked you are until you quit, natural feeling enough to convince you it's not happening to you as you read my words...

Evey, you wonder why I've brought it up now - take a fucking guess... hint: so the rest of you don't end up like the poster child I became.
The rest of you: wake the fuck up. I deluded myself in the same way.
 
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