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Nootropics The Big & Dandy Nootropics Thread (Stack 2)

Please don't post on brands, we really can't use apparent promotions or advertisements. It also borders too much on other grey areas.

Just post the ingredients of a stack instead, for the post I moderated that would be:

vitamin B, D, L-tyrosine, phosphatidylserine, taurine, bacopa, gaba, ALA, vinpocetine, sulbutiamine, huperzine A

In response to that: I think that

- ALA is a decent anti-oxidant
- cant comment on vinpocetine, sulbutiamine and huperzine A (although I'd be careful with cholinesterase inhibitors),
- GABA hardly has any effect, you have to take quite a bit and then get a very transient effect of prickly flushed face and gentle relaxation before its broken down super quickly
- Bacopa has a good reputation as brain tonic but it gave me brain fog about twice as much as it gave me a weird sort of clarity.
- phosphatidylserine on its own I actually liked!! gave me a feeling of being well, not euphoria but just good functioning
- dont have much faith in tyrosine, also gives me headache
 
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So, I've been suffering from anxiety, depression and fatigue for the past 2-3 years. It's the first time I've been through anything like this and I'm 29. I have a feeling that I have some kind of physical imbalance, rather than any specific concerns. I'm definitely not one for worrying. The feelings of anxiety are purely a physical sensation.

Since last Friday (4th Dec 2015), so the past eight days, I've been taking a nootropic stack which has completely 100% reversed my problems and given me a ridiculous amount of energy and focus. I'll elaborate on which nootropic I think is doing what.

1500mg Aniracetam: (Eliminates anxiety, improves focus)
250mg CDP-Choline: (Counteracts acetylcholine depletion)
500mg Ashwaghanda: (Eliminates depression, anxiety)
1500mg Rhodiola Rosea: (Eliminates fatigue)
1 capsule Ginkgo Biloba: (Probably just enhances the stack in general)

I can not begin to express what a godsend this has been. For about five hours after dosing each morning I feel like an absolute machine. A happy one, who does things, and enjoys them. I've never felt so energised and alert. After that I just feel like a normal person, and relatively happy/free from anxiety.

However, since taking it my sex drive has been massively reduced. I believe this to be the Rhodiola Rosea, and there is a thread or two on longecity with people talking about similar experiences.

I really want to keep taking it, but if I'm concerned about causing any permanent damage to my sex drive. Short term term I can deal with. Long term I can't. I like it high.

Does anybody know anything about this/have experience with it? Can anybody speculate as to what is going on on a neurological/physical level? I've heard Rhodiola Rosea is a mild MAOI.

Any input massively appreciated.
 
I've no personal experience with it. But from what I've read--and like you said--it seems to work at least partially through MAO-A inhibition.

Depending on whether it's a substrate or a suicidal ligand, this could help to explain the reports of "permanent" sexual dysfunction because MAO can take weeks to months to return to baseline levels. Also, obviously, there are many people who report long -lasting sexual dysfunction even after discontinuing SSRIs--you have to keep in mind that anything with an antidepressant/calmative function tends to depress sex drive: SSRIs do, opiates do, 5ht1a agonists do, barbiturates and benzos do--long term at least--alcohol doesn't really, though it obviously interferes with erections--and it's mechanism of action is really complex.

Personally, I wouldn't worry too much about it... But given that there are reports out there of this, and that you're experiencing this side effect, it seems reasonable to discontinue use and switch to another calmative. That's where you have to calculate for yourself how much it's worth to you and to what extent you might be able to achieve similar effects with something else.

For example I noticed you didn't mention L Theanine. It's often overlooked but I actually find it quite remarkably powerful as a mood stabilizer--it's obviously no benzo--maybe more comparable to buspirone or lithium--but it really smoothes out the edges in life--in fact too much can leave you with a flattened affect.

Also fasoracetam is an AMPA modulator that's accused (quite obviously incorrectly) of being a GABA antagonist--it caused long term up regulation of GABA receptors (likely through a downstream effect of its activity elsewhere in the glutamatergic system), yet without inducing short term anxiety. For this reason it's been used as a tool by a number of people to reduce ther tolerance to benzodiazepines or phenibut. It may not be for you--but I think more people with anxiety problems should give this a try, since it represents a much more sustainable approach to treating anxiety than agonist therapy.

Otherwise, you should obviously be aware that there are plenty of ways to stoke your libido, if you just want to treat the side effect, or restore it to normal if turns out to be somethig that doesn't end when you stop taking your supplement:

First of all. Exercise. Exercise exercise exercise. In particular, strength training over cardiovascular training. Building muscle boosts testosterone and causes all kinds of changes in your neuro endocrinology.

And then there's all the obvious supplements people talk about like maca, horny goats weed, tribulus etc... But also zinc and vitamin d supplementation are important. And anything that boosts LH/FSH or testosterone and estradiol: toremifene is a selective estrogen receptor modulator used by steroid users after a cycle of androgens to restore their natural testosterone production (it does so by competing with estradiol, but only mimicking it's functions at some receptor sites). Sex hormones play a huge role in libido. This may seem extreme to you but it's commonly available on a number of nootropic sites off the top of my head, and I would only suggest it as a way to possibly restart your libido should it fail to return.

There are also peptides like melanotan II and bremelanotide that are known to be potent sexual inducers. And many drugs like 5-meo-mipt and 2c-b can really significantly increase sexual pleasure.

All this being said, I doubt you have anything to worry about. Most things you do to your brain, whether you want them to be or not, aren't permanent. You'll likely get your libido back. Even if not right away, it would come back with time.
 
^Thanks for the extensive and detailed reply; it's exactly what I was after. My sex drive has mostly returned, but the nootropic stack also appears to have lost its potency. I just think about sex less, and random/morning erections have become fairly absent. Everything still works perfectly, it's just as if I have to want to do it. It would only bother me if I cause some kind of permanent damage. I'll just have to keep an eye on things. This is the longecity thread. I'd take the sudden end of activity in the thread by the affected posters as an indication of their libido eventually returning. Certainly something to be aware of, though.

Is fasoracetam an "acetam" style piracetam family drug, or something completely different? Only a few days ago I was searching on ways to reduce benzo tolerance, so this interests me greatly. I love the odd benzo, and I don't have a benzo habit, but I do have a fairly ridiculous tolerance to them. My benzo tolerance has roughly doubled from baseline, and I need 4 mg aplrazolam or 40mg diazepam to have any kind of effect. Any consequent dose will roughly double, and it makes a strip of benzos a fairly expensive and fruitless investment, with lots of added amnesia. I'll probably get some, and L-Theanine too, thanks.

Has anybody got experience with using nootropics for fatigue? I'm going to order some ginseng, as it's the fatigue which is really causing my anxiety and depression. Last week I had loads of energy, but somehow my stack has seemingly become suddenly ineffective. I'm going to add some ginseng, as I've heard good reports.
 
Just curious if anyone has ever tried garcinian camboga for energy cand fatigue? I know its not a nootropic but I find it very useful for energy but without adding anxiety. It's for weight loss but I love it for working out or just a lil pickme up.

It reminds me of dmaa which I absolutely loved.

Also about to try matcha. Supposedly contains theanine but is better than straight green tea. Anyone have any experience with matcha?
 
I just ordered some Phenylpiractam (caphedron) and I'd like to know more about it's positive effects, possible negative side effects and interactions.

Does it have negative interactions with Lexapro (an SSRI)??

I'm hoping not cause I take that daily and realize I should have checked ahead of time, but I already placed my order.

What about Klonopin?

Does it have it negative interactions with that?

What are it's positive effects and how often should one take it and how long does it take to know if it's working??


I am COMPLETELY new to the world of nootropics and have never tried them before and only read a little of this thread so I'm really a noob in this area and could use some advice/info on what to expect and how to use this properly.

I'm not actually looking to get anything specific out of it, I'm just a curious drug user who likes to experiment but also tries to stay relatively safe and not fuck up my body.

Any advice would be appreciated.

Thanks
 
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Is it dangerous to combine low doses of Tianeptine with low doses of Klonopin? I am on 1mg Klonopin per day and I do have a benzo tolerance, but not much of an opiate tolerance. As I've heard, tianeptine has mild opioid effects at larger doses, but I was planning on starting slow regardless.

I heard that 12.5mg Tianeptine 3x daily is enough for the antidepressent effects. I'm thinking about starting slow and working my way up, but I read that to achieve a 'high' or buzz off of it you need to consume 100mg+ or so. Again, due to the possible CNS respiratory depression interactions, I'll start as slow as possible. Excited to try this one, though. It might make a decent replacement for kratom as kratom is no longer legal in my state.
 
I just ordered some Phenylpiractam (caphedron) and I'd like to know more about it's positive effects, possible negative side effects and interactions.

Does it have negative interactions with Lexapro (an SSRI)??

I'm hoping not cause I take that daily and realize I should have checked ahead of time, but I already placed my order.

What about Klonopin?

Does it have it negative interactions with that?

What are it's positive effects and how often should one take it and how long does it take to know if it's working??


I am COMPLETELY new to the world of nootropics and have never tried them before and only read a little of this thread so I'm really a noob in this area and could use some advice/info on what to expect and how to use this properly.

I'm not actually looking to get anything specific out of it, I'm just a curious drug user who likes to experiment but also tries to stay relatively safe and not fuck up my body.

Any advice would be appreciated.

Thanks

I do not believe phenylpiracetam affects the same systems as SSRIs or benzos so it should be safe to combine.
 
I do not believe phenylpiracetam affects the same systems as SSRIs or benzos so it should be safe to combine.

Thanks, I have a couple more questions though:

Sekio said that Wikipedia says that "phenylpiracetam reverses the depressant effects of diazepam" which is related to Klonopin.

So does that mean if I take the two together the klonopin won't work in terms of it's anxiolytic properties??

And if so, can I just not take Phenylpiracetam the days I take Klonopin and get Klonopin's effect and still get the racetam effect on the days I take that but DON'T take the Klonopin or will the racetam stay in my system on days on I DON'T take it and STILL effect the Klonopin on days I take the Klonopin??

Have you or anyone else here taken a benzo and a racetam, especitally this one, in combination and how did it go??

And in terms of taking the racetam, do i have to take it EVERY SINGLE DAY for an extended period of time to see any effects like I would with an SSRI??

That is what I've heard and if so, how long till I see effects and what kind of effects will I see???

And if I take the racetam, lets say, 4 days a week, but DON'T take it another 3 days if I take the Klonopin on those days, as it's my norm to take the Klon about 3 days a week, will that make it so i NEVER build up enough racetam in my system to feel any of it's effects??

Also, what kinds of effects do people usually get from racetams like this one???

Thanks
 
I would still appreciate some responses.

I just want to know more about this substance before I try it.
 
I think that no one is answering, because nobody knows.

Phenylpiracetam is a very "stimulating" nootropic. Doses around 200 mg peps me up like a really strong cup of coffee, but with more clarity and less jitteryness. I always combine it with coffeine though, which I always thougt synergize really well with racetams. I always take just one large dose when I need to be extra fresh, like exams and such.

I'm affraid using phenylpiracetam everyday will cause too much tolerance to the initial stimulating effects. And it will just be more like "regular" piracetam.

Phenylpiracetam is a bit different than other racetams though, that normally don't work at first dose. I've tried aniracetam a couple of days in a row, and on the third day I felt it. Hard to explain, but it was stimulating and a bit trippy almost. Combining it with coffee actually made me very irritable and jittery, so I stopped taking it since coffee has first priority.

Another thing to understand with the racetams, is that everybody responds very differently.

About mixing it with clonazepam: It's a well known fact, I think, that racetams reverse the effects of benzodiazepines. Or rather, they reverse the amnestic effects at least. Wether they will also diminish the anxiolytic effects, I don't know. But it could very well be like "pissing against the wind". If you get what I mean.

In my opinion, there can't come any harm of the combo, it should be safe enough. So I'd say go ahead and do the experiment. And be sure to come back and report your findings.
 
Tianeptine is a known respiratory stimulant--if administered alongside morphine it reduces respiratory depressant response at equal levels of analgesia.

So physiologically--at least in terms of any fears of sudden and total circular failure--you've got nothing to worry about.

I wouldn't really say that racetams "erase" the effects of benzos, either. They dull them, or some aspects of them, for sure.They help lift that "brain fog". But you can still feel quite benzoed while on high doses of sunifiram noopept, coluracetam, fasoracetam, phenylpiracetam, etc. Believe me, I've done it.

Btw: People like to give phenylpiracetam some sort of "special status" as a unique drug product.... and I'm not saying this is a totally wrong sentiment because it does seem to have slightly different set of effects and possibly does them in a novel way.... but keep in mind that it's basically just piracetam with a phenyl ring attached. The phenyl ring should ensure that the nootropically-active piracetam component gets to the brain. Meanwhile, the drug's "stimulation" is probably not different from that offered by any of the dozens... no hundreds.... maybe even thousands?... of dopamine and norepinephrine reuptake inhibitors and releasers which exist today.

Long story short, I *like* phenylpiracetam. But I'm not convinced that it does anything significantly different from the common stack of a stimulant and a nootropic already seen.
 
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^^^^

Thanks for answering guys.

So it SOUNDS like maybe the Phenylpiracetam MIGHT only effect the NEGATIVE aspects of Klonopin which should be a good thing.

So now I'll just ask a couple simpler questions that might be easier to answer:

1) How often would you recommend I take Phenylpiracetam to get the best Stimulating and most noticeable effects out of it??

Every other day?

4 days a week, etc??

I want to KNOW I am taking it and be able to get some effect out of it.

2) How long does it stay in your system AFTER your last dose??

If i take it 4 days a week am I likely to feel it on days I don't??


3) Would you guys recommend I DON'T take it on days I take Klonopin at least at first or would you jump straight to combining the two??

4) I drink a SHIT ton of coffee, so will I be over stimulated in an UNSAFE way if I take this drug while drinking a lot of coffee?

5) Is it safe to combine with Dexadrine??? That might be dangerous right?

6) Is it safe to combine with Kratom?

7) Is it safe to combine with alcohol?


Sorry, that's a lot of questions lol, but they MIGHT be simpler than the ones I asked before.

I am COMPLETELY knew to all Nootropics and i am quite interested in this class of drugs.

Thanks
 
I actually find that -racetams combined with stimulants or empathogens seems to make the whole experience smoother and more satisfying, with less comedown. I wouldn't say it increases the stimulation. I haven't tried it with phenylpiracetam, but I have with piracetam and oxiracetam, and sunifiram.
 
^^^^


1) How often would you recommend I take Phenylpiracetam to get the best Stimulating and most noticeable effects out of it??

Every other day?

4 days a week, etc??

I want to KNOW I am taking it and be able to get some effect out of it.

..........................

4) I drink a SHIT ton of coffee, so will I be over stimulated in an UNSAFE way if I take this drug while drinking a lot of coffee?

5) Is it safe to combine with Dexadrine??? That might be dangerous right?

6) Is it safe to combine with Kratom?

7) Is it safe to combine with alcohol?

As you can see, InterestingFACT knows more about the combination than I do.

I can't answer all of your questions, but to the first one, I'd personally say less than every second day. Mind you, I don't have any experience taking it regularly, so I don't know from personal experience. But I read from people that took it regularly that the apparent stimulation they got from just one large dose dissappeared over time due to tolerance. As I've already said, racetams particularly of all drugs, seem to effect everybody quite differently, so I think you'll have to make your own experiences with it.

Question 4, I'm sure you can drink as much coffee as you usually do, when you are on phenylpiracetam. It won't be unsafe.

Racetams are known to enhance the effects of stimulants, empatogens and psychedelics, sometimes in a nice way, but sometimes also in a too crazy and uncontrolable way - I think caution and research is well adviced, if one wants to go down that road.

Racetams are conversely known to decrease the effects of benzo's and NMDA antagonists (like MXE or ketamine). I don't know about kratom though.......
 
I never noticed a difference with opiates or kratom. As for psychedelics, one time in particular some piracetam drastically increased the effects of 2C-E leading to my most terrifying and beautiful +4 experience to date (exponentially stronger than other 18mg 2C-E experiences I've had). Yet, other times I've combined psychedelics and racetams, there was no difference that couldn't be put down to placebo.
 
Thanks everyone.

I guess no one really know how long this stuff lasts in your system though huh??

No one knows its half life??


Anyways, sounds like a safe substance and it just arrived in the mail yesterday so I'll probably try it within the next week I'm guessing.

Since I take Klonopin 3-4 days a week I'm sure I'll try the combo eventually and report my findings.

Also, one other question, should I avoid taking it with Phenibut??

I just got some of that in the mail but I NEVER use it more than once a week, so avoiding the combo is easy, but if it could be a GOOD combo I'd like to try it.

Thanks
 
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