N&PD Moderators: Skorpio | someguyontheinternet
N-fluoroethyl at the terminal end should be okay.
Indovalerone ..
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does that exist?? cathinones Cross tryptamines
Yes, it can exist. And while I realize that mixing and matching various functional groups from among wildly disparate drug classes is not usually a recipe for success, in this case I bet your "indovalerone" is active, just not in a good way due to similarity with 5-MeO-AMT. Switch the 5-MeO for a 5-H or 4-OH, and I think you will be in business.
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But I agree with Solipsis that these, too, may be all out nightmares on Elm Street like Shulgin's pyr-T's reportedly are.
As for the LSD variants, I don't think LSD is going to be beaten in terms of potency or profundity of the psychedelic experience, but nevertheless, I won't let that stop me from proposing one:
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whose theoretical ideation was inspired by the purported endogenous cannabinoid ligand in mammals, anandamide.
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ANANDAMIDE
Adding a 1-pentyl group might be a nifty addition as well:
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I was actually thinking about this here on this:Yes, it can exist. And while I realize that mixing and matching various functional groups from among wildly disparate drug classes is not usually a recipe for success, in this case I bet your "indovalerone" is active, just not in a good way due to similarity with 5-MeO-AMT. Switch the 5-MeO for a 5-H or 4-OH, and I think you will be in business.
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I was actually thinking about this here on this:
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the MD doesn't really do anything except may be altering PK. So why not put an indole. But then again, you end up with a bkDMT skeleton like this among others:
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Which is why I thought it could be a mdpv-dmt cross. Or bk-AMT (kind of!) if you substituted on alfa. Now, since for some reasons I have always been fascinated by a "5-methoxy" on indoles so I put in on. But you're right, without the 5-methoxy, it would probably behave more like mdpv
lorcanserin
wiki said:Vabicaserin (SCA-136) was a novel antipsychotic and anorectic under development by Wyeth. As of 2010 it is no longer in clinical trials for the treatment of psychosis. It was also under investigation as an antidepressant but this indication appears to have been dropped as well.
Vabicaserin acts as a selective 5-HT2C receptor full agonist (Ki = 3 nM; EC50 = 8 nM; IA = 100% (relative to 5-HT)) and 5-HT2B receptor antagonist (IC50 = 29 nM). It is also a very weak antagonist at the 5-HT2A receptor (IC50 = 1,650 nM), though this action is not clinically significant. By activating 5-HT2C receptors, vabicaserin inhibits dopamine release in the mesolimbic pathway, likely underlying its efficacy in alleviating positive symptoms of schizophrenia, and increases acetylcholine and glutamate levels in the prefrontal cortex, suggesting benefits against cognitive symptoms as well.
I do think cathinones are similarly unstable, khat appears to be of decent quality only for up to about 48 hours apparently...
The dimerization is not the only issue, oxidation may be as well.
Not sure but one would probably be getting oxidized to fully aromatic pyrazines driven by aromaticity energy gain. But hard to tell really..Plus I wonder about alternative degradation routes from the dihydropyrazines?
And synthesis / storage issues aren't even considered... although apparently it was surmountable for bk-2C-B.
But even secondary amines appear to be able to react with ketones to yield enamines and we don't seem to have much trouble with that happening with our N-methylamine drugs... so could be much ado about nothing.
@dotchem: Is that lorcanserin? They don't really look similar enough IMO..