Nifoxipam sensitivity to heat? Solubility?

[Solipsis]

I said isopropanol might be an option, that's hardly a promise. Ethanol should be decent, as was roughly calculated, but with that you may approach solubility limits. Isopropanol is a little less polar though. And 30 ml is very little - probably too little on its own even if it was ethanol, it was mentioned already that about 50-100 ml ethanol should do it. That should have meant something.

Using a little DMSO for initial dissolution before proceeding with isopropanol may help avoid these problems, in fact it may be your only play here if you want to avoid just wasting your isopropanol. Is it correct that you don't actually have the DMSO, and you say you are broke? Better hope that the PG helps here instead of disrupting proper dissolution.

At the risk of sounding more and more like a dick here... I appreciate that your benzo habits cost quite a fortune, but if it causes you not to have enough money left to be able to safely handle or prepare the potent benzo powder you afforded, it doesn't seem fair to take it out on anyone but yourself. Although granted, the PG not working was probably unexpected enough..

Just curious: do you have a very accurate scale?

 

[AlphaOdure]

I said isopropanol might be an option, that's hardly a promise. Ethanol should be decent, as was roughly calculated, but with that you may approach solubility limits. Isopropanol is a little less polar though. And 30 ml is very little - probably too little on its own even if it was ethanol, it was mentioned already that about 50-100 ml ethanol should do it. That should have meant something.

Using a little DMSO for initial dissolution before proceeding with isopropanol may help avoid these problems, in fact it may be your only play here if you want to avoid just wasting your isopropanol. Is it correct that you don't actually have the DMSO, and you say you are broke? Better hope that the PG helps here instead of disrupting proper dissolution.

At the risk of sounding more and more like a dick here... I appreciate that your benzo habits cost quite a fortune, but if it causes you not to have enough money left to be able to safely handle or prepare the potent benzo powder you afforded, it doesn't seem fair to take it out on anyone but yourself. Although granted, the PG not working was probably unexpected enough..

Just curious: do you have a very accurate scale?

Solipsis ya don't sound like a dick at all, but rather a very HR-orientated, concerned mod and i do blame myself here. Just asking for help in correcting the issue. I honestly probably should've just done a quick google search on nifoxipam & solubility before assuming it was just another run of the mill benzo.

Yes i have a 0.00xmg scale

Only had enough money for the 30 ml of iso.. which will be here probably friday

and no don't have the DMSO.

hmmmmm.. what to do... ? Hopefully by the end of the week though i will have $50 a friend owes me for some mexedrone he's been wanting to try that I am waiting on from my drug dealer.. i mean.. mailman

 

[AlphaOdure]

At the risk of sounding more and more like a dick here... I appreciate that your benzo habits cost quite a fortune, but if it causes you not to have enough money left to be able to safely handle or prepare the potent benzo powder you afforded, it doesn't seem fair to take it out on anyone but yourself. Although granted, the PG not working was probably unexpected enough..

Yes but at the same time, I ordered the nifoxipam w/o knowing all of this extra work/cost/investment would be necessary.

And my benzo habit has only been going on for about a month or so, but honestly, i don't even get high (well i'd be a liar if i'd say once in a while i don't take an extra few mL's of clonazolam for a nice relaxing evening or to calm me for an especially stressful situation; but i also have gabapentin for that now too.. which actually works great stacking-wise via plugging, off topic real quick, but: i think the l-amine transporters (if i got that right) that get "saturated" w/ GBP are different/separate- one for the gut, a different one for the intestine- see my post here. so you're able to get to your desired GBP level more quickly.. i would dose orally & rectally concurrently- used same dose on day 3- which was 10x 300mg, & i got just as ripped as i did on the first day. Completely impossible if i woulda stacked orally; oh.. and i did shove a naproxen up my bum too lmao didn't know if that would help w/ absorption in the intestine or not? but worth a shot)

ANYWAY Its more of an antidepressant than anything else? I'm not laying in bed till 4pm watching TV (or chasing women & revolving my life around a fuck buddy or g/f) anymore.. no.. i'm on here.. i'm outside.. i exercise... used to have horrible anhedonia & no interest in any of my hobbies like guitar/writing music.. thats now changed. used to have problems w/ EXTREME anxiety & leaving my house.. which i don't anymore. I would feel disorientated & sick & even dissociated in a way when trying to converse w/ someone in public. So i'd also avoid any public venue, as it would make me so uncomfortable. & this obviously stopped me from pursuing a job (now i'm placing apps daily! hopefully clonazolam wont show up! lol, heard it hasn't--not trying to talk DT'ing here though). Now this has all changed. I'm up in the morning, converse w/ my g'ma (used to only say a word or two to her & have some unwarranted resentment w/ her). And i only dose my BZP's at night... none in the morning. Its a strict regimen. And my doses haven't increased.

I did mention i was dosing somewhere around 25-35mg of clonazolam (of "questionable" quality) & was going to order from another vendor to compare. But, instead, i ended up ordering flubromazolam as it was cheaper & i've used it before w/ similar results. So unfortunately i wouldn't be able to do a direct comparison to quality.. although, i could of course just use a benzo conversion chart. & if i end up having to need like 10-20mg of flubromazolam a couple times a night.. well, then i guess that means the last vendor wasn't cutting his stuff? OR i'd be just extremely unlucky & got a bad batch from a 2nd vendor too? wouldn't that be a crock! (or how about the more obvious answer? huuge ass tolerance, lol)

 

[AlphaOdure]

it was mentioned already that about 50-100 ml ethanol should do it. That should have meant something.

sorry i totally missed that point. its a 2-3hr drive to get everclear where i live (regressive laws around this area in regards to access to solvents/ethanol if you ask me) so you think this 30ml of iso (NOT denatured) wont dissolve the remaining nifoxipam?

Maybe it will because....
admittedly i did consume some sludge. i tried to tare my scale w/ my little metal microgram spoon, then scooped the nifoxipam sludge & weighed & dosed...knocked me out for the the night at least (guesstimated the dose)? my tolerance would prob lend me to about 10-20mg for effects from nifoxipam, i'm guessing.

so is this 30mL iso alcohol (non denatured) basically a waste? or would it work? still have coffee filter w/ nifoxipam, and then there's the 2nd bowl i did a reverse CWE that has yellowish liquid in it (has been sitting on heating pad evaporating off H20 for 2 days lol), & that original flat dish w/ the nifoxipam sludge (which is where i dipped my spoon in..but its also on this heating pad to evaporate any H20 as well)

Where should we go now?

Do you think i i have enough iso to dissolve the coffee filter containing nifoxipam...and then dissolve the original flat plate of PG+nifo sludge... & then the 2nd bowl w/ yellowish liquid.. keeps losing volume from evaporation..

just scared i'm damaging nifoxipam though!!

 

[Solipsis]

I dont expect the iso alcohol itself to dissolve all your nifoxipam. You should probably take only a portion of your nifoxipam to try and dissolve it for the reason that:
- if you fuck up you dont lose everything, but if you succeed you get a better idea of what it takes to dissolve your entire batch.
- less nifox would fit in less iso alcohol, if it does at all. I mean it should dissolve a bit, but the question is rather if you can fit enough in solution to make it reasonable

If somehow you get some nifox in a solution, so no sludge but a liquid that evenly contains the nifox, if you at least know the order of magnitude (meaning ballpark, whether its closer to 1, 10 or 100 mg) you can titrate : by starting really low and slowly working your way up doubling every few hours until you see effect. At least that it less unsafe than just eyeballing sludge.

I'd start with the coffee filter that is rather dry, because if I understand correctly it doesnt have PG on it, so that is one less of a wildcard factor.

Benzo's by themselves do cause blackouts (though the hypnotic and muscle relaxant ones probably less deleriant drunk bouts of stupidity?) but deaths not really that often. That is not supposed to serve as a comfort that you can just mess around with nifox sludges or anything like that...
Rather that it is important that you don't take other drugs with it if you are not in control of how you are dosing. And also that forking over some effort time and or money to get materials like say everclear DMSO or at least enough of the right solvent (iso prop may work if you have tested a little of it, these are about 3 options mentioned all throughout the thread with varying advantages and disadvantages), can save you very nasty and dangerous accidents that may end up costing you SOO much more in every conceivable way.

The heat may very well be damaging to your nifox, it kinda depends if it reaches scorching temperatures at parts that are getting dry or if total temperature of the sludge gets ridiculous.

The vapor pressure of PG is about 100x as low as that of water, so take a guess at how much slower it evaporates compared to water...

Under normal conditions benzos are pretty stable but it's not like nifoxipam has no reactive groups on it whatsoever either >> the heating is a bad idea IMO, if you cant do fancy extractions then at least get some solvent to try and salvage it, DMSO even. Otherwise I'd leave it alone, getting frustrated about it and doing foolish things isn't likely to do you any good. Not that we here have all the solutions to this problem (no pun intended), but desperation is not really a substitute for a scientifically sound approach.

 

[AlphaOdure]

well the DMSO really put me off w/ the garlic & sulfuric taste you said it'd have... but... in light of it possibly being the only viable
candidate here i wish i woulda gone w/ that

and i just had the 2 bowls setting on an electric heating pad you'd use for your knee or arm.. nothing scorching- so hopefully its not damaging the nifoxipam?

i am running into some money here shortly... and i may order some DMSO w/ it; just use the iso to dissolve the coffee filter. Now is leaving the nifo out at room temp w/ the light occasionally on in my basement going to be destructive to this molecule too? idk, if its something as reactive as say LSD for christ's sake lol.

 

[AlphaOdure]

well what happens if i do just add the h20/sludge solutions w/ the nifoxipam to my iso? worst that could happen is that it wouldn't dissolve and i'd have another mess on my hands eh? soo.. i guess just try the coffee filter first, see if that works in the iso? and go from there? possibly wait on DMSO? but it seems like the general opinion here is that the pg sludge+nifo & h20+nifo (not a lot left) shouldn't be dissolved in the isopropyl if i'm understanding things correctly? or should i see how things go first w' the coffee fllter?

 

[AlphaOdure]

WELL BOY I AM I FUCKING ROYALLY PISSED

My grandmother came down to get the heating pad & just "washed out" all the fucking god damn mother fucking nifoxipam bowls i had. And she knew EXACTLY what she was doing too. uggh.

so now all i have is this coffee filter... no need for the DMSO anyway. Some $60 down the drain of a novel benzo i was sooo patiently waiting to try

ugh, idk, maybe there will be enough for like half a dose on this coffee filter, that should dissolve ok in the 30l isopropyl alcohol correct? B/c was done from a reverse CWE & doesn't seem like theres much

 

[Solipsis]

Wow

'convenient'..
Perhaps she thinks that is being the opposite of enabling (disabling?) but it doesn't really work like that, ma'am, it's just a thorn in your balls.

The 30 ml iso should be about as potent as 150 ml of vodka (nearly 4 shots) as far as alcohol effects go, so careful... Seems dirty when it's only about trying a novel benzo - just saying it might color the effects significantly if you knock it down just to get a dose. But yes the alcohol should work for an itty bit of coffee filter nifox. I don't know how you figure that there will be half a dose (your dosage, not one for a person without tolerance I gather..), but start low man.

And prepare to breathe acetone.

 

[AlphaOdure]

'convenient'..
Perhaps she thinks that is being the opposite of enabling (disabling?) but it doesn't really work like that, ma'am, it's just a thorn in your balls

RIGHT! Exactly! Well she already knows i have horrible insomnia & get random packages here & there.. I just out & tell her "i take legal supplements to aid w/ my insomnia"

But, i'm already on gabapentin which sometimes makes me stagger & walk around the house like the town drunk- but i even showed her the bottle, ripped off the side effects pamphlet thingy, etc... but she still doesn't believe me. I know it. She still thinks i'm secretly getting "fucked up" all the time (which by the contents of this thread may seem true, but its really not lol, i take benzos only 2x/day at night- & at a leveled off dosage, they work almost like an AD does for me; and not ONE of the myriad of AD's i've tried from that SSRI trash to tricyclics have worked).

idk, i'm a recovering addict; her husband/my grandpa just died a month ago. so things are complicated. and i was supposed to move out w/ a g/f a week after he died & that fell apart on a dime on her accord, so i had a small bump in my recovery. And just in general her and i have never gotten along, i.e., our personality types, me & gramps always did though

BUT WHAT PISSES ME OFF...
i even remember TELLING her "there are 2 bowls of brown liquids/sludges on the counter downstairs, please do not touch them" but yet she did anyway. Fucking ridiciulous, costs me around $60. ARRRGGGG I'M SO MAD

 

[AlphaOdure]

Goddamit is she lucky i have an order of 250mg of flubromazolam coming sometime late this week/early next week or i'd be one unhappy camper! I am actully trying to get my pain management doctor to get me onto klonopin, b/c it is the only thing that works for my back & neck (via muscle relaxation)--aside from soma which you can't find anywhere anymore since its scheduling some few years ago--and she said she'd consider it (hurt my back in a severe car accident around 2006; wasn't wearing seat belt; hit ice patch & flew off the berm on the highway at 60-70mph... instead of going through the windshield & tearing off my head, my car impacted a drainage/sewer pit at a 45 degree angle & my head slammed into the top of my car.. compressed my spine big time & an earlier accident where i fractured my tailbone as as kid hasn't helped either).

She was a GREAT doctor, one of those ones who listens... answers all your questions... doesn't start to react defensively or like a parent when i start spouting out medical/pharmacological knowledge... so i hope this works out.

Side note though, do most pain doctors do regular GC/MS testing to see if you're taking your meds properly.. b/c i usually only take my GBP's when i'm in serious pain, and when i do..i stack about 10 of those suckers....

 

[belligerent drunk]

Wow, what a plot twist... I imagine how upset you are!

As Solipsis has already said, 30ml of isopropanol should do, but be careful with dosing - start low. Isopropanol is (in my experience) about 3-4 times as potent as ethanol, so the whole 30ml will be a considerable dose if you decide to drink it all at once, about equal to 2 litres of beer. Isopropanol is also, in my experience, more sedating than ethanol, so watch out for that. Definitely don't start with too high a dose since stacking depressants is dangerous.

 

[AlphaOdure]

Well,would i need the full 30mL to dissolve this negligible amount on the coffee filter even? but since its a guessing game i suppose I should use as much solvent as possible. i'm just NOT going to like consuming that much of a 99% pure alcoholic beverage..even at just a mere 30mL...

would this be pluggable? lol? or is isopropyl pretty irritable down there?

 

[AlphaOdure]

ok, i got just got the 30mL of iso... should i just pour say 15mL thru the filter into a flat pan or see through cup to test solubility?

any ideas? I'd order the DMSO asap, but i'm waiting on funds from certain *transactions* the other party in this matter seem to be delaying on...uggh...

 

[AlphaOdure]

well i'm just giong to pour 15ml of the iso into measuring cup... see how that goes... if i get a transient solution or not. If not? i can easily evaporate off the isopropyl as it is very volatile correct? then just start from square 1? Go back to some DMSO? i really hope this works b/c it doesn't seem much nifoxipam is on this coffee filter. uggh

 

[AlphaOdure]

Well after only about 15 minutes i'm getting fairly clear solution w/ 15mL of isopropyl.. no powder or anything... good sign? should i add the rest of he iso to filter & squeeze out any remaining nifo in the the solution? let it soak? or am i getting a head of myself here???

should a bit of heat be added or something? (i know w/ alcohol thats dangerous proposition & shouldn't be taken lightly)- could use some responses & suggestions ASAP peeps!

(& yes, i plan on having no other drugs in my system at the time of dosing side from my daily buprenorphine, but that would've been dosed ~12 hours ago as i take it in the morning & planning on taking this nifo solution at night before bed)

 

[AlphaOdure]

UPDATE: just before adding in the additional & final 15mL of iso, the solution was completely clear. So i poured the remaining iso thru the filter... squeezed the filter & am now letting the filter just sit at the bottom of the glass to obtain maximum absorption..

Question... Can i add water? or OJ? to make this stuff go down easer? imagine so? Or what bout plugging? Or Is plugging ethanols a pretty painful i take it? lol

Anyway, after final "rinse" w/ the coffee filter in the 30mL of iso it did take on a hint of yellowish color, but not solids. (& PG would do this too anyway depending on the color of original material, & the nifoxipam was a strong yellow).. so i think i got a winner here? I poured back from the clear glass into the original, dark 30mL isopropyl alcohol bottle to keep the solution away from any additional light sources, so i could continue shaking, & have it more portable...!

Anyone have any further input or recommendations guys?

& thank you for being sooo accommodating during this whole experience! Next time if i order a larger batch of nifoxipam i'll definitely have $$ aside for some DMSO! It is just the "sulfuric & garlic" taste that turned me off Solipsis.. lol.. & to me in my naivety it seemed as if you were saying iso was just an adequate of a replacement? But now i'll know to turn to the DMSO & just put up w/ the shitty taste!

Cheers!

 

[belligerent drunk]

If the solution is clear, not "milky", then yes it has dissolved and sounds like it had no problems dissolving. Isopropanol is not very volatile, less so than ethanol, but still better than water. I imagine plugging isopropanol would be fairly painful even if diluted and could do some damage to your colon, so I would advise against it. I imagine you have quite a small amount of nifox in your solution, so it's probably far from saturation - you can try adding water. There is a chance it won't precipitate. For drinking, orange juice is perfect, I could barely taste the isopropanol when mixed with OJ. So you can do just that, add about twice the volume of OJ and drink it, shouldn't be too bad. Even if some nifox precipitates, you can swallow the suspension; wash the cup with more OJ to get the solids in. Solipsis, correct me if I'm wrong in thinking that ingesting solid benzos should work.

Another thing though, you probably have no idea how much nifoxipam you actually have in the solution now. Do you have a scale? Ideally, you'd want to evaporate the isopropanol, weigh the the remaining powder and dissolve it again, but you're out of isopropanol. Personally, I'd still measure the mass and just try to swallow the solids by suspending it in water or something. I have never done that though, so I don't know if it works.

 

[AlphaOdure]

Well consumed the iso...i suspect the remaining nifoxipam wont even be enough to touch my tolerance (aat least 50mg clonazepam in the evening in my typical "antidepressant" dose for the next 24 hours). so i didn't evaporate it off. I did a test plug of about 1mL w/o any pain.. then another w/ 5mL..umm diff story! But i manned up & finished the full 5mL plug (ouch)...drank the rest..was a clear solution. But i still added water to the bottle afterward, sloshed it around to make sure i wasn't missing anything undissolved!

Dosed around 3:30pm..suspect i'll feel the iso way before the nifoxipam given its long onsent (60-120min onset). but we'll see w/ some added caffeine here in a bit. This was on top of 15000mg of GBP (which i'm very tolerant to); 1 300mg pill oral & 300mg pill concurrently plugged; final dose just plugged. As i've found absolute best results from this method (as i've posted in a diff thread, these two diff RAO's must saturate different LAT'S.. b/c i tired 3 days in a row dosing of GBP w/ same amounts 300mg 10x.. first day was thoroughly GABA'd up, diminished effects 2nd day as expected- but 3rd day when I dosed rectally w/ my oral dose every hour I got the same effects from my first day. So i took a smaller dose tonight as I need the extra sedation for my early day tomorrow)..also have my 4mg of subutex to dose via insufflation ins a few min here.

THEN- just relax for the rest of the evening. will report back any differing effects if felt any.

 

[AlphaOdure]

I know this isn't very "scientific" as my nifoxipam dosage is unknown.. but definitely felt heavy sedation from the isopropanol as i'm not much of a drinker (nor do i enjoy it much)- but the sedation ain't too bad w/some caffeine mixed in. Plugged one final GPA dose of 300mb at 4:30 EST. Think i'm starting to feel the nifoxipam? A bit light headed, hard to to focus- different from typical ethanol effects. Nothing major though. Plan on finishing my coffee (as it has a tendency for a bit to run out my nose since i chug it?) Then take my nightly 4mg buprenorphine dose via insufflation (goddammit the addict in me just wants to SLAM it..the whole prepping process.. watching the register as i slowly slide the rig in )

But nah, not worth it.. my veins just now healed after about a week of binging. Plus my benzo tolerance is so high from this binge period! Didn't get much more out of it, just was addicted to the whole process i suppose. Oral syringe taken sublingually does the same thing, just not as schizophrenrinically & feeding into my IV fetish! lol. Welil its been about 45 min since i've typed this up.. definitely feel more anxiolysis & heavy eyes despite coffee intake. Could have been the GBP taken rectaly 45 min ago too? or a combo w/ the nifoxipam? or the iso sedating me? But still sipping on the caffeine & about to do my final 4mg buprenorphine! see how how that goes.

Again..will report back..might not be till tomorrow though hhehe.