CBD / GABA - interactions

[thehornetjho]

Hi, i'm currently ten months into a nasty protracted benzo withdrawal (Xanax) and am thinking of experimenting with CBD for some relief of my symptoms. My question is whether anyone here knows if CBD is a GABA antagonist? As in benzo recovery we are advised to stay away from anything that could interfere with the recovery and repair of our GABA receptors, like alcohol etc. I've searched the Internet but can't find a conclusive answer.

 

[dopamimetic]

CBD can be a little anxiogenic, I suspect by it's 5-HT1a agonism which potentially lowers serotonin levels (through auto receptors), and antagonizing anandamide (the endogenous cannabinoid).. but in general it's considered to be anxiolytic and shouldn't really exacerbate GABAergic withdrawal to my knowledge. Just try it out, I guess it's a matter of dosage and if it ever should become too strong, taking one single xanax won't hurt.

Think they don't like the link here though, even if it's a legal product (and it seems a bit pricey as many CBD formulae imho).

 

[thehornetjho]

Thanks for the info... re the product (have removed the link) it's the only CBD product on the market that is water soluble which is meant to make it A LOT more effective than the oil/tincture products out there.

Guess i'll give it a try

 

[sekio]

only CBD product on the market that is water soluble

I wonder how that works. CBD is not water soluble, and if you modify the structure of it to be water soluble, then it's no longer CBD.

Maybe it's just an oil-in-water emulsion? In that case it's not "soluble" so much as a suspension of cannabinoids kept stable with Tween or whatever.

It is also worth remembering that CBD can easily turn into THC if you get careless with storage or if you smoke it. Look up th acid isomerization of CBD to THC sometime, it was an old-timey hippy trick for increasing the psychoactive potency of pot. (c.f. Doctor Atomic's Marijuana Multiplier)

 

[thehornetjho]

Here's the explanation: http://www.biocbdplus.com/water-soluble-cbd-oil

"CBD Oil that is water soluble, well, it just does not exist. CBD Hemp “Oil” is very useful and has lots of benefits, but oil and water do not mix as you already know. This is NOT easily absorbed into the body. It smells. It tastes bad. We have heard you, and we have created the solution! BioCBD™ is an all natural, water soluble source of CBD plus Ayurvedic herbs that is more bioavailable than any CBD hemp oil products on the market. Your body is composed of over 60% water, so what good is a product that cannot dissolve in water? CBD Hemp Oil products have an extremely poor bioavailability (reports show less than 10%) when compared to our water soluble BioCBD™ technology. Why pay full price when you can only utilize a small fraction of it?! With our new technology, CBD hemp oil is obsolete and water soluble is the only way to go. We are setting out to prove that our products are 5-10x more bioavailable in the body than traditional CBD hemp oil."

 

[neurotic]

"The hemp oil is then shipped to our labs, where our Chief Scientific Officer and Co-Founder, Dr. Mewa Singh, creates the all natural, water soluble BioCBD™ through a patented process known as Hybrid-Nanoengineering™."

I was looking for the ingredients or something when I ran through this in their site. Man, what a bunch of bullshit. I was actually expecting something interesting.

Sekio already pointed it out... CBD is not water soluble, it's just a property of a molecule. And I don't think that it's necessarily bad for oral bioavailability (?)

Don't waste your time with these scammers OP...

 

[dopamimetic]

Don't waste your time with these scammers OP...

and money too. CBD is so overpriced.. one could just smoke industrial hemp maybe, in my teenage years someone came with the idea to use hemp leaves as a base to apply synthetic cannabinoids on them, and the resulting stuff has been liked very much.. it was less anxiogenic than the usual stuff (I don't like smoking weed cause of that) and I'm pretty sure that was due to the CBD..

 

[belligerent drunk]

I'm pretty sure lipophilic substances would have pretty good oral bioavailability unless they're degraded before they reach the blood and exit the liver.