sekio
Bluelight Crew
When I last messed with ethylpheidate, it was one peak on GCMS.
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N&PD Moderators: Skorpio
Ethylphenidate racemic (l-isomer) to d-Ethylphenidate (d-isomer)
- Thread starter Sunbane
- Start date
When I last messed with ethylpheidate, it was one peak on GCMS. 
Interesting. I mean, they SHOULD have performed the reflux to make it all trans and were given the relevant patent. As I have said before - LAZY RC Chemists!
Remember that I pointed out that isophenidine was MILES better than any of the others i.e. it is just like K... well they can't make it! Errr... well NO, if you're thermally removing water. Simple if you use something as simple as anhydrous magnesium sulfate to remove the water. I even pointed out an example of the precise method BUT apparently changing to that was FAR TOO MUCH like hard work!
So all this time, different brands are of different potency... then again, I don't touch stims (epilepsy). I only tried that simple coke replacement 1 (my most hated stim is coke.... or that).Last edited:
dopamimetic
Bluelighter
Of course MXE isomers would be very interesting... too sad they banned it in many countries (and they will ban the IPPD as well which also is more than a pity for many ADHD people out there). I forgot a bit about it because of the cut shit they sold in the end before the final EU ban, attributed it to tolerance etc. but I was wrong. Drug tests should really be available for everyone. Recently had the chance to sample some pure MXE again and it was chemical magic once more. It's really on par with K imho, MXE is more for the low doses and K for the higher / hole ones.. And they mix quite well too.
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Shouldn't the isolated phenidates be around of double potency, so also be 'worth' +/- the double?
Just read the following:
Is it possible for IPPD to have (maybe secondary) cholinergic action? Could match some of the effects as well as the side effects, or not..?Last edited:
IPPD might become the next treatment for ADHD. The rc companies pulled it out of a research patent on better methylphenidate analogs.
dopamimetic
Bluelighter
Yeah, I've read this patent even before the availability of IPPD
just think that it'll be harder and less lucrative to get a substance approved that is known to have 'abuse' potential and gets compared to coke (it's actually better, but I didn't say that 
) ... hope they'll do it nevertheless of course. Really. I'd love to have a script for time-released IPPD in these osmotic Concerta capsules. Recently tried one of my old 18mg Concerta's again, and I hated it. It's like a caffeine overdose in comparison.
And they should combine it with emoxypine. The combo is just amazing, it literally removes every bit of hangover or rebound.
Nice find.. wouldn't this even be legal in UK etc. when modifying the cyclohexane so it's not an arylcyclohexylamine anymore? (Not that I'd support that RC business shit really, more to see how lazy they are indeed.. I definitely have to find other, better ways to get my hands on good chemicals than throwing money at mad RC capitalists...)clubcard said:Last edited:
dopamimetic
Bluelighter
What reference, regarding the UK laws? Not really, as I'm not living there.. and I'm lazy sometimes
Don't understand why the UK is so important for the European (and even worldwide) RC market though. There are countries with better legislation..
(But why the hell are they then putting so much energy into things like mexedrone ..8()(d)[21] 1-Phenylcyclohexylamine or any compound (not being ketamine, tiletamine or a compound for the time being specified in paragraph 1(a) of Part 1 of this Schedule) structurally derived from 1-phenylcyclohexylamine or 2-amino-2-phenylcyclohexanone by modification in any of the following ways, that is to say,
(i)by substitution at the nitrogen atom to any extent by alkyl, alkenyl or hydroxyalkyl groups, or replacement of the amino group with a 1-piperidyl, 1-pyrrolidyl or 1-azepyl group, whether or not the nitrogen containing ring is further substituted by one or more alkyl groups;
(ii)by substitution in the phenyl ring to any extent by amino, alkyl, hydroxy, alkoxy or halide substituents, whether or not further substituted in the phenyl ring to any extent;
(iii)by substitution in the cyclohexyl or cyclohexanone ring by one or more alkyl substituents;
(iv)by replacement of the phenyl ring with a thienyl ring.”.
(e) Any compound (not being a compound for the time being specified in paragraph 1(ba) of Part 1 of this Schedule) structurally derived from 1-benzofuran, 2,3-dihydro-1-benzofuran, 1H-indole, indoline, 1H-indene, or indane by substitution in the 6-membered ring with a 2-ethylamino substituent whether or not further substituted in the ring system to any extent with alkyl, alkoxy, halide or haloalkyl substituents and whether or not substituted in the ethylamino side-chain with one or more alkyl substituents.”.
2. Any stereoisomeric form of a substance for the time being specified in paragraph 1 of this Part of this Schedule.
3. Any salt of a substance for the time being specified in paragraph 1 or 2 of this Part of this Schedule.
4. Any preparation or other product containing a substance or product for the time being specified in any of paragraphs 1 to 3 of this Part of this Schedule, not being a preparation falling within paragraph 6 of Part I of this Schedule.Cyclohexyl or cyclohexanone ring.
So a Thiane or Oxane are both legal - I gave a reference to the QSAR and the S increases potency.
'The search for TCP analogues binding to the low affinity PCP receptor sites in the rat cerebellum'
Jacques Hamona, Florence Espazea, Jacques Vignonb, Jean-Marc Kamenkaa
Eur. J. Med. Chem. 34 (1999) 125−135
Compound 10(+)IC50 5.2
PCP IC50 23
MK-801 IC50 6.4
The dose is dependent on the LogP of the compounds. Whatever - it WILL be very potent but a simple MXE replacement with a thiane would be VERY similar in dose & effect (likely shorter duration but into an opioid)Last edited:
Nagelfar
Bluelight Crew
of IPPD just think that it'll be harder and less lucrative to get a substance approved that is known to have 'abuse' potential and gets compared to coke (it's actually better, but I didn't say that )
I'd have figured the phenyl to be too short for the serotonergic glow that many who prefer cocaine go for. Perhaps Isopropylnaphthidate would be a good avenue?
dopamimetic
Bluelighter
Admitted, I'm often co-administering something serotonergic ... MXE (great but probably not to be taken lightly), venlafaxine, etc ... I'm unsure if past SSRIs messed my 5-HT up and/or if it's really the case, but MPH or d-amph alone feels very cold, wired and mechanic to me.. it's much less pronounced with IPPD but still there.
HDMP-28 was an utter failure for me, so I didn't really think about isopropylnapthidate (and afaik it's not yet clear whether the naphthalene group might be harmful here)... but I'm curious of course
dopamimetic
Bluelighter
Shouldn't the reverse ester just have comparable effects to the original? Since I've tried IPPD, I don't want to touch the MPH/EPH/etc. again ... will search for that compound, a welcome exercise to refresh my French skills. I've lived in Southern France for some time.. it's a nice place