N&PD Moderators: Skorpio
Phenyltropanes
Nagelfar
Bluelight Crew
Hey, I'm wanting to finish WP banned user Nuklear's WP: list of Phenyltropanes page. Clean it up, organize it better. If someone could help glean through the 1st section of this paper (mirrored here) and find what number - through to -what number PTs aren't already included on the WP list page, I'll do all the work including them. Also, alternate sources of novel PTs are welcome.
If you lose the whole ester group of RTI-55 and use the p-nitro, you end up with something that is identical in action as coke. The more electronegative the better. This is one area where synthetics are good. They stop (or at least vastly slow down) the murders in Mexico and all points south. Potency is identical to pure coke & it even gives the numbing effect. If US chemists (for a 'cook' won't manage this) made it, it's equally toxic to cocaine BUT it doesn't come with a side-order of levamisole. SO FAR, 150 tonnes of coke has been seized in 2015 in the US. I don't like it anyway but if this were made, it would be the more ethical choice. The synthesis doesn't involve any illegal compound either.
sekio
Bluelight Crew
Thought the benzoate ester was needed for anesthetic effect and shit like troparil, RTI55 are not numbing sodium channel blockers? Or is it just a crazy potent vasoconstrictor? (in that case, it may not be any nicer than cocaine)
Nagelfar
Bluelight Crew
Whoah, whoah, slow down guys. I'm looking for *attested* phenyltropanes. Is your non-ester p-N RTI-55 sourceable, clubcard? Sounds interesting. AFAIK, like sekio, the bridge has to be more complex than the phenyl(tropane) to be a NAv blocker
I don't know about RTI-55 but the p-nitro analogue is a local anesthetic and about twice as strong a pure coke (i.e. 3-4 x more potent as street coke). It gives the numb, it gives the rush, It has the same duration of cocaine (EWG groups are the secret & the -NO2 is reduced flushing it from the brain).
Of course - my question to ANY chemist is 'would YOU take it?'. It's legal to make but I expect bulk coke to be much cheaper - I have no idea of the deaths called levamisole and the limited effectiveness of tests (people who have just paid £60/g refuse to waste it... and cocaine is waste at ANY TIME in my opinion).
Nagelfar
Bluelight Crew
Forgive my hobbyist laymanism over a large swathe of the simpler notions and such: Please clarify this for me, as I am not formally educated in this and have gleaned everything as I have gone: m- vs. p- is a location intrinsic to the given compound according to its structure or isomerism? This means you place the nitrogen elsewhere? Could you draw a simple phenyltropane as is usually rendered, and give a 2D of one that is p-nitrogen? Thank you, quite an amateur request perhaps but that is exactly what I am in all honesty, behind the fog of the computer screen, this has been something I've been parroting for eight or so years and that's all.
Nagelfar
Bluelight Crew
So, as I've figured previously (but wonder still if there is more to it,) the p- vs. m- nomenclature is just the 4' versus the 3' position, respectively? Where does the terminology come from, if I may be/can be so educated
roi
Bluelighter
https://en.wikipedia.org/wiki/Arene_substitution_pattern
Paramethoxyamphetamine (PMA) = 4-Methoxyamphetamine
?
Just lose the WHOLE ester function - see RTI-155
They messed with halogens & alkyls but no nitro or -CF3 were tried. I KNOW the p-nitro has the freeze & the rush (I didn't try the freebase myself, but smoking it is apparently better than crack.
F&B tried the p-F analogue and was impressed - the p-nitro is better. The only worry is an aromatic amine may well be formed.
dopamimetic
Bluelighter
This one wikipedia page alone provides enough structures to keep the RC business alive for quite some time
dopamimetic
Bluelighter
I don't consider long durations to be straightly bad, but well I'm not really chasing kicks either. Perfect drugs build a plateau of effects that lasts all day long before fading smoothly imo
so one doesn't think constantly about redosing and all that but is free to enjoy the effects and enhancements the substance offers..
Nagelfar
Bluelight Crew
RTI-55 or RTI-155? (if the former, just a nitrogen, that simple eh?)
BTW could someone draw the following PT for me? -
"β-(4-Methoxyphenyl)tropane-2β-carboxylic acid 2-(3-iodo-4-aminophenyl)ethyl ester"
stated "with an IC50 value of 2.5 nM for the DAT and Ki values of 3.5 nM and 2040 nM for the 5-HTT and NET, respectively" sourced here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841478/
It's inbetween RTI-83 & RTI-11w, and I find it interesting for that reason.
EDIT:
In terms of more electronegative, how is a good way to make it so, can be it anywhere in the compounds structure? Such as, adding oxygens in places that won't interfere with direct binding? Has neon ever been put in a drug to good effect? ;-p
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roi
Bluelighter
I don't consider long durations to be straightly bad, but well I'm not really chasing kicks either. Perfect drugs build a plateau of effects that lasts all day long before fading smoothly imo
so one doesn't think constantly about redosing and all that but is free to enjoy the effects and enhancements the substance offers..
My point was that it was a reasonably simple compound that's just like coke. You get the freeze, you get the high, you will redose until it's all gone. It's a simple question of toxicity. Is the p-NO2 more dangerous than the levamisole?
Nagelfar
Bluelight Crew
Nagelfar
Bluelight Crew
By the "ester function" do you mean the carbmethoxy? I've seen analogues that work with that omitted entirely. I'm more confused now. Can't you just draw it at www.chemicalize.org, hit "PrtScn/SysRq" to the right of F12 and hold cntrl and hit V at www.snag.gy, and link the image here from the address it gives you after you crop the image? That's what I do. ;p
? :-j
Forget pin the tail on the donkey: it's pin the substitution on the phenyltropane!
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