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Fluoxatine isomers

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Bluelighter
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Apr 12, 2013
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Hi,
Has anyone got the Ki on norepinephrine uptake for each isomer?

Fluoxetine & Atomoxetine are veeerryy similar and while prozac is supposed to be highly selective, it feels like an NRI to me. Actually, quite surprised that the makers didn't patent the isomers to extend their control over the market. After all, this is a standard trick and has been applied to other antidepressants.

Thanks all
 
Strong SSRIs can be very stimulating indeed, at least in the beginning. With paroxetine, even at just 20mg/d, I felt hyper-energetic like never again (with the only exception of the dangerous combo of bupropion + DXM). The second week felt like I did not sleep at all and things like zopiclone did just nothing. At the end of this week I experienced symptoms of severe sleep deprivation including hallucinations and finally stopped.

In retrospective and after talking with many fellow sufferers and reading about the science behind I have the strong feeling that if one reacts like this from an SSRI, it should be seen as a red alert saying whatever symptoms exist, they aren't due to low serotonin levels and continuing the SSRI will lead to tolerance along with lethargy, exacerbated depression and/or anxiety, impulsivity and eventually a nasty withdrawal at the end.

I had to learn this the hard way, as have many others as well.
 
Strong SSRIs can be very stimulating indeed, at least in the beginning. With paroxetine, even at just 20mg/d, I felt hyper-energetic like never again (with the only exception of the dangerous combo of bupropion + DXM). The second week felt like I did not sleep at all and things like zopiclone did just nothing. At the end of this week I experienced symptoms of severe sleep deprivation including hallucinations and finally stopped.
Click to expand...

So I have no experience with Prozac but I've been taught that it takes ~6 weeks for the subsequent gene regulation to acheive a therapeutically stable effect. Do you think you would've had better results if you had stuck with it?
 
dopamimetic said:
Strong SSRIs can be very stimulating indeed, at least in the beginning. With paroxetine, even at just 20mg/d, I felt hyper-energetic like never again (with the only exception of the dangerous combo of bupropion + DXM). The second week felt like I did not sleep at all and things like zopiclone did just nothing. At the end of this week I experienced symptoms of severe sleep deprivation including hallucinations and finally stopped.

In retrospective and after talking with many fellow sufferers and reading about the science behind I have the strong feeling that if one reacts like this from an SSRI, it should be seen as a red alert saying whatever symptoms exist, they aren't due to low serotonin levels and continuing the SSRI will lead to tolerance along with lethargy, exacerbated depression and/or anxiety, impulsivity and eventually a nasty withdrawal at the end.

I had to learn this the hard way, as have many others as well.
Click to expand...
Actually, those are the kind of symptoms that cause depressed people to commit suicide after taking SSRIs. They should always be discontinued if they make you feel like that. It's not a typical reaction.
 
I thought I had fucked up because I WAS taking hyperforin BUT I had only 10mg and 72 hours later, I'm still having to use benzos to keep calm.

On reflection, the hyperforin is an NRI but I had NO stimulant effects. Even with a 24 hour gap, It was like p-F Aminorex (shudder).

Problem is, being bipolar, you CAN still get unipolar depression (they feel quite distinct) so now a 3 month wait to see a consultant to ask for Lamotragine - it works on unipolar & bipolar depression BUT isn't licensed for unipolar depression in the UK... so 3 months of depression followed by the crawl up the ladder of lamotragine just HOPING it works. If not, I guess I'm through.
 
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