pr0d1gy
Bluelighter
- Joined
- May 1, 2009
- Messages
- 547
I know surely there must be a plethora of literature about various derivatives of tramadol having different n-substituents. I don't have experience searching this kind of literature and frankly don't want to use the search engines available to me to do so. I am wondering what changes in activity might occur if the dimethylamino moiety were altered to diethylamino or cyclicized to piperidine or pyrollidine.
I'm mostly interested in the possibility of the n-diethyl analog. Based on data from some pethidine derivatives I think this may hold some possibility of being worthwhile. Would these and their o-demethylated counterparts be weaker mu-agonists?
I'm mostly interested in the possibility of the n-diethyl analog. Based on data from some pethidine derivatives I think this may hold some possibility of being worthwhile. Would these and their o-demethylated counterparts be weaker mu-agonists?