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Effects of medications on sensory gating (noise sensitivity)

medimate9

Greenlighter
Joined
Jan 3, 2015
Messages
7
Hello everybody

I read that tabacco smoking increases sensory gating for 30min. and that it is one reason why people smoke tabacco.

Question:
Does Galantamine improve sensory gating with Risperdal's efficacy without causing memory impairment?

Details:
I am looking for a medication which improves sensory gating like nicotine does without creating addiction, or like Risperdal does without the side effects of having impaired visual and auditory memory.
It would be great to chat live with someone someday who uses Galantamine or knows more about sensory gating!
I have had the privilege to try out Risperidone (from 0.25mg - 1mg) several times and Aripiprazole (from 2.5mg - 20mg) for theirs effects on sensory gating and was disappointed by memory impairment and other side effects.

This is just personal experience, but my focus is better on Risperidone than Aripiprazole in terms of task persistance. Sensory gating, p50 Amplitude values are said to improve according to studies, and that is how it felt. I can program code in the train with Risperidone (0.5mg) even when noise level is extreme. Extreme noise levels like a emergency car signal very close or shouting children close to one's laptop are just no more cause for disruption. The drawback of Risperidone, which I find very discomforting is that the cognitivefun.net/test4 average score decreases significantly. Also other tests on span and memory are reduced a lot.
I tried out Invega (Paliperidone, 3mg) the "improved Risperidone" and it diminishes memory to a lesser degree.

I believe that overall results in cognitive tests while being on Risperidone for me during those few experimental settings were worse than Aripiprazole in cognitive and metabolic side effects.
I would take Risperidone only in rare situations to obtain higher task persistence and better sensory gating.

With Aripiprazole the effect on sensory gating is hardly noticeable. I notice significantly more startle-reaction in the train when people talk on Aripiprazole than on Risperidone. Risperidone makes me focused but also more forgetteable and less able to show empathy.

My dream would be a medication which increases the ability to filter out irrelevant signal (PPI, p50 amplitude, sensory gating)
without impairing cognitive functions. Nicotine, Risperidone are no long-term possibilities for me. So please if anyone knows about this topic, help me!

Best regards
Matt
 
Sorry I don't have an answer, however I am curious as to what practical reason you have for wanting to do this? If anything taking Risperidone for this reason would be akin to taking oxycodone for depression. Sure, you might solve one problem but create ten others in the process. I guess this is the reason you are looking for one with less side effects, but I'm still wondering what purpose you'd use it for.
 
"but I'm still wondering what purpose you'd use it for."
It all comes down to the ability to filter out irrelevant signals e.g. auditory noise by shouting children in your train compartment.
This ability is in the literature described as "sensory gating" or "prepulse inhibition" (no details I am an amateur". It is measured with tests such as the p50 amplitude.
(more info here: http://en.wikipedia.org/wiki/Prepulse_inhibition)
Most people have decent sensory gating and will never need any improvement, but I happen to be more sensitive in this regard.
 
Yeah, and it is an improvement.
I am curious though how Galantamine's effects are through allosteric potentiation of nicotinic acetylcholine receptors.
Is there anybody who has tried Galantamine?
 
Yeah, and it is an improvement.
I am curious though how Galantamine's effects are through allosteric potentiation of nicotinic acetylcholine receptors.
Is there anybody who has tried Galantamine?

I'll try it and get back to you. Ever since getting ODed with LSD I've had a bad problem with sensory gating, but looked up solutions, thinking it was just a consequence I have to live with. Good read your post was.

I'll be in touch amigo. Let me know what you come up with ok? Thanks
 
Hi
It is great to find eventually someone who knows the term "sensory gating"!
It would be great to chat about this live on skype (my ID is medimate9), because I have a lot of questions which might not be relevant for this forum.

There must be a compound, pharmacological configuration, which brings in the advantage of 0.5mg Risperidone in terms of increased filters and inhibition without the loss of memory performance. Between Aripiprazole and Risperidone I feel there is a huge difference in this regard.

A good way to assess one's cognitive side-effects is playing the visual memory test on: http://cognitivefun.net/test/20
I don't think one should use on long-term any medication which significantly impairs one's tests results unless one has a serious condition such as schizophrenia.

medimate9
 
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