morphine/codeine dosage conversion

[kaosisallwesee]

My friend gets oramorph and i get codeine. we argue over which is better orally, he insists morphine, I say codeine.

My reasoning for this is this...

I was reading about the BA of morphine and 10% is pretty shitty, now codeine is a pro-drug to morphine and converts at a rate of 10% in the average person.

so wouldn't 100mg, for eg, of each be equivalent to eachother? In terms of amount of morphine ending up in the blood stream?
If this is the case why are doctors so clueless when it comes to dosage for oramorph?
My mate has Hodgkins lymphoma, hes had it for 6-7 years and constantly undergoing treatment, he gets 600ml of oramorph for every 10-14 days.
Hes meant to take 5-10ml (10-20mg) as a dose, no more than 50ml (100mg) a day.
100mg would only be 10 mg when not plugged/injected, so he just drinks it like water.

 

[knockout]

Hi,

Suddenly I found this:
http://www.bluelight.org/vb/threads/564885-Opioid-Conversion-Chart
I hope, it helps.

knockout

 

[kaosisallwesee]

Hi,

Suddenly I found this:
http://www.bluelight.org/vb/threads/564885-Opioid-Conversion-Chart
I hope, it helps.

knockout

Thanks for the reply man, trouble with conversion charts is that they always treat oral morphine as more than it is.
30mg of morphine is no where near 200mg of codeine ime. (codeine being the better one at though's doses)
consider the amount of morph. actually reaching your blood, it'd be like 3mg, if the BA for oral use is correct (10%)
and 200mg of codeine would end up as roughly 20mg of morphine. (10% conversion rate)

Just trying to get some peoples exp. as to which is a better oral opiate, as they both, dose for dose, end up with same amount in the blood stream, don't they?

 

[pally pete]

Codeine.

It's cheap, easy to get hold of and gives a good buzz if you don't do it that often.

 

[Jktm]

Morphine sulfate is a better analgic. That 100mg of Morphine Sulfate is equivalent to a gram of codeine by old standards. But that figure derived from the factor if 10 from 10% of codeine is metabolized into morphine comes before the realization that 6-glucoronide-codeine has any activity.