Bupe Suboxone RoA and its full potential.

[mabzie55]

Before I begin, I just want to say that before someone comes in saying "Just do a full agonist if you want a buzz"-- no thanks, I'm not touching real opiates ever again... Hence why I'm on bupe to begin with.


I've been on Suboxone for about two years.
My current dosage is between 4 and 8 mg per day. (Sometimes, rarely, a higher dose than that)

I basically only get a slight warm buzz feeling for about 20-40 minutes after it has dissolved (strips).

I've been thinking lately about alternative routes of administration, and have a few questions:

1. With taking a decent dosage for so long, could my receptors be filled up to the point where a RoA with a higher bioavailability would still not give a noticeable boost to effects?

2. Is nasal feasible with strips?

3. Rectal? How do you go about this?

4. Chemical differences with rectal RoA that could lead to stronger effects?

And any general information/tips relating to this subject would be appreciated.

 

[mabzie55]

Also, if it would make me feel it more, is the difference pronounced enough to make rectal administration worth it?

 

[burn out]

What you need to do in order to get high on suboxone is take your dosage way, way down, otherwise your receptors remain just too dang saturated. Other routes of admin ain't gonna help you much, if at all, because your problem ain't got to do with with ROA but saturation. What I recommend is get off sub and taper using kratom for a week or so, get your opiate tolerance down real low. Then you will be able to get high on suboxone again. Suboxone and kratom are both great opiate replacements. They work real good. However, they both cant be abused like real opiates and so getting high off them requires patience. If one is patient one get can high on these drugs, but if one is greedy and treats them like full agonists then such a person will only crave full agonists.

 

[HellishCycle]

A higher dose will not give you a better opiate feeling buzz, even with rectal roa. Rectal admin. Will enhance that small buzz feeling you get, and it lasts just as long. But beware it is addicting. What I did for a few months was take a normal syringe for banging dope and took the point off, mixed the sub with a little water, not too much. Lay on your stomach, insert an inch or two, and slowly push the solution inside. Hold yourself together for a little bit before you get up because you don't want any leakage. After 2 Or so minutes you should be fine and and 15 min later you'll feel that same subtle buzz the subs give you when used normally. Nothing exciting but it still is slightly increased. You should try it once and see if you think it's worth it or not. It was worth it for me for a short period of time until I decided I needed to stop the addictive behavior and went back to regular roa. So bottom line you have to ask yourself if it's worth it after you try it.

 

[ThaDudeAbides]

I've taken 8mg oral and puffed some weed and got great highs. I honestly prefer oral as the ROA. Seems to last longer. 8mg can get me through 3 days.

 

[The Doc.]

Wait a full antagonist?? You must mean a full agonist. An antagonist is something that reverses the high such as naloxone.

 

[mabzie55]

Wait a full antagonist?? You must mean a full agonist. An antagonist is something that reverses the high such as naloxone.

Yeah that's what I meant.
God damn it.
I'm always on my phone and I never catch typos/mistakes/false autocorrect until I read my posts like 2 weeks later.

 

[dirzted]

just read the megathread- answers most of your questions on the first page

 

[burn out]

I've taken 8mg oral and puffed some weed and got great highs. I honestly prefer oral as the ROA. Seems to last longer. 8mg can get me through 3 days.

Oral is the best also, imo, for a long lasting high but I iv the strips in order to make each one last longer and also it wears off sooner that way meaning you can get high again sooner. But if I had no opiate tolerance and got a strip, I would probably go oral for the long high.

 

[dirzted]

Oral is the best also, imo, for a long lasting high but I iv the strips in order to make each one last longer and also it wears off sooner that way meaning you can get high again sooner. But if I had no opiate tolerance and got a strip, I would probably go oral for the long high.

I hope by "oral" you mean sublingual...

 

[burn out]

Yes I do mean sublingual although when people talk to me and I have to talk back with a strip under my tongue it dislodges it and I think I end up swallowing. Use to drive me nuts when I would have to take suboxone at work and I would just put a strip in and then my boss would mosey on over and want to have a conversation.

 

[The Doc.]

Yes I do mean sublingual although when people talk to me and I have to talk back with a strip under my tongue it dislodges it and I think I end up swallowing. Use to drive me nuts when I would have to take suboxone at work and I would just put a strip in and then my boss would mosey on over and want to have a conversation.

Haha yea that sucks I would make a solution with water and drip that under the tounge instead. All you do is just take a tiny bit of water in a bottle cap and drop a strip or tablet whatever you have into it till it dissolves then use a dropper to drip it under the tounge. It increases bioavailability and makes it easier to talk with less saliva. Its easier to talk too but if saliva builds up and you see your boss coming spit it into a empty cup you grab before hand just for this purpose then when he leaves you can take it again with no waste. I cant swallow my suboxone saliva after my pill is dissolved because it hurts my stomach and causes more naloxone to be absorbed through the stomach which decreases the buzz I feel. Buprenorphine has extensive first pass metabolism meaning most of the drug gets destroyed by the liver before it can reach the brain so swallowing bupe only gets about 10 percent absorbed versus 40-50 percent when taken sublingual.