Alcohol shakes vs. ketamine shakes, cessation

[.:Holy::Toast:.]

After quitting my ketamine habit a week ago, I developed bad twitches and shakes and they have slowly been dissipating, however I'm wondering if the mechanism for these shakes is caused by the same mechanism as alcohol shakes, namely, more specifically could stimulation of NMDA receptors be the culprit?
Futher more ketamine, as far as I know, has never been shown to cause seizures like alcohol can upon cessation, are the causes for shakiness and seizures separate?
Just a quick theory is that the seizures are regulated by GABA, as benzo withdrawal can also cause seizures, but as ketamine does not act on GABA is this the reason why seizures are not seen after ketamine abuse but the shakiness can?

 

[Solipsis]

this is what I personally think is going on:

Since GABA and glutamate are two sides of the same coin, a closely intertwined excitatory and inhibitory system... it should not be surprising that we see some similar phenomenon when A) GABAergics are discontinued causing insufficiency of the inhibitory system, and B) NMDA antagonists are discontinued causing - I think - ill regulated glutamatergic excitation. But the latter is apparently not enough to cause highly irregular electrical brain activity leading to seizures, while insufficiency of the inhibitory system can indeed apparently allow for that to happen. Because, that inhibitory system does not just 'counter' glutamatergic activity but attenuates a lot of other activity, rather in general.

Normal GABA activity in the brain is I think key in suppressing all sorts of things including seizures, you could call that regulation. Seizures appear to be caused by malactivity / overactivity of the excitatory neurotransmitters like serotonin and other monoamines / catecholamines. Maybe it's just me, but I tend to see a lot of serotonin involvement when drug-related seizures are considered. I think seizures are pretty much a global event, and the neocortex may be included. Serotonin is particularly relevant for that 'higher brain'.

I think twitches and shakes are rather local issues say of the motor cortex, maybe PNS. I couldn't really say what is badly controlled when twitches happen - muscular ion channels for example? I'd be interested to know why GHB in some 'stages' of the experience can cause twitchy jolts.
Also I guess shakey twitches are not the same as hypermobility such as on a very high dose of a stimulant. Again in some ways two sides of the same story, but there kind of seem to be differences between A) the sympathetic nervous system being in overdrive out of the control of the parasympathetic nervous system which is at normal levels.... and B) there being insufficiency in the parasympathetic nervous system (because it was relying on being helped by downers that are being discontinued).

 

[dopamimetic]

Maybe it's just me, but I tend to see a lot of serotonin involvement when drug-related seizures are considered

Thinking of these awful brain zaps emerging after SSRI discontinuation (and after one has had them once, they come back every time a serotonergic is involved.. DXM, methoxetamine, from reports of others also MDMA, mephedrone, etc..) I agree to that. They really feel like mini seizures which luckily get halted before they escalate.

Also there exists acamprosate, which is said to aid in restoring balance of glutamate and gaba after alcohol withdrawal. Maybe this could help with NMDA antagonist cessation too?