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Misc Quitting Seroquel & Using Diphenhydramine

5_HT2A

5_HT2A

Bluelighter
Joined
Jun 11, 2014
Messages
67
I take Seroquel XR 600 mg. Seroquel XR has extremely high affinity for H1 (4.41 and 1.15 for norquetiapine), it has a tmax of 6 hours and I believe the steady-state mean cmax of AUC and norquetiapine is 21%-27% and 46%-56%. So how much diphenhydramine can I take in place of Seroquel so I can sleep? I mainly only get histamine related withdrawals.
 
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Bump. idk if wtf I said makes any sense. My cognition is complete shit because of this shit. I just need to know how much benadryl I can take in place of shit Seroquel to not suffer histamine related withdrawal/rebound effects.
 
bump no one? i don't wanna take so much diphenhydramine that I have no cholinergic activity at all. I just want to sleep. Life is fucking hell right now.
 
No More than 100MG Per Night 150MG+ you just get Opposite and BAD HALLCUINATIONS.
 
5_HT2A said:
I take Seroquel XR 600 mg. Seroquel XR has extremely high affinity for H1 (4.41 and 1.15 for norquetiapine), it has a tmax of 6 hours and I believe the steady-state mean cmax of AUC and norquetiapine is 21%-27% and 46%-56%. So how much diphenhydramine can I take in place of Seroquel so I can sleep? I mainly only get histamine related withdrawals.
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You need to taper off the seroquel slowly, my son. Diphenhydramine won't be an adequate replacement to prevent withdrawals on its own. Talk to your doctor/psychiatrist, start the taper, talk to him about trying something else (trazodone, mirtazapine, benzos)
 
Ondine said:
You need to taper off the seroquel slowly, my son. Diphenhydramine won't be an adequate replacement to prevent withdrawals on its own. Talk to your doctor/psychiatrist, start the taper, talk to him about trying something else (trazodone, mirtazapine, benzos)
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Tried trazodone, caused insomnia lol. I might ask for mirtazapine to help with taper since it has pretty similar pharmacodynamics (not so much in terms of how tightly it binds, but similar receptor interactions). You think I could go from 600 mg to 300 mg in one night and take like 100 mg diphenhydramine? I want to get off quickly and lose a few pounds. Gotta look good before going back to school haha. I'm 16 and don't want to be on antipsychotics anymore.

EDIT: I wonder if the Seroquel will prevent the diphenhydramine from even binding to H1. I don't know a lot about pharmacology though. Only basic neurology and a few other things.
 
I've been on Seroquel for years - am interested in how this goes for you as I would like to get off of it (after I kick heroin that is), as I'm scared as I cannot sleep without it. Trazadone also keeps me up, but that is just me. All I do know is in switching drugs, one needs to slowly titrate the new one while steadily tapering the other... slowly.

Of course talk to your doctor. Another alternative is another antitypical than Seroquel to switch to that doesn't cause weight gain (not that others help sleep as well, but some do), then in the interim and it will be easier to get off it as your system isn't accustomed to it for such a long duration. I had a psychiatrist for years and this was his suggestion for med changes. Also, prescription antihistamines don't cause dry mouth as much as otc. as well as other troublesome side effects. Not as many anyway. :)
 
Smoky said:
I've been on Seroquel for years - am interested in how this goes for you as I would like to get off of it (after I kick heroin that is), as I'm scared as I cannot sleep without it. Trazadone also keeps me up, but that is just me. All I do know is in switching drugs, one needs to slowly titrate the new one while steadily tapering the other... slowly.

Of course talk to your doctor. Another alternative is another antitypical than Seroquel to switch to that doesn't cause weight gain (not that others help sleep as well, but some do), then in the interim and it will be easier to get off it as your system isn't accustomed to it for such a long duration. I had a psychiatrist for years and this was his suggestion for med changes. Also, prescription antihistamines don't cause dry mouth as much as otc. as well as other troublesome side effects. Not as many anyway. :)
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I've got some Cyproheptadine HCl, would that work? I took Clonidine HCl just now because I can't hit my e-cig without chest pain, I think it's rebound hypertension from the alpha-1 blockade.

Also, my plan is to switch to aripiprazole if I absolutely have to. That and ziprasidone cause minimal cardiometabolic issues. I'm also considering buying phenibut to help sleep but that shit is extremely addicting as well. Life sucks... lol
 
Thomas29 said:
No More than 100MG Per Night 150MG+ you just get Opposite and BAD HALLCUINATIONS.
Click to expand...

Well my H1 and M1/M3 receptors are presumably hypersensitive due to the quetiapine, therefore I don't anticipate hallucinations even with a very high dose. You think I could go for 200-250 mg? I don't care about cognitive impairment at the moment, just getting through the day not manic, paranoid and sleep deprived. Just thinking. Again, I don't know a lot about pharmacology :p.
 
I also drank 2 beers, 3 shots of gin. I'm currently paranoid of shadows, closed doors, and movement of almost any type. Slightly energetic with inflated interest. Basically how I felt on Vyvanse once amphetamines lost all positive effects. Took 100 mg of diphenhydramine as well. Might take cyproheptadine and a vasodilator of some sort.
 
If I take pseudoephedrine, will it help with potential bradycardia? I only took 0.1 mg of clonidine.
 
^^^ You should be more worried about Tachy Cardia with 200mg+ of fucking Benadryl. Jesus man, come on.

First off, I don't know where you got those figures from, diph and seroqeul have roughly the same affinity for H1 receptors. Secondly, the delirium from diphenhydramine is not caused by H1 antagonism, it is the result if it's anti-cholinergic activity.

WD symptoms from 600mg of seroquel(Q), cannot be treated with megadoses of a 1st gen H1 antagonist. I repeat, ANTIHISTAMINES ARE NOT A SUBSTITUTE FOR LARGE DOSES OF SEROQUEL.

Seroquel is an antipsychotic, despite how ineffectual it may be in small doses used for sleep, at larger doses(200-800mg) it is indeed a quite competent dopamine/ serotonin antagonist.

Diph isn't going to cut it in that regard. I'd strongly advise taking a few days to taper the doses. Also going even 72 hours without any CNS active H1 antagonist's will cause your tolerance to the hypnotic effect to drop incredibly fast. After that, I would try 12.5-25mg doxylamine to help with sleep.(absolute max 50mg).

And not to be rude, but at 16, you're hardly qualified to make these kinds of adjustments without assistance. :)
 
Since Seroquel is not a cns depressant I am not sure clonidine would help. Not that one's blood pressure wouldn't rise from anxiety and lack of sleep regardless of the drug. I take it for withdrawals but the clonidine is directly related to the type of med that will spike my bp to bring it down. I just learned something myself. I didn't know Seroquel had affinity for H1. Lorne seems to have alot of information. I would be careful and not drop anything suddenly. I've done that before and I regret not tapering... Just IME :)
 
Lorne??? said:
^^^ You should be more worried about Tachy Cardia with 200mg+ of fucking Benadryl. Jesus man, come on.

First off, I don't know where you got those figures from, diph and seroqeul have roughly the same affinity for H1 receptors. Secondly, the delirium from diphenhydramine is not caused by H1 antagonism, it is the result if it's anti-cholinergic activity.

WD symptoms from 600mg of seroquel(Q), cannot be treated with megadoses of a 1st gen H1 antagonist. I repeat, ANTIHISTAMINES ARE NOT A SUBSTITUTE FOR LARGE DOSES OF SEROQUEL.

Seroquel is an antipsychotic, despite how ineffectual it may be in small doses used for sleep, at larger doses(200-800mg) it is indeed a quite competent dopamine/ serotonin antagonist.

Diph isn't going to cut it in that regard. I'd strongly advise taking a few days to taper the doses. Also going even 72 hours without any CNS active H1 antagonist's will cause your tolerance to the hypnotic effect to drop incredibly fast. After that, I would try 12.5-25mg doxylamine to help with sleep.(absolute max 50mg).

And not to be rude, but at 16, you're hardly qualified to make these kinds of adjustments without assistance. :)
Click to expand...

I realize the delirium is from its anticholinergic activity.

I only really get histaminergic withdrawal symptoms so I assumed I could use diphenhydramine with a taper, or as a replacement.

I slept a few hours, very shitty sleep, but still I managed to get some with diphenhydramine, alcohol (I know bad for REM and all the blood glucose issues), and clonidine.

I felt fine but I took one 300 mg XR tablet a few hours just to help the minor agitation.

I'm going to drop from 600 to 300, and do it by myself since my doctor is an asshole and doesn't listen to me.


Also, I understand I can't really make these decisions without assistance, that's why I'm asking here. I appreciate the tips :)

* Sorry for my poorly constructed sentences, I suck at English even though it's my native language haha, and I get worsened impairment from Seroquel and anticholinergics.
 
Start low. These two drugs shouldn't have a cross tolerance. I take 50mg for sleep nightly. , if you start high you'll developed a tollerance to its sedative effects quicker
 
I'm having hypertension from cold turkeying this shit. 145/90. cold sweats, dizzy, headache, veins incredibly fucking thin. arm pain all that shit. I'm going to the ER so my heart doesn't stop or I get a stroke. I learned my lesson. Wean off this shit!!!! Cold turkey can KILL YOU
 
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