Phenylpropanolamine - CNS activity?

[pyttsan]

Does anyone know if phenylpropanolamine stimulates both the CNS and the PNS?
Wikipedia states that it's psychoactive but does anyone about affinities for different subtypes of adrenergic receptors?


Levoamphetamine is the strongest nootropic I've tried so far and I've so been looking for a pure noradrenergic drug that can be taken on an as needed basis - hopefully this old decongestant could be it!

 

[DL-ark]

You could also try swallowing afrin, it is a pretty strong adrenergic, and if you swallow it you wont have the rebound effects of nasal administration. I actually don't know if it is active orally though.

 

[pyttsan]

You could also try swallowing afrin, it is a pretty strong adrenergic, and if you swallow it you wont have the rebound effects of nasal administration. I actually don't know if it is active orally though.

Oxymetazoline (active substance in afrin) only affects the PNS, if I'm not mistaken.

 

[sekio]

Phenylpropanolamine is just like ephedrine or cathinone; it crosses the BBB to act on monoamine transporters as well as acting on post-synaptic adrenergic receptors.

 

[WSH]

Phenylpropanolamine is just like ephedrine or cathinone; it crosses the BBB to act on monoamine transporters as well as acting on post-synaptic adrenergic receptors.

You specifically said POSTsynaptic adrenergic receptors. So it doesn't act on e.g. presynaptic alpha2 at all?

 

[pyttsan]

Phenylpropanolamine is just like ephedrine or cathinone; it crosses the BBB to act on monoamine transporters as well as acting on post-synaptic adrenergic receptors.

Do you know about the difference in selectivity for the different subtypes of adrenergic receptors? For example, ephedrine acts much more on the PNS than the CNS (ratio-wise) compared to levoamphetamine and probably leads to "adrenergic fatigue" much sooner.

If only someone could isolate levoamph.. then all my problems would be solved :/

 

[sekio]

I think it depends on stereochemistry. Just like (+/-)-ephedrine and (+/-)-pseudoephedrine, you can have both plus and minus cis/trans phenylpropanolamine. one of them will be active like ephedrine (central NET & post and pre-synaptic adrenergic Rs), one will be active like pseudoephedrine (mostly adrenergic Rs and no transporter affinity) and some will only be weakly active at adrenergic Rs (the "wrong" enantiomers which correspond to the compounds which would be reduced to laevoamphetamines).

See how there's two pairs? The hydroxyl (numbered 1 position on ephedrine) can either be up or down,. and the alpha-methyl (2 position on ephedrine) can either be up or down, so you have 4 in total. Both D- and L- (plus and minus-) pseudo and not-pseudo-ephedrine. 2S-ephedrine is the most potent isomer, the one that is the nasal decongestant active at 8mg that people reduce to meth... 2S-pseudo-ephdrine is what they put in cold pills. I'd assume 2S-nor-ephedrine is what people call phenylpropanolamine, but I'd imagine it could also be racemic. Who knows!

 

[endotropic]

Does anyone know if phenylpropanolamine stimulates both the CNS and the PNS?
Wikipedia states that it's psychoactive but does anyone about affinities for different subtypes of adrenergic receptors?


Levoamphetamine is the strongest nootropic I've tried so far and I've so been looking for a pure noradrenergic drug that can be taken on an as needed basis - hopefully this old decongestant could be it!

Why not Strattera - atomoxetine? Selective NRI, non-scheduled, no abuse potential. Prescribed for ADHD but in general less effective than traditional stimulants. It might be just what you're looking for.


edit: I should also point out that levoamphetamine isn't a selective NRI - it's a potent dopamine releaser as well, just less potent than dextroamphetamine. You might not find the same benefit with a selective NRI.

 

[DL-ark]

Why not Strattera - atomoxetine? Selective NRI, non-scheduled, no abuse potential. Prescribed for ADHD but in general less effective than traditional stimulants. It might be just what you're looking for.


edit: I should also point out that levoamphetamine isn't a selective NRI - it's a potent dopamine releaser as well, just less potent than dextroamphetamine. You might not find the same benefit with a selective NRI.

ewww atomoxetine makes me feel lethargic and sick.

 

[Dresden]

Vick's brand inhalers are 100% levo-methamphetamine if that helps you, but in my experience phenylpropanolamine is a fairly crappy drug.

 

[Limpet_Chicken]

Sekio, you seem to imply that the substance cooks reduce to meth, and the substance in cold pills are two separate entities.I suppose the occasional cook will get creative and biosynthesize their feedstock, or extract ephedra plant material to make their tweak, but its usually taken FROM cold pills as far as I know, certainly doing so is extremely common.

Personally I'd say PPA is too precious by far for use as a decongestant, what a waste of unborn 4-MAR

 

[sekio]

Sekio, you seem to imply that the substance cooks reduce to meth, and the substance in cold pills are two separate entities.

I don't mean this at all. As we all know the stuff in cold pills is the same pseudoephedrine that can be turned into meth with a pop bottle Birch reduction ...

 

[Limpet_Chicken]

Yeah I figured as much, its just the way things read in your prior post.

Those cola-bottle birches, I've heard about that, sounds bloody scary, given the vapor pressure of annie, and its corrosive, choking nature. Hell, I've read of rolling labs that have been discovered only when the bottle, which in the case(s??) I mean, were situated down the pants of the 'cook' built up too much pressure and exploded, presumably taking the unfortunate hack cook's scrotum and gonads with it.

It beggars belief what some people will do to get their fix..I mean..seriously. Birch reduction conducted in your underwear..what the everloving fuck. Even the most uneducated, aneuploid redneck hick trailer-trash fuckwit has to know that the liquified ammonia is corrosive, one breath anywhere near an open or badly sealed container will tell them that, and its blatantly obvious the stuff is below zero C (or Fahrenheit for the luddite yanks). Neither of which are obvious as candidates for good things to store down your kecks.

 

[sekio]

I don't think the "one pop bottle method" uses anhydrous ammonia, I believe it's generated in situ from reaction of lithium+ammonium nitrate.

 

[Limpet_Chicken]

Still, not something thats at all high up on my list of 'things to stick down your kecks whilst driving at high speed, gakked out of my face, down a fucking motorway' though.