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  • BDD Moderators: Keif’ Richards

Prescribed Hydroxyzpam for anxiety, does it affect GABA like benzos do?

ovo1024

Bluelighter
Joined
Sep 15, 2012
Messages
1,722
Location
Sacramento CA
so i have had anxiety problems for a few years now, im 21. i went to ER yesterday for a really bad panic attack. they gave me an iv of Ativan which helped but not completley it was 1mg i believe. they drug tested me which i only tested positive for opiates. ( i took a morphine 12 hours prior which i regret now) anyways as i got out they prescribed me Hydroxyzpam which he said was for anxiety. it helps a little but not much how does this medicine work for anxiety if its only a anti histamine like benadryl?
 
Also they are 50mg capsules to be tooken 3 times a day. i read they are water soluable so i can snort them right? not to get high but to get effects faster
 
Only in that they both act in some way on serotonin. It is more similar to nefazodone but I imagine the antihistaminic effects and subsequent sedation play a strong role in its usefulness in anxiety.
 
I was prescribed hydroxyzine w/ fluvoxamine. It did absolutely nothing in terms of anxiety. It did help w/ potentiation of dope and Xanax. It also did make me a bit sleepy from time to time. But this med is garbage if you want it to help w/ anxiety man.
 
Its called hydroxyzine. Besides being an antihistamne, it also has activity as a 5ht2a antagonist.

It's hydroxyzine pamoate so sometimes referred to as hydroxypam.

If you are expecting benzodiazepine or GABAergic effects, you won't find them there but it absolutely can help with anxiety. If you are looking for it to give you recreational effects then you will be even more disappointed than if you are looking for benzodiazepine-type anxiolysis.

I have found through years of BL use that BLers shit on absolutely every drug for therapeutic uses if there is an alternative with recreational use (atomoxetine or bupropion for ADHD over amphetamines; SSRI's, buspirone or hydroxyzine for anxiety; non-narcotic analgesics for pain, etc.). I think to a degree it's rationalization and people want their treatment with a side of recreational effects or at least the option to take a few extra and get high so they get pissed when they aren't given this.

Benzodiazepines are very effective, but in long-term use can exacerbate anxiety, cause some of the worst and longest lasting PAWS of any drug, cause horrible discontinuation syndromes (withdrawals) and many other problems. Hydroxyzine is far safer and has demonstrated efficacy in treating anxiety without most of the substantial drawbacks of benzodiazepines.

P.s.
BL is a message board, not a chat room. Responses take time. Repeatedly bumping your thread will not expedite responses. If anything, its counterproductive because it will annoy people as it appears you think your thread is the most important so many won't respond.
 
^^^ Right, I did not think of the pamoate part. I was thinking the OP may have thought it was related to benzos but that probably isnt the case.
 
^Yeah pretty much, its strong prescription strength antihistamine. If it has any effect on gaba receptors it is very slight. Quite popular to add to the nod of opiate highs.
 
Yeah, a fairly standard sedating anti-histamine, with effects not unlike diphenhydramine. Can be prescribed for anxiety, nausea/vomiting, insomnia, vertigo and related balance disturbances, and I'd guess allergy symptoms, though all the others seem to get it written for more often. I read once, in a quite dated book on psychology, it was sometimes used in the treatment of symptoms of alcohol wd's - seems counterintuitive to me, but the book was dated and even suggested that it was, potentially, a drug of abuse, but I can assure you no more so than diphenhydramine or the like.
 
It's the best anti-histamine I've tried and I can see how it's sedating properties could help with occasional anxiety. I actually got a short script for it to go along with my buprenorphine before and it definitely was no benzodiazepine, but it did have some properties I found helpful.
 
It's hydroxyzine pamoate so sometimes referred to as hydroxypam.

If you are expecting benzodiazepine or GABAergic effects, you won't find them there but it absolutely can help with anxiety. If you are looking for it to give you recreational effects then you will be even more disappointed than if you are looking for benzodiazepine-type anxiolysis.

I have found through years of BL use that BLers shit on absolutely every drug for therapeutic uses if there is an alternative with recreational use (atomoxetine or bupropion for ADHD over amphetamines; SSRI's, buspirone or hydroxyzine for anxiety; non-narcotic analgesics for pain, etc.). I think to a degree it's rationalization and people want their treatment with a side of recreational effects or at least the option to take a few extra and get high so they get pissed when they aren't given this.

Benzodiazepines are very effective, but in long-term use can exacerbate anxiety, cause some of the worst and longest lasting PAWS of any drug, cause horrible discontinuation syndromes (withdrawals) and many other problems. Hydroxyzine is far safer and has demonstrated efficacy in treating anxiety without most of the substantial drawbacks of benzodiazepines.

P.s.
BL is a message board, not a chat room. Responses take time. Repeatedly bumping your thread will not expedite responses. If anything, its counterproductive because it will annoy people as it appears you think your thread is the most important so many won't respond.

I think most people would argue that benzos are borderline recreational at best. They don't induce an opiate or amphetamine style euphoria, what they do do is kill anxiety, relax your muscles, and induce a state of sedation (to varying degrees, depending on the benzo in question). If you don't have anxiety to kill, muscles to relax or a need for sedation, then they'll just make you feel drowsy and messy. What doctors would describe as benzo ''abuse'' (putting aside their use to come down from stimulants - that's a different discussion) is generally just plain self medication in cases where the individual hasn't recognized their underlying problems, is under-medicated, is unable to find a doctor who will recognize their problems and treat them appropriately, or a small subset of the population (usually ignorant teenagers unacquainted with or unable to acquire more euphoric drugs) who will take anything which alters their consciousness just for the hell of it.

Not saying we should throw benzos around like candy, they do cause all the problems you describe, but they don't deserve to be put in the same category as opiates or or amphetamines, as they have zero appeal to someone who doesn't suffer from some level of the symptoms they're meant to treat in the first place.

As for non-benzo anxiolytics - they're often sporadic in their effect (with quite a bit of debate about the degree to which they actually help enough, and often enough, to deserve the label) and come with a host of side effects, many of which aren't much better than those benzos give.

The same could be said for pain medication. You dose someone with the correct amount of an appropriate opioid, and it will get rid of the pain. The same can't be said for non-narcotic analgesics, which all have a fraction of the effectiveness of even the weakest and least recreational opiates. There are other more obscure treatments, but they tend to also be sporadic in their effectiveness. Again, opiates have their own problems, and a broader appeal than benzos (although I'd argue that most people who develop serious, long term problems with ''opiate abuse'' are actually self medicating psychological symptoms), but they work, which is why they're the standard for treating pain.

In short, these drugs are preferred because they reliably do the job they're supposed to do just as much as because, in the case of opiates, they induce a euphoric high.
 
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You know what drug has the lowest NNT (Number Needed to Treat) for chronic pain? Pregabalin so saying ALL non-narcotic analgesics have a 'fraction of the effectiveness of the weakest opioids' is clearly and demonstrably false, some are even more effective. Treating chronic pain is quite different than treated a busted fibula of course though. I could give far more examples of demonstrably effective alternatives to controlled substances for different indications but I suspect it wouldn't matter anyway if you don't care about that and you're going just going to believe what you do because it fits the rationalization.

My point wasn't that benzos are the most recreational drug ever but that doctor's have good reason to be cautious with them and many who have been around a while are all too familiar with the fallout of prescribing them too cavalierly. Standard protocols don't always call for them to be used as a first-line treatment and much of the recent professional literature of late calls on doctors to try less problematic (but still demonstrably) effective alternatives first and if those fail, then consider benzos but a history if illicit use is always going to make doctors weary of prescribing controlled medications. It's interesting to me how on BL, SSRI's, bupirone, hydroxyzine, atomoxetine, etc. NEVER, EVER work but in real life, the people I come into contact with have experience that match the clinical efficacy of the drug much more closely.

Treatment protocols are pretty straightforward as well and when someone demonstrates a history of non-sanctioned use (such as pissing positive for morphine), of course their first line is going to be one a drug without the potential for abuse and this was an ER doc! He shouldn't be the one managing these problems anyway and was merely giving the OP something he felt could be beneficial and felt comfortable prescribing given the context. If a doctor finds out a patient uses morphine recreationally, would it be responsible to say, "here, have some xanax to add to that so we can make sure you stop breathing."

I have seen many, many people medicate anxiety with illicit use of opioids or benzos, alcohol, etc. and I don't personally believe this should disqualify them from being treated with benzodiazepines but you have to consider the context such as how a doctor will follow up (ER docs can't) and what other treatments they can make sure you're undergoing to get the anxiety under control.

Another thing I have learned reading BL for many, many years is that BLers look for a pill to treat everything. Addicts want the easy way out, they don't want to work for it or endure the discomfort of the type of non-pharmaceutical therapeutic interventions that have the best success at treating anxiety; they just want to find which band aid is the most effective at making sure they don't have to think about/deal with the problem. CBT and other techniques (especially when individualized to both the person and the problem) are hands down the best way to treat these problems but over the years I've seen hundreds of posts where people complained that their doctors wouldn't prescribe them benzodiazepines as first line, at all or any more but yet to see one that complains a they they didn't have access to a good psych professional for cognitive behavioral theraphy; they just want to be given some pills to chill them out and that's a big part of it for mant around here
 
You know what drug has the lowest NNT (Number Needed to Treat) for chronic pain? Pregabalin so saying ALL non-narcotic analgesics have a 'fraction of the effectiveness of the weakest opioids' is clearly and demonstrably false, some are even more effective. Treating chronic pain is quite different than treated a busted fibula of course though. I could give far more examples of demonstrably effective alternatives to controlled substances for different indications but I suspect it wouldn't matter anyway if you don't care about that and you're going just going to believe what you do because it fits the rationalization.

Pregabalin is also indicated for a specific type of pain, forms at least a moderate physical dependance and is, going off the big thread in Other Drugs, at least mildly ''recreational'' itself. Not to mention it comes with a host of side effects (, and many of these side effects aren't well understood, especially for a such a new drug, which I personally find worrying). There's also a lot of sketchiness in it's history as far as development, obtaining approval, marketing, off-label prescription etc. goes.

On the flip side, you have opiates, which relieve pain almost universally, have been used to do so since the dawn of civilization and as such are well understood, along with being well tolerated. If you're unable to work or sleep because of pain, which one would you want to leave the doctor's office with? There's plenty of time to look into long term, hopefully more sustainable and more permanent treatments (and it requires plenty of time), but to leave the person in pain and unable to function while they wait for something which has a small chance of maybe helping somewhat is nothing short of cruelty and negligence.

My point wasn't that benzos are the most recreational drug ever but that doctor's have good reason to be cautious with them and many who have been around a while are all too familiar with the fallout of prescribing them too cavalierly. Standard protocols don't always call for them to be used as a first-line treatment and much of the recent professional literature of late calls on doctors to try less problematic (but still demonstrably) effective alternatives first and if those fail, then consider benzos but a history if illicit use is always going to make doctors weary of prescribing controlled medications. It's interesting to me how on BL, SSRI's, bupirone, hydroxyzine, atomoxetine, etc. NEVER, EVER work but in real life, the people I come into contact with have experience that match the clinical efficacy of the drug much more closely.

Firstly, someone who's experiencing debilitating symptoms doesn't have time to cycle through SSRI's and assorted other meds on the off chance that they may provide some benefit which outweighs the side effects. People want benzos as the first line of treatment because benzos work immediately and reliably, providing minimal disruption to their life. Then while the benzos manage their anxiety, they have time to experiment with the more dubious, long term treatments. Doing it in the opposite order will only result in the complete disruption of the individuals life, as their functioning crumbles while they wait a month for X med to work, only to find out, whoops, it doesn't, let's try Y med, spend months going through this whole harrowing process while their symptoms get worse, then as likely as not, they end up on benzos at one stage or another anyway, or they get desperate and disillusioned enough to find a new doctor or bypass the medical system alltogether. This process is horrible enough in a country with decent healthcare, I'd hate to see what it's like in the US, where the majority of bluelighters come from.

As for the latter point, have you considered that if an individual found their anxiety adequately treated by other medication, they wouldn't be on bluelight talking about benzos in the first place? They'd be out enjoying their anxiety free, benzo free existence.

Treatment protocols are pretty straightforward as well and when someone demonstrates a history of non-sanctioned use (such as pissing positive for morphine), of course their first line is going to be one a drug without the potential for abuse and this was an ER doc! He shouldn't be the one managing these problems anyway and was merely giving the OP something he felt could be beneficial and felt comfortable prescribing given the context. If a doctor finds out a patient uses morphine recreationally, would it be responsible to say, "here, have some xanax to add to that so we can make sure you stop breathing."

If we're going to go into the specifics of the OP's case, then it's a bit more complicated than that. From the doctors point of view, it's easy, but not exactly reasonable or professional, to assume that the individual has morphine in their system because they're trying to get high. And to be fair, that is what it sounds like happened in this particular case, but there are plenty of other reasons someone can test positive for morphine - all it takes is a headache and a friend offering you some panadeine forte (or T3's as I think they're called in the States) and bam, you have morphine in your system.

I won't argue that it doesn't seems pretty cut and dry in the OP's case, going off what he's said, but I'm just pointing out that there's a broader spectrum to the issue at large. Not everyone who has opiates in their system is a filthy, drug seeking junkie trying to work the system, not everyone who goes through their benzo script early is trying to get some kind of ''high,'' and again, if these non-abusive medications worked nearly as well as the ''abusive'' ones, then people wouldn't be here on bluelight talking about their abusive counterparts, they'd be out enjoying life. I've seen more than one person find a treatment that works for their problems, or even a cure, and abandon this place to move on. Unfortunately is usually takes them years and a lot of time, money and suffering. The fact that someone is here (discussing these kind of drugs - the whole hullucinogen/MDMA/etc. situation is another issue) suggests that there's still something in need of treatment.

Another thing I have learned reading BL for many, many years is that BLers look for a pill to treat everything. Addicts want the easy way out, they don't want to work for it or endure the discomfort of the type of non-pharmaceutical therapeutic interventions that have the best success at treating anxiety; they just want to find which band aid is the most effective at making sure they don't have to think about/deal with the problem. CBT and other techniques (especially when individualized to both the person and the problem) are hands down the best way to treat these problems but over the years I've seen hundreds of posts where people complained that their doctors wouldn't prescribe them benzodiazepines as first line, at all or any more but yet to see one that complains a they they didn't have access to a good psych professional for cognitive behavioral theraphy; they just want to be given some pills to chill them out and that's a big part of it for mant around here

That's a load of nonsense. Firstly, you characterize the entire bluelight population as 'addicts,' which is unfair and untrue. Secondly, you suggest that they intentionally avoid seeking out non-pharmaceutical methods of treatment, when you have absolutely no idea that this is true (unless you've done an extensive survey, in which case I'd love to see it).

Bluelight is a forum for talking about drugs and how to reduce the harm from the consumption of those drugs. When someone asks a question about treating anxiety with benzos, I don't start rambling on about my daily meditation routine, or my weekly psychotherapy, because that isn't what they asked about and this isn't the place for that conversation (although I do try to make a point of recommending they seek out complementary modes of treatment if it seems relevant). There are section of bluelight where those conversations are more common (Dark Side - Sober Living - Healthy Living, etc), but you're not going to find that conversation somewhere like Basic Drug Discussion because it's blatantly off topic.
 
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This process is horrible enough in a country with decent healthcare, I'd hate to see what it's like in the US, where the majority of bluelighters come from.

Oh yes, the healthcare system in the USA is terrible, that's for sure. On the specific topic of benzodiazepines, though, it isn't really that difficult to obtain them from a doctor, at least not in my experience...when I lived in Texas from 2010/2011, for example, I went to a walk-in clinic complaining of anxiety and the doctor who saw me wrote me a prescription for Xanax after a ten minute conversation. That was my first experience with the drug, before then I didn't even know what a benzodiazepine was. Although my experience in that state indicated to me that doctors gave out drugs pretty freely, the doctors in the state I live in now are much more "stingy" with the drugs.

The Xanax they gave me was a low dose, 30 0.5 mg tablets IIRC, and when I went back after a month to get the prescription refilled, the nurse who saw me kind of guilt-tripped me about the addictive potential of the drug I felt, even though I had only went through 30 tablets in 30 days. I didn't bother getting it refilled after that...I hate it when people in the medical community treat me like that. (Not in regards to matters of potential addiction; those are certainly issues which should be discussed. It was more the manner in which I was told about that issue.)

I do agree with the general sentiment of what you're saying, though. Personally I think SSRIs are trash and I know very few people who've had good experiences with them. I can see where C2TL is coming from too, though...benzodiazepines are effective but even someone like me who's never been addicted to them can occasionally fall into using them as a "crutch". They definitely don't "cure" anxiety, and trying to find strategies of managing anxiety which don't involve drugs is definitely optimal I think.
 
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Well the Hydroxyzine did nothing for my anxiety, didnt feel any sedation even when taking 100mg at a time and ultimatley gave me weird dreams. but i wouldnt say it has no benefits for someone else, just not me. i did enjoy reading all the comments on here Bluelighters are great people. most of em' :p
 
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