• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

Mescaline in close proximity to other psychedelics?

Goddess Mode

Goddess Mode

Bluelighter
Joined
Apr 21, 2014
Messages
283
This is something I've been wondering about for a while.... I've often heard people say that the way mescaline builds tolerance is a little different to many other psychedelics. But I didn't really know what a possible reason for it could be until I read this:

http://www.ncbi.nlm.nih.gov/pubmed/1969270

Lysergic acid diethylamide (LSD) administration selectively downregulates serotonin2 receptors in rat brain. said:
A dosage regimen of lysergic acid diethylamide (LSD) that reliably produces behavioral tolerance in rats was evaluated for effects on neurotransmitter receptor binding in rat brain using a variety of radioligands selective for amine receptor subtypes. Daily administration of LSD [130 micrograms/kg (0.27 mumol/kg) intraperitoneally (IP)] for 5 days produced a decrease in serotonin2 (5-hydroxytryptamine2, 5-HT2) binding in cortex (measured 24 hours after the last drug administration) but did not affect binding to other receptor systems (5-HT1A, 5-HT1B, beta-adrenergic, alpha 1- or alpha 2-adrenergic, D2-dopaminergic) or to a recognition site for 5-HT uptake. The decrease was evident within 3 days of LSD administration but was not demonstrable after the first LSD dose. Following 5 days of LSD administration the decrease was still present 48 hours, but not 96 hours, after the last administration. The indole hallucinogen psilocybin [1.0 mg/kg (3.5 mumol/kg) for 8 days] also produced a significant decrease in 5HT2 binding, but neither the nonhallucinogenic analog bromo-LSD [1.3 mg/kg (2.4 mumol/kg) for 5 days] nor mescaline [10 mg/kg (40.3 mumol/kg) for 5 or 10 days] affected 5-HT2 binding. These observations suggest that LSD and other indole hallucinogens may act as 5-HT2 agonists at postsynaptic 5-HT2 receptors. Decreased 5-HT2 binding strikingly parallels the development and loss of behavioral tolerance seen with repeated LSD administration, but the decreased binding per se cannot explain the gamut of behavioral tolerance and cross-tolerance phenomena among the indole and phenylethylamine hallucinogens.
Click to expand...

Mescaline doesn't effect binding to 5-HT2A receptors. This is the same case as for DMT. That definitely seems like a potential factor, right?

What's interesting is that I've heard people say that you can take mescaline for days without tolerance, which fits with this and with how DMT works, but I've also heard people say that taking it before another psychedelic produces tolerance to that, but taking it after still allows for a full mescaline effect. That's the exact opposite of how I would expect DMT to work!

So, I'm curious... does anyone here have experience using mescaline in close proximity to other psychedelics, before or after? If so, what did you find in relation to tolerance? I'm not looking for "oh, anything that binds to 5-HT2A should produce cross-tolerance" answers here, I want real anecdotes!
 
Okay, i think i just kind of figured out the answer you might be needing.
Ultimately. Mescaline is a Phenethylamine, and LSD is a Tryptamine.
Now, i feel as if the tryptamine, is more like a Key, that the Phenethylamine is like a Switch.
The Phenethylamine Depletes more neurotransmitters than the Key. The Key just unlocks you minds triggers of perception allowing for an Altered state.
Mescaline is more in relation to MDMA than it is to LSD.
So i would Do the LSD First, and then the mescaline later. If that is what you are asking.
Do not expect a decrease in the Euphoric aspects of mescaline. But perhaps a decrease in visuals.
 
Are you saying that from personal experience? That's what I'm really looking for here. I intend to try both ways myself eventually, I just want to know what others' experiences have been!

I do appreciate the advice. :) But it doesn't quite answer what I'm looking for.... I'm wondering if you thought I was asking about LSD as well because of the study? Actually though I just happened to be reading about LSD when I came upon this. I was really just asking about mescaline, specifically, in close proximity to *any* other psychedelic; it could be a tryptamine, but it could equally be, like, 2C-E.

This is what I was thinking about.... I tend to trip about once a week. I would probably normally trip more often, but I just want to give my tolerance a chance to level out. Not that I feel the need to trip that often, I just often find myself thinking that it would be the perfect time to trip, but it hasn't always been long enough since my last journey to justify it. Something I like about DMT is that the same rules don't necessarily always apply to it. That is to say that I could trip on, say, mushrooms one day, and I wouldn't want to trip on DMT in the next couple of days out of fear that the trip would be sort of weakened due to tolerance. But because DMT doesn't produce tolerance, I could fearlessly do it in the other direction.... I would gladly do DMT one day and mushrooms the next if I felt like it while still expecting a full experience both times.

The one testimony I could find about using mescaline this way said that it would work in the other direction, that mushrooms after mescaline would have a diminished effect, but mescaline after mushrooms would give a full experience on both. I found that a little odd given this data about mescaline and 5-HT2A binding, but it at least sparked my interest. One anecdote is not really enough to base and educated opinion on though for when I test it myself, so I was really just wondering if anyone else had given this a shot as well.

Really, I'm trying to get an idea of if I can add mescaline to my list of "two trips a week" drugs, which currently only contains DMT.
 
Goddess Mode said:
Mescaline doesn't effect binding to 5-HT2A receptors. This is the same case as for DMT. That definitely seems like a potential factor, right?

What's interesting is that I've heard people say that you can take mescaline for days without tolerance, which fits with this and with how DMT works, but I've also heard people say that taking it before another psychedelic produces tolerance to that, but taking it after still allows for a full mescaline effect. That's the exact opposite of how I would expect DMT to work!

So, I'm curious... does anyone here have experience using mescaline in close proximity to other psychedelics, before or after? If so, what did you find in relation to tolerance? I'm not looking for "oh, anything that binds to 5-HT2A should produce cross-tolerance" answers here, I want real anecdotes!
Click to expand...

OK, you're saying DMT does or doesn't create tollerance the way LSD does?

sorry, but i have no anecdotal info on your querry though...
 
No worries. :) DMT doesn't create tolerance the way LSD does. There was a study that tested DMT's ability to effect 5-HT2A and 5-HT2C receptors; the latter was downregulated like normal, while the former was unchanged.
 
You must log in or register to reply here.
Top