Hans Meyer
Bluelighter
Self-testing of new Phenyethylamin substances of the NXXX-phenyehthylamin class
In the future I will use this thread to publish my work on new Research Chemicals that I have created and tested in self-tests. For now I will focus on the PEA-NDEPA (substituted Phenyethylamino-N,N-diethylpropanamides) line and the PEA-NBX (N-benzyl-substituted Phenylethylamines) line of chemicals.I might add different lines of chemicals later though.
The Idea of focusing on PEA-NDEPA Chemicals came from reading the German publication:
Schulze-Alexandru, Meike; Kovar, Karl-Artur; Vedani, Angelo (Institute of Pharmacy, University of Tubingen, 72076 Tubingen, Germany): „Quasi-atomistic Receptor Surrogates for the 5-HT2A Receptor: A 3D-QSAR Study on Hallucinogenic Substances“, Quant. Struct.-Act. Relat.1999, 18(6), 548-560, Wiley-VCH Verlag GmbH.
While not fully understanding its contents, the last sentence struck me:
„The most promising candidate compound is a molecule which represents a hybrid structure between LSD and phenylalkylamines such as DOI*. The binding affinity of this compound towards the 5-HT2A-receptor is predicted to be K=3.2 nM, close to the experimental binding affinity of LSD (K=2.5 nM). Some of these compounds have been synthesized in the meantime, allowing for a critical evaluation of our model.”
*The Authors are referring to DOI-NDEPA. There has been no more Literature on this topic since then.
The first publication on the Topic of PEA-NBX was AFAIK:
Molecular Pharmacology Fast Forward. Published on September 25, 2006 as doi:10.1124 / mol.106.0287; MOL #28720:“Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with super-potent N-benzyl phenethylamine agonists”, Michael R. Braden, Jason C. Parrish, John C. Naylor, David E. Nichols, Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47907.
(If you are interested in either of the articles plz pm me with an Email and I will gladly provide a copy.)
I published my own findings on the matter on the 10.5.2014 in a PDF. It is accessible here: Table of SV_v2.0.1.pdf (Listings of self-tests on new Rcs) (in German Language). Table of SV_v2.0.1.pdf (Listings of self-tests on new Rcs, experimental part in English)
Because of difficulties in finding this publication I decided to republish the Results. Special Thanks to „perpetuaklawn“ for the hint to publish every substancereport in a seperate posting. Format of date „yymmdd“.
*mod edit: Here is a link to the document (in German) detailing the compounds somewhat more: New RCs Possible
Appeal to Producers and Sellers of Research Chemicals, Spice, Bathsalts...
Have in mind that your success is based on war on drugs and on that alone! You as producer and seller bear the responsibility for customer service and satisfaction! Don´t sell substances not tested by yourself! Give hints and warnings, such as: „Unfit for human consumption! Likely to cause severe harm if accidentally swallowed in doses larger than ….mg. In that case it is highly recommended to seek medical advice!“
Summary of the products characteristics
PEA-NDEPA-salts are hygroskopic, crystallise only very slowly and, hence, are to be cleaned laboriously (see pictures). Nevertheless, they show, dependent on substance, effect-increases and qualitative effect changes compared with her accompanying PEA. Here changes in PEA- (e.g. -CH3 to the amine), as well as in the NDEPA-part (nearer to the LSD-structur) could prove interesting new substances (it seems that above all the amphetamine analogous show the stronger effects). PEA-NBX mostly have greater effectiveness and qualitatively other effects, than her accompanying PEA. For strong effect a group with a free Electron pair in the N-Benzyl seems necessary at ortho position (e.g. -OH, -OCH3): the stronger the Electron donating power, the more efficiently, but possibly also more toxically works the substance: e.g. -OC2H5 > -OCH3. Increasing order of +I-inductiv effect https://en.wikipedia.org/wiki/Inductive_effect and increasing lipophilicity https://en.wikipedia.org/wiki/Lipophilic_efficiency may increase potency. This working hypothesis offers a large amount of new RC to be tested: e.g. replacement of ortho-O-CH3 by -O-C2H5, -O-allyl, -O-iso-Propyl..., -SH, -S-alkyl, -NH2, -NH-alkyl, -N(alkyl)2, etc.... but also Heterocycles, e.g. 2-pyridyl-methyl-, 2-thienyl-methyl-... etc. could be effective, as the example 2C-D-N3TM points out. The PEA-part of the PEA-NBX also may be changed. The most effective seems to be 2,5-Dimethoxy-4-chlor-PEA-NBX, but also the 3,4,5-Trialkyl-PEA-NBX (e.g. with Mescaline, Escaline...etc.) show increased potential compared to her mother-PEA.
Identification of the substance
There are no physical tools available to me, to ensure the given structures of the substances, e.g. IR, UV, NMR, GC-MS etc. What I can say, however, is that the given chemical structures fullfill as well all expected properties observed during the well established synthesis procedures itself as all expected properties during the process of isolation of the final products. And only classical, well ensured organic synthetic strategies were used. Last, but not least, observed mind-altering effects demonstrate the integrity of the "chain of evidence".
My reasons for finding out and publishing new research chemicals
Humans need an intoxication or drunkenness or ecstasy from time to time. And they should be allowed to decide by their owne, wich one and with wich means. Not the drug produces dependence or addiction, one´s character structure leads to excessive use, suggesting problem-solving of distressing feelings. Dependence should be seen as it is: not produced by a drug, but rather as a psycho-social problem.
War on drugs will continue. Eugene Jarecki carfully researches show the political reasons for this war and failure for a policy that is urgently in need of rethinking; a political war, followed by discrimination of and war on the BLACK
(Eugene Jarecki and the campaign to end America's war on drugs: http://www.theguardian.com/society/2013/mar/30/eugene-jarecki-war-on-drugs).
A big industry of suppression and repression has taken on a life of its own and can hardly be stopped. Discrimination and Illegalisation of most of the outlawed hallucinogens (e.g.Mescaline, MDMA, LSD, Psylocybin...) leads scandalously to discrimination and illegalisation of a very helpfull psychotherapy: the psycholytic therapy. However, I hope the wave of research chemicals will help to build up more pressure in discussing and legislating for more liberalisation and more intelligent use of drugs.
My set and setting
Slightly depressed; trips with small amounts, mostly during nordic walking in nature or listening music at home, often helps; also small amounts (3...6µg!) of e.g. 2C-C-NB25diOMe in the evening. Expect (at higher doses) Mescaline-/LSD-like response. All results and statements are self-evident valid to me only, as the only test person. Each clientis an individual and will respond uniquely in accordance with „Set“ and „Setting“. I didn´t give any substanc to other people and will not do so in future. I usually used small amounts only; higher doses I hardly can tolerate any more.
Uncertainties of doses:
Number of digits are not significant but only contributed to computation. ±(3...30%) uncertainties are – dose dependent – realistic. 3% can be assigned roughly to the higher doses and 30% to the very low ones. Mostly it ranges between 10 and 20%.
Abbreviations
s.l.: sublingual for xx minutes;
o.e.s.: oral empty stomach;
h: hour; ´: minute
na: not avaliable;
GERMAN ORIGINAL (can only be seen, if SCRIPTS are allowed):
Thank You borega for revision of this English text
In the future I will use this thread to publish my work on new Research Chemicals that I have created and tested in self-tests. For now I will focus on the PEA-NDEPA (substituted Phenyethylamino-N,N-diethylpropanamides) line and the PEA-NBX (N-benzyl-substituted Phenylethylamines) line of chemicals.I might add different lines of chemicals later though.
The Idea of focusing on PEA-NDEPA Chemicals came from reading the German publication:
Schulze-Alexandru, Meike; Kovar, Karl-Artur; Vedani, Angelo (Institute of Pharmacy, University of Tubingen, 72076 Tubingen, Germany): „Quasi-atomistic Receptor Surrogates for the 5-HT2A Receptor: A 3D-QSAR Study on Hallucinogenic Substances“, Quant. Struct.-Act. Relat.1999, 18(6), 548-560, Wiley-VCH Verlag GmbH.
While not fully understanding its contents, the last sentence struck me:
„The most promising candidate compound is a molecule which represents a hybrid structure between LSD and phenylalkylamines such as DOI*. The binding affinity of this compound towards the 5-HT2A-receptor is predicted to be K=3.2 nM, close to the experimental binding affinity of LSD (K=2.5 nM). Some of these compounds have been synthesized in the meantime, allowing for a critical evaluation of our model.”
*The Authors are referring to DOI-NDEPA. There has been no more Literature on this topic since then.
The first publication on the Topic of PEA-NBX was AFAIK:
Molecular Pharmacology Fast Forward. Published on September 25, 2006 as doi:10.1124 / mol.106.0287; MOL #28720:“Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with super-potent N-benzyl phenethylamine agonists”, Michael R. Braden, Jason C. Parrish, John C. Naylor, David E. Nichols, Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47907.
(If you are interested in either of the articles plz pm me with an Email and I will gladly provide a copy.)
I published my own findings on the matter on the 10.5.2014 in a PDF. It is accessible here: Table of SV_v2.0.1.pdf (Listings of self-tests on new Rcs) (in German Language). Table of SV_v2.0.1.pdf (Listings of self-tests on new Rcs, experimental part in English)
Because of difficulties in finding this publication I decided to republish the Results. Special Thanks to „perpetuaklawn“ for the hint to publish every substancereport in a seperate posting. Format of date „yymmdd“.
*mod edit: Here is a link to the document (in German) detailing the compounds somewhat more: New RCs Possible
Appeal to Producers and Sellers of Research Chemicals, Spice, Bathsalts...
Have in mind that your success is based on war on drugs and on that alone! You as producer and seller bear the responsibility for customer service and satisfaction! Don´t sell substances not tested by yourself! Give hints and warnings, such as: „Unfit for human consumption! Likely to cause severe harm if accidentally swallowed in doses larger than ….mg. In that case it is highly recommended to seek medical advice!“
Summary of the products characteristics
PEA-NDEPA-salts are hygroskopic, crystallise only very slowly and, hence, are to be cleaned laboriously (see pictures). Nevertheless, they show, dependent on substance, effect-increases and qualitative effect changes compared with her accompanying PEA. Here changes in PEA- (e.g. -CH3 to the amine), as well as in the NDEPA-part (nearer to the LSD-structur) could prove interesting new substances (it seems that above all the amphetamine analogous show the stronger effects). PEA-NBX mostly have greater effectiveness and qualitatively other effects, than her accompanying PEA. For strong effect a group with a free Electron pair in the N-Benzyl seems necessary at ortho position (e.g. -OH, -OCH3): the stronger the Electron donating power, the more efficiently, but possibly also more toxically works the substance: e.g. -OC2H5 > -OCH3. Increasing order of +I-inductiv effect https://en.wikipedia.org/wiki/Inductive_effect and increasing lipophilicity https://en.wikipedia.org/wiki/Lipophilic_efficiency may increase potency. This working hypothesis offers a large amount of new RC to be tested: e.g. replacement of ortho-O-CH3 by -O-C2H5, -O-allyl, -O-iso-Propyl..., -SH, -S-alkyl, -NH2, -NH-alkyl, -N(alkyl)2, etc.... but also Heterocycles, e.g. 2-pyridyl-methyl-, 2-thienyl-methyl-... etc. could be effective, as the example 2C-D-N3TM points out. The PEA-part of the PEA-NBX also may be changed. The most effective seems to be 2,5-Dimethoxy-4-chlor-PEA-NBX, but also the 3,4,5-Trialkyl-PEA-NBX (e.g. with Mescaline, Escaline...etc.) show increased potential compared to her mother-PEA.
Identification of the substance
There are no physical tools available to me, to ensure the given structures of the substances, e.g. IR, UV, NMR, GC-MS etc. What I can say, however, is that the given chemical structures fullfill as well all expected properties observed during the well established synthesis procedures itself as all expected properties during the process of isolation of the final products. And only classical, well ensured organic synthetic strategies were used. Last, but not least, observed mind-altering effects demonstrate the integrity of the "chain of evidence".
My reasons for finding out and publishing new research chemicals
Humans need an intoxication or drunkenness or ecstasy from time to time. And they should be allowed to decide by their owne, wich one and with wich means. Not the drug produces dependence or addiction, one´s character structure leads to excessive use, suggesting problem-solving of distressing feelings. Dependence should be seen as it is: not produced by a drug, but rather as a psycho-social problem.
War on drugs will continue. Eugene Jarecki carfully researches show the political reasons for this war and failure for a policy that is urgently in need of rethinking; a political war, followed by discrimination of and war on the BLACK
(Eugene Jarecki and the campaign to end America's war on drugs: http://www.theguardian.com/society/2013/mar/30/eugene-jarecki-war-on-drugs).
A big industry of suppression and repression has taken on a life of its own and can hardly be stopped. Discrimination and Illegalisation of most of the outlawed hallucinogens (e.g.Mescaline, MDMA, LSD, Psylocybin...) leads scandalously to discrimination and illegalisation of a very helpfull psychotherapy: the psycholytic therapy. However, I hope the wave of research chemicals will help to build up more pressure in discussing and legislating for more liberalisation and more intelligent use of drugs.
My set and setting
Slightly depressed; trips with small amounts, mostly during nordic walking in nature or listening music at home, often helps; also small amounts (3...6µg!) of e.g. 2C-C-NB25diOMe in the evening. Expect (at higher doses) Mescaline-/LSD-like response. All results and statements are self-evident valid to me only, as the only test person. Each clientis an individual and will respond uniquely in accordance with „Set“ and „Setting“. I didn´t give any substanc to other people and will not do so in future. I usually used small amounts only; higher doses I hardly can tolerate any more.
Uncertainties of doses:
Number of digits are not significant but only contributed to computation. ±(3...30%) uncertainties are – dose dependent – realistic. 3% can be assigned roughly to the higher doses and 30% to the very low ones. Mostly it ranges between 10 and 20%.
Abbreviations
s.l.: sublingual for xx minutes;
o.e.s.: oral empty stomach;
h: hour; ´: minute
na: not avaliable;
GERMAN ORIGINAL (can only be seen, if SCRIPTS are allowed):
NSFW:
Thank You borega for revision of this English text
Last edited:
