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D-Deprenyl

my bad, if I was incorrect on that. My understanding is that anal tissue goes right to the blood stream, in a manner similar enough to nasal / sublingual MOA. Am hoping someone can clarify. The way I understood it was that the majority of the maoB enzymes were GI enzymes and, by bypassing the gut, you could make bpea active w/o using secondary products to inhibit maoB. I cannot say I know 1st-hand if that's the case, have never plugged anything before lol, there's just always been better ways for any drug IMO.
 
Plugging won't bypass MAO very well, if at all. Blood still circulates through the intestinal tissue, liver etc which have active MAO enzymes, meaning you gain maybe 30 seconds of extra time before it gets eaten. It's not like the compound is all delivered from rectum (or sinuses) to brain directly.

Same with injection... you'll still have half life issues. DMT is the canonical example.
 
sekio said:
Plugging won't bypass MAO very well, if at all. Blood still circulates through the intestinal tissue, liver etc which have active MAO enzymes, meaning you gain maybe 30 seconds of extra time before it gets eaten. It's not like the compound is all delivered from rectum (or sinuses) to brain directly.

Same with injection... you'll still have half life issues. DMT is the canonical example.
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I found that informative til the last sentences; IV'd bpea is very, very equipotent to true amph. 30mg is really the most comfortable you can shoot (harm reduction note: it has to be a BIG shot w/ lots of water, cuz the ph of bpea sucks, so if you wanna bang 30mg you need to use an entire rig. If you were looking to do to 50mg+ shots, unsure how it'd even be possible, unless your rigs were unlike any i'd ever seen..
 
bmxxx said:
my bad, if I was incorrect on that. My understanding is that anal tissue goes right to the blood stream, in a manner similar enough to nasal / sublingual MOA. Am hoping someone can clarify. The way I understood it was that the majority of the maoB enzymes were GI enzymes and, by bypassing the gut, you could make bpea active w/o using secondary products to inhibit maoB. I cannot say I know 1st-hand if that's the case, have never plugged anything before lol, there's just always been better ways for any drug IMO.
Click to expand...

Okay, I didn't think so. I have never injected anything, I never wanted to cross that line, so for me plugging is one of my favorite ROAs and I have a lot of experience (with psychedelics mostly where it is fantastic because it virtually eliminates nausea and greatly reduces bodyload and of course dosage). I was going to be very surprised if plugging bypasses MAO since I have used so many psychedelics that way and the effect wasn't anything like combining them with an MAOI.
 
interesting, re plugging psychedelics, i usually would just 'attack dose' them (I like to go hard when tripping lol), but bodyload is always problematic for me. Does that apply to lsd/mushrooms? next time I'm lucky enough to see some of that shit around, perhaps I'll break my plugging-virginity LOL
(edit: FWIW, I couldn't imagine someone plugging bpea; if you smell that shit, or feel its pH, I can only imagine that, after plugging, you'd be writhing in pain feeling like your ass were burning off!!)
 
I've plugged some chemicals that burn, it burns orders of magnitude less than snorting does though. Plugging LSD from what I've heard doesn't really change from plugging, because the oral BA of LSD is very high. And I can't imagine plugging mushrooms, not sure how you could effectively do that. I've plugged synthetic 4-HO-DMT though (which is significantly different from mushrooms - not just plugged). It really works great for the 2C-Xs, the tryptamines, amphetamines, opiates... most things. It makes the come-up faster, the tail end return to baseline faster, and doesn't reduce the peak time very much so it's not that much shorter in duration than oral (maybe 80%). Bodyload is dramatically reduced and nausea is rare. I have never IMed but I have heard esteemed members compare it most closely with IM administrration in timeframe and smoothness.
 
sadly, have never tripped on a phenethylamine and, after reading that, realize how silly the idea of plugging mushrooms would be (unless one had pharma grade psilocin); furthermore, lsd hardly ever gave me bodyload, it was always mushies that gave uncomfortable come-ups the 1st hr or so... I'd erase that post but since someone's responded already, guess I'll just leave it :\
 
Perfect segue into my Greenlight question about the effectiveness of plugging either isomer of Selegiline, will it improve bioavailability or burn me a new lower intestine? It is my preferred route for d-amp. Thanks!
 
Heh, there would be no real advantage to this route of administration for an irreversible enzyme inhibitor. Though selegiline's oral bioavailability is low, you can just adjust the dosage upward and/or dose on consecutive days. Taking it sublingually on a full stomach of fatty food helps (though it's not the best tasting thing on earth).

ebola
 
bmxxx said:
sadly, have never tripped on a phenethylamine and, after reading that, realize how silly the idea of plugging mushrooms would be (unless one had pharma grade psilocin); furthermore, lsd hardly ever gave me bodyload, it was always mushies that gave uncomfortable come-ups the 1st hr or so... I'd erase that post but since someone's responded already, guess I'll just leave it :\
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I plugged synthetic 4-HO-DMT before, it worked fantastically but you certainly wouldn't catch me plugging mushrooms. :)
 
Sorry to rehash, but this guy my cousin's online boyfriend spoke to on Chatroulette was saying he was prescribed eldepryl for depression and was wondering if, when taken sublingually, the remaining eldep not absorbed by the tongue was absorbed in the GI tract, and that if taken sublingually, the active levo amp and levo methamp metabolites are largely not created when bypassing GI absorption. He apologizes for his limited understanding as he also has comorbid ADHD.
 
taken sublingually, the active levo amp and levo methamp metabolites are largely not created when bypassing GI absorption.
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This is not true: the compound will eventually be circulated to your liver, but just after greater delay than with oral administration. . .not that these metabolites will ever be formed in behaviorally relevant amounts.

ebola
 
Thanks Ebola. Kinda what I was hoping / assuming. Assuming careful titration, then, and a BP/HR monitor, how safe is using Selegiline with contraindicated dexamph? Selegiline dose would be 5mg, d amp starting at 2.5mg.
 
ebola? said:
It's not safe: you should expect unpredictable, possibly physiologically dangerous potentiation.

ebola
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Why would that be? I know maoB is a large way for clearing d-amp, but even still how could only 2.5mg be dangerous? A 2.5mg load taken IV would have it's effect fully realized before maoB started clearing it, no? If that's the case (and 2.5mg d-amp IV isn't significantly dangerous), then how does fully inhibiting maoB work any differently?
 
It's not dangerous at all. That is the very reason for the creation of SELECTIVE irreversible MAO-Bi, as indeed irreversible MAO-A inhibition has complications in regards to tyramine (and related) metabolism (the infamous cheese effect) within potentials for hypertensive crisis.

Moclobemide rectifies that as to being a selective MAO-Ai that is reversible, selective, and efficacious, without adverse effect potential as seen with other classic MAO-Ai. Several herbs as well have this effect, but Pharma and synthetics tend to be playing catch up with nature. ;)http://en.wikipedia.org/wiki/Moclobemide

Note, the alpha position methylation on amphetamine upon the endogenous trace amine phenethylamine allows for protection from MAO-B metabolism and as such imparts a far more pronounced effect. MAO-Bi will impart some mood uplift generally in and of itself as it will enable endogenous (or exogenously administered) PEA to maintain greater activity.

Deprenyl (and other MAO-Bi agents) will via actions upon the dopaminergic system potentiate dopaminergic agents to some degree, so that should be accounted for within those who will use such concurrently. KISS version: If you administer selegiline/deprenyl or other MAO-Bi agent (ie., rasagiline) consider to use a somewhat reduced amount of any concurrently used dopaminergic agent.

Notably, amphetamine in and of itself has some MAOi properties.
 
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Thanks for the input, guys (non gender specific "guys" btw).
The last two posts echo sentiments expressed elsewhere online.
i.e. Careful and cautious titration of the amp. I only ever use pharma d-amp, so titration is somewhat easier than if we were talking illicit amps / smokable salts.

After two days on l-deprenyl, I feel like my mood is better and my energy and concentration have tapered off later in the day than they usually would. The other thing I have noticed is that my quality of sleep over the last two nights has been greatly improved.

Since 2009, I have smoked about 2g of cannabis / tobacco mix each day, mostly at night for sedative and calmative purposes. It also suppresses nearly all my dreams (95% of which were nightmares) and is the only thing besides clonazepam to stop my bruxism. The last few nights, I've had a deeper, more restful sleep, while at the same time having pleasant, even meaningful dreams. My partner said that she roused me several times after I fell asleep to see if I wanted a bong, and each time except the last I declined. The last time, about 1am, she offered me a bong, I had one instead of my usual two and went straight back to Dreamland :)

Selegiline, if nothing else, has had an immediate effect on my emotional lability and my quality of sleep.

Sorry for the above rant and also my poor comprehension, but I figure from what's been said, and I am probably wrong about this, that it would be most efficacious to have my l-deprenyl sublingually and blast my d-amp up the choccy starfish?

I know a heart rate monitor and BP monitor are both needed to safely monitor the interactions, I know there is very real potential for danger and I also know that if efficacious, this combo could change my life completely.

Barring the TGA approving Desoxyn, the only remaining treatment I've eschewed is self medication with illicit meth. I've managed to steer clear of non-pharmaceutical drugs until now, and would ideally like to avoid the complications of doing so.
 
you use the word 'treatment', but then you're talking about plugging d-amp? are you aiming for therapeutic usage or to get high? Not that there's anything wrong w/ either, but using amph drugs for therapeutic/lifestyle is much better achieved by oral consumption IMO.
 
Therapeutic use for sure. As somebody who doesn't wilfully consume animal products, I find it hard to reconcile my personal moral imperative to consider all other sentient beings with my need for pharmaceutical assistance in dealing with my depression and ADHD, as the d-amp I get contains lactose. As such, I am honestly not comfortable with orally consuming something that contains even a trace amount of milk, especially if I am holding it under my tongue for 10 to 15 minutes. I find the rectal bioavailability to be far superior to oral or sublingual ROA, with only slight decrease in duration. My mental health is such that once I am up n rolling on 10 or 15mg d-amp in the morning, I usually don't need much more in the arvo. Especially drinking a tall glass of water with two Ural sachets stirred through, I find that this increases duration / potentiates the amp noticeably. It may seem hypocritical to plug something I will not eat, and I am sure it seems weird to most that I am more "comfortable" shoving a syringe up ye olde poopin hole, but it is the best route for me. IM and IV are out owing to the makeup of the tablets, oh, and cause even more ironically, I am scared of needles :) Like, almost phobic. Also, I have weaned off coffee almost entirely but rectal ROA allowed me a culpa when I was on d-amp, and I know sublingual ROA would allow the same essentially, but the old "up the bum, no harm done" methodology appealed to me, and I considered it carefully before trying it :) That's meant to say "allowed me a cuppa", not mea culpa hehe, too hard to go back on this device. Thanks for the advice Bmxxx!
 
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