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D-Deprenyl

I'd be looking at d-dep over l-dep as an adjunct to my dex for depression and prefrontal cortex deficit. Anybody got any links to literature concerning likelihood of dependence on d-dep? I ask because I have a predisposition to substance dependence. 5 years of smashing bongs from sunrise to sunset and in between, to be precise. (Not the cause of my longstanding depression, incidentally). Have been self medicating with dex for 18 months. Avoiding meth due to my penchant for reward seeking behavior :)
 
Hi Ebola! It is more an informed guess than anything. Inability to do more than one thing at a time, extreme restlessness in the absence of external physical stimuli, marked impulsivity, inability to regulate emotional responses, frustration when encountering any difficulty in learning or interpersonal communication. "Ring of Fire" ADHD is as close a description to my personality as I have ever seen. A couple of years ago I would have laughed at those ADHD generalizations but aside from Borderline Personality Disorder, nothing has come close to explaining neither my external behavior nor my internal anguish and tumult. When I am on dex, it feels like I am in the eye of a cyclone. Aware of all the peripheral noise and action, but easily able to discriminate between useful and wasteful ways to spend my time. Sans dex, I literally AM the cyclone. Dex to me feels like a more calming diazepam, with added clarity. Thanks for asking :)
 
isnt deprenyl generic name for selegiline ? from what i have seen it always says Deprenyl (Selegiline), how can there be L and D Deprenyl ? is there D and L selegeline ?
 
it's not teh generic name, it's the chem name; selegeline is the branding, and deprenyl (the l- and d- isomers) are the 'proper' names.
(edit: selegeline is only the branding for l-deprenyl, AFAIK nobody has ever commercially manufactured the d- iso for commercialization. Could be wrong but when I wanted to get this in the recent-past I found d-deprenyl to be all but absent commercially, w/ the l- iso very available [and stupidly expensive... perhaps costly synth, or just too little supply right now?])
 
Spot on, I have only seen d dep available on the backstreets of the net and even then it is advertised as being for animal consumption only. Here, Selegiline is sold as Selgene, a generic trademark.
 
bmxxx wtf you talking about? i often see various brand names like Jumex (selegeline) and deprenyl (selegeline) and so on there are several. clearly the chemical is mentioned as selegiline and its not a brand as you say.

and btw selegiline is so subtly worthless, i dunno how it can be advertised and sold for parkinson when its so weak. i can assure you, a child would take 10mg selegiline and might feel a bit hyper for few hours and nothing of memorization of the event at all. basically, sugar does same job!
 
I could say 'wtf are you talking about' right back, but, because i remember your handle as someone who's in the know, i won't... but l- and d- deprenyl are the actual names, selegeline is product name - check wiki if you doubt me. And re it being worthless, do you know that or just assume it? cuz honestly selegeline (l- isomer) and methylphenidate are the 2 'lifestyle' products that I think i need to be one but just haven't tried yet.. most ppl's thoughts on selegeline are very positive, fwiw.
[edit: i never meant to imply selegeline was the only branded deprenyl product, my bad if my post implied that, but doubt it did]
 
The generic name (BAN/INN/USAN) is not Deprenyl, that's a brand name. The INN/BAN/USAN is selegiline (Not to be confused with Selgene, another trade name)

ref.
 
gah my bad then... but if that's so, then why is it commonly referred to as l- and d- deprenyl, w/ "l-deprenyl" being synonymous w/ 'selegeline'?
edit: am very, very sorry, i didn't understand it(wiki) properly, it read "Selegiline (Anipryl, L-deprenyl, Eldepryl, Emsam, Zelapar) is"... am still kind of confused, at least too confused to update the wiki on it, cuz it still reads (to me) awkwardly, like 'selegeline' is a brand name for l-isomer of deprenyl... i'm no chemistry person by a long shot so surely am just confusing myself here :\
 
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Why do people refer to acetaminophen as Tylenol, acetylsalicylic acid as Aspirin, diamorphine as Heroin, tissues as Kleenex, or plastic adhesive bandages as Band-Aids? Brand identity, man. It's become a generic trademark. Deprenyl is easier to spell than selegiline, too. Fewer vowels and syllables.

Deprenyl is trademarked by Sanofi-Aventis, I think. I believey Deprenyl is a generic term for the racemate as it's almost always specified as "L-deprenyl". Selegiline is specifically the L-form, it does not have stereochemistry mentioned, usually.
 
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so you mean the name 'deprenyl' is not a chemical name, but a chosen/patented name by sanofi? google isn't showing this patent, i may not be looking hard enough tho
[edit: more googling, still cannot find a patent on 'deprenyl', tho obviously many patents on proprietary deprenyl formulations ala 'ensam' etc]
 
It's not a patent, it's a trademark. Patents are for drugs and the uses of drugs. Trademarks are for the branding. In China Sanofi-Aventis holds the rights. In the US and many other countries, it has expired though.

USPTO said:
Word Mark DEPRENYL E
Goods and Services (ABANDONED) IC 005. US 018. G & S: PHARMACEUTICAL PREPARATIONS, NAMELY, AN ANTI-PARKINSON DRUG
Mark Drawing Code (1) TYPED DRAWING
Serial Number 73829462
Filing Date October 5, 1989
Current Basis 44D
Original Filing Basis 44D
Owner (APPLICANT) DEPRENYL RESEARCH LIMITED CORPORATION CANADA 378 RONCESVALLES AVENUE TORONTO, ONTARIO CANADA M6R 2M7
Attorney of Record JAMES M. SLATTERY
Priority Date July 27, 1989
Type of Mark TRADEMARK
Register PRINCIPAL
Live/Dead Indicator DEAD
Abandonment Date October 25, 1990
Click to expand...
 
sekio said:
Why do people refer to acetaminophen as Tylenol, acetylsalicylic acid as Aspirin, diamorphine as Heroin, tissues as Kleenex, or plastic adhesive bandages as Band-Aids? Brand identity, man. It's become a generic trademark. Deprenyl is easier to spell than selegiline, too. Fewer vowels and syllables.

Deprenyl is trademarked by Sanofi-Aventis, I think. I believey Deprenyl is a generic term for the racemate as it's almost always specified as "L-deprenyl". Selegiline is specifically the L-form, it does not have stereochemistry mentioned, usually.
Click to expand...


this explained it, thanks sekio, you know almost as much as i do apparently ;)

was wondering the d-form was never released commercially? i saw someone say it wasnt but im doing double check here. i wonder why it wasnt released to the public if it didnt??


yes bmxxx, i have done selegiline and its really subtle, very weak stimulant. when i bump the doses, it mostly shows side effects so i keep at in the suggested 5mg dose. but its so irritatingly subtle, you just wanna break 5 pills and snort or something cuz it has potential, but its just not there as it should be. hence curious of this d-form....

i thought adderall had all the amphetamine salts at first, then i read it had mixed salts of 80% l-form of amphetamine. but when i did amphetamines it had all the annoyances and side effects of adderall EXCEPT it gave me actual euphoria. adderall on the other hand, i used to mega dose on it btw, would STILL NOT GIVE ME A HIGH. so yeah, something to do with l-isomers being impotent.
 
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^ but it cannot be abused, whats the reason behind this? i tried big doses, snorted it too, no euphoria like speed would give me. i dont fucking get it
 
It is an enzyme inhibitor, so its activity won't scale smoothly upwards with dose, nor is it likely to have strong effects at any dose. Rapid methods of administration are pointless.

ebola
 
ebola, you had to tell me much sooner before i overdosed hard on that crap. to make things worse i also pushed it with redbulls which put me into some kind of seizure state lol
 
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