Natural resistance to the effects of opiates?

[Newbie McNewbersen]

Hello,

Let's say that someone who does not regularly use any substances (other than alcohol) and who had not used any substance in a few years, decided to take 360mg of codeine. Let's say that this person felt very little in the way of pleasant or enjoyable effects and basically only felt a little light headed and a little sedated.

Would this mean that this person is not able to enjoy pleasant effects from opiates for some reason? If this person were so inclined, would it be worthwhile for them to try a different opiate in the hopes of experiencing a different effect?

Thank you.

 

[jeng1128]

Hello,

Let's say that someone who does not regularly use any substances (other than alcohol) and who had not used any substance in a few years, decided to take 360mg of codeine. Let's say that this person felt very little in the way of pleasant or enjoyable effects and basically only felt a little light headed and a little sedated.

Would this mean that this person is not able to enjoy pleasant effects from opiates for some reason? If this person were so inclined, would it be worthwhile for them to try a different opiate and perhaps experience a different effect?

Thank you.

I'm honestly not trying to be a bitch but just say I. They hate when you use SWIM or someone I know. But to answer your ? If you've or you're friend or whomever has NEVER done opiates no one has a "natural tolerance" to opiates. Codine is extreamlly weak, I started in hydrocodone(not that's what Im telling you to do) not to mention all the ACAP you're putting in you're system. I've never heard of someone having a "natural" tolerance to opiates, That would really suck if you got really hurt or needed opiates. I've heard of people being allergic to opiates, and at the beginning everyone feels nauseous. But a natural tolerance No...I could be wrong and I'm sure someone will correct me if I am but I've personally never heard of it.

 

[jeng1128]

Oh and Welcome to Bluelight!:D

 

[wayab]

if you do decide to try another opiate it's good to start with a starter dose. 360mg is not a starter dose for codeine as weak as it may be.
do not assume that you are naturally tolerant to opiates.

 

[Newbie McNewbersen]

Thanks, sorry about the pharsing faux pas.

There were no other substances in the codeine, is was just codeine and nothing else.

I understand the as far as opiates go, codeine is at the bottom of the ladder, but I was under the impression that 360 mg should have been a large enough dose to get something out of it.

 

[wayab]

well it sounded that you did get something, just not what you expected. i can get pretty high with "just" 200mg but some people won't feel 360mg like yourself. some people have less of the enzymes needed to convert codeine to morphine in the body and you may be one of those people.

 

[jeng1128]

Everyones different. I've got to check the conversion chart, but there could be many factors why you didn't feel it like you thought you would. Maybe you were expecting too much? I've never even tried codeine except for maybe when I was a lot younger when I had a cough or something but I've never used it to get high. I actually just got 20 Tylenol 3's for a wisdom tooth being pulled(I didn't bother telling them I was a heavy opiate user because sometimes they won't give you anything at all.) I took them all(dumb of me because of the Tylenol but that tooth really hurt) and that'd be 600 mgs of codeine, didn't even get pain relief but like I said I've been using opiates(not at the time being) but I've used heavy for a long time so I'm expecting some huge feeling which isn't going to happen from codeine for me. But if you're not allergic to it, I'm 99.9% sure that if you shot even 5 bags you wouldn't od, or feel nothing because you have some built in tolerance.

 

[crohnspatient]

Well, since different opioids use a differing mechanism in the "lock and key" design, he could lack a number of receptors for said derivative. However, a lack of a "high" doesn't mean that it still cannot have the undesired effects on one's body. I for one would be very careful.

 

[Reb420]

I have also noticed this. I only have 3 opiate experiences. One time I ingested 150 mg codeine and felt a euphoric buzz for about 30 minutes and then nothing.
Another time I took 25 mg of hydrocodone and felt nothing at all. I waited 2 hours for it to kick in... and nothing.. But after that I took some amphetamines and I noticed that my usual amphetamine high was different. I wasnt all antsy and it seemed to be slightly more euphoric. I think the hydrocodone might have taken the edge off of the amphetamine.

Another time I take 120 mg codeine with no effect at all