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The Big & Dandy Methoxetamine (MXE) Thread - Chapter 14

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It is a significantly higher dose than people use for sure. However, there are people who use 500mg-1g pretty much everyday, for a lot longer than three months. I don't think MXE is particularly dangerous in terms of risk of death or overdose, but given that some people have complained of kidney/bladder problems from overuse, it looks like that could definitely be a health risk. Probably to a lesser extent than ketamine, but a potential risk nonetheless.
 
professseur said:
It is a significantly higher dose than people use for sure. However, there are people who use 500mg-1g pretty much everyday, for a lot longer than three months. I don't think MXE is particularly dangerous in terms of risk of death or overdose, but given that some people have complained of kidney/bladder problems from overuse, it looks like that could definitely be a health risk. Probably to a lesser extent than ketamine, but a potential risk nonetheless.
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Yup, and people that drink absurd amounts of alcohol get cirrhosis of the liver. If your doing a gram of MXE a day you are asking for trouble. I know there are people out there that do that much. But from this study it seems no worse than alcohol if you ask me in terms of physical damage. It's a good warning to addicts though.
 
I agree with you, that kind of drug use is way over the top and is not a surprise that it has negative effects on health. But having read through most of the big and dandy's on MXE, it does seem like their are a fair amount of people who are abusing it everyday anyways and who continue because they aren't aware of any physical harm it may cause, so this could help some people make some boundaries with their use.

The damage is probably cumulative, so even lower doses everyday may eventually add up with enough time.
 
A gram of a MXE per day.... that would be the equivalent of being homeless and drinking a liter or two of denatured etoh IMO. If you have that much of an issue with the drug well you should be in a detox center. A fucking gram a day??? Mice doing 3 grams of MXE a day??? On my worst binges I think I did 3 grams in 10 days and that was me being TOTALLY OFF MY HEAD for 10 day's. From morning till night not doing anything much besides MXE and a few benzo's and sleeping. Sure there may be a few people out there doing doses like that but they have a serious drug problem. Study makes me feel BETTER about using MXE as long as your not being a twat and using a fucking gram a day every day for three months. How the fuck could you function and hold down a job? Your job would be full time MXE use. WTF???

As for the last comment professseur so how exactly do you arrive at this hypothesis? I know drinking and smoking enough over time will fuck you up BAD. So to will excessive use of MXE. Thing is my bladder works fine and my LFT is 100% normal. I only use occasionally compared to most and vs the 1 gram a day cumulative damage I may as well have never touched MXE in my life. 3 grams per day is just absurd.
 
People get big tolerances after using long enough to the point where they have to use huge dosages, no one would start out doing that much. And it's probably isn't common that people use 1g a day, but I'm sure their are plenty who use ~500mg a day. And if ~2g a day causes significant damage in people over three months (extrapolating the mice model), it doesn't seem that far fetched that a few 100mg's a day could do damage over many months or +year. The mice weren't using 3g/day though, but 30mg/kg, and mice weigh like an ounce.

That said, I've never used close to as much and I think MXE is pretty safe and forgiving of abuse, barring potential mania and addictiveness. I'm just saying using every day over a long period of time could be doing some damage, even at lower doses than those used in the study.
 
Really, tolerance huh? Never would have guessed. The same applies for anything. If your stupid enough or in a bad enough state mentally to end up abusing any substance including food the outcome is never good. A few hundred mg's a day? Ok. On a daily basis... that is the begining of drug dependence, drug addiction soon follows. The most amazing thing about working with substance abusers is that alcoholics never see etoh as being a problem. It's everything else that is the problem. Same as diabetic's thinking oh I'll eat that massive plate of potato mash with corn and chips on the side and walk around drinking coke all day. I don't need that insulin unless my BGL is over 8 (insightless). Fuck me why is my BGL so high can't have been all that sugar I pumped into my body. Is there such a thing as responsible drug use?? For me yes but I am prone to the occasional binge/relapse every few months. My drug use is fairly well regulated on the whole however.

Long term use of Quintiapine or Clozapine and the damage caused... That would be of interest.
 
Hey, whatever man. I never said a person wouldn't be addicted to MXE if they used that much, they obviously would be. But, apparently a lot of people have addiction issues with MXE, so this is still pretty relevant to them. I'm not playing up the harm, but it shouldn't be played down either. Just because significant damage was found at 30mg/kg, doesn't mean damage doesn't happen at all at lower doses, it just has never been tested. Not to mention this is only one possible aspect of harm measured, it doesn't imply that their are no other possible mechanisms for health problems to occur. I agree that MXE seems quite safe with little to no physical harm from moderate use, or even the odd binge, but people DO take this every day, stupid or not.
 
Not playing the harm down just saying that if someone come and reads this thread and think "oh that applies to me, I do x amount of MXE a day..." well they have a problem. Interestingly enough ketamine is being trialed as an anti depressant. Also ketamine is used in the medical setting. What I am saying is dose and frequency ie prescribed dose and frequency or low level dose, no issue. Abuse = issue.
 
Ahh, I see what you were getting at. I agree with your point, it's certainly only an issue once someone crosses over to heavy chronic abuse. Sorry for the misunderstanding!
 
It should also be pointed out that another massive flaw in this study is that no one that is an MXE addict takes all their dose at once. Usually, people stagger doses throughout the day. Nobody goes hey, let's do a gram of MXE in one shot in a syringe.
The reason this has so many people fired up is that all this study proves is that if you plan on doing an astronomical and unrealistic ammount of MXE your gonna have some health problems. I think that it's common sense for pretty much everyone who read this. It would have been nice of the authors of this study did anything to resemble a natural human model of use. But they didn't and all it really proves is that MXE is very very safe (as long as you aren't asking for death by injecting 3 grams a day.
 
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Bladder problems after MXE use are the least of my worries.. it seems to have some serious cognitive impacts.

lovepsychadelics said:
Vs 3 meo pcp or pcp MXE is a kitty cat. Mixing 3 meo pcp and meth... not the best idea I have had.
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Oh, I'm sure. That doesn't mean MXE can't be dangerous in it's own right, however. I love the drug and I think it can be very beneficial, but honestly I think it's dangers have been significantly downplayed. That's not to say we should overplay them, but we need to be careful not to perpetuate myths about the drug that might lead people into unsafe dosing habits.
 
I know it would be best to play it safe and wait 24 hours, but how dangerous would taking mxe 12 hours after 5- APB be? I figure once I've came down completely and my pupils return to their normal size that the risk of Serotonin Syndrome would be minimal. Am I way off base?
 
I don't know, but I'm sure someone here does, so definitely wait for an answer. I wouldn't risk it. I did MXE at the end of 4-FA (but only like 5 hours later) and it was quite bad, a bit scary (more scary afterwards when I found out how bad it COULD have been).
 
I found MXE to be alright after MDMA, you just need to wait until the serotonergic action has dropped to next to nothing... ketamine is a MUCH safer option, just because of the negative interactions that have occurred to other people from MXE and MDxx I really wouldn't recommend it.... but I was able to get away with it.

no_id said:
can you devellop ?
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After heavy MXE abuse (3-4g in about 3 weeks) I could feel myself quite "dumbed down", so to speak. Language was harder to follow, I'd lose certain words on the tip of my tongue and simply be at a loss to what could fill in the gap as well as a number of other symptoms that would point to PFC damage. If my usage had stayed consistent I'm SURE these changes would have been much more drastic, although when I was mid-binge I would simply write it off as "just the MXE". The symptoms lasted quite a while after I stopped using though, although recently it's been clearing up quite a bit.
 
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I too did MXE on the tail-end of MDMA one time, NOT recommended, although i was fine, but i was extremely careful with dosing(low) and timing.

with higher quality MXE, I'm left with a spiritual / well-being feeling(similar to mdma's good thoughts). If i have average MXE, I'm left with a feeling of wanting more MXE :S

I still believe the later to be MXE and it's good, just not like the pre-ban era.

I've hardly abused mxe and keep my tolerance very low still.


I've noticed after-effects from my small MXE use. although very mild, i get this feeling in the front of my head, like just above my eyebrows. Very hard to explain, but it's like; feeling I'm just starring or squinting with my eyebrows at something like when the sunlight shines in your eyes. . Also can relate to the speech thing. finding or getting the correct the word(s) to use can be hard.

Keep in mind this is very mild, and i would rather have these side-effects than the 'come-down' feeling you get from most other party drugs. mxe has nothing close to a come-down feeling.

and a few days after mxe use, i usually feel very tired at points during the day/night.. all this lasts about 5ish days.


[edit] on a side-note; mxe has unpredictable effects. like how alcohol is sometimes unpredictable .

generally i'll only use mxe when other people are drunk, or w/e.. social setting. I might try mxe in a different setting, like getting a haircut and see how that goes ahaha, I'd assume it would be similar to drinking alcohol, so not too good.
 
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Folley said:
After heavy MXE abuse (3-4g in about 3 weeks) I could feel myself quite "dumbed down", so to speak. Language was harder to follow, I'd lose certain words on the tip of my tongue and simply be at a loss to what could fill in the gap as well as a number of other symptoms that would point to PFC damage. If my usage had stayed consistent I'm SURE these changes would have been much more drastic, although when I was mid-binge I would simply write it off as "just the MXE". The symptoms lasted quite a while after I stopped using though, although recently it's been clearing up quite a bit.
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I experienced too some detrimental effect from MXE, more about perception than intellectual capacity related... They vanished with time, generally 1 week is sufficient, 2 to be at baseline. What's the duration of yours symptoms ?
These symptom are not entirely different from some of side effect of serotonergic antidepressant, perhaps these are due to the SRI property of MXE.
There is many ppl who get these type of symptom from SSRI around me (on certain kind of SSRI personnaly I don't have these memory/retrieving problem, I just can't think straight, and this take a while after stopping the med to reach baseline).
After effect problems from my MXE usage seem more due to the dissociating part (NMDA), thought.
 
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Got 1g of this after almost one year of no dissociatives. Wonder if I'll still like it :D
 
Don't worry mate, plan to. Besides my favorite doses were in the 20-40mg range before so I doubt I ever had huge tolerance anyway. I mean I tried going higher a few times but just never found it as enjoyable.

Will probably do like 20mg or something oral when I have some time.
 
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