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Pharmacological options in the treatment of addiction

kmatrixg said:
In response to your question - yes, in the immediate effects of the small dose, my impulsive cravings have been suppressed. I realize that if I really thought about how opiates make me feel, I would want to take them, but in this state the cravings were almost primal in being the only way to fix my then current mood, which was lethargic and apathetic.
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Also besides supressing craving it is important to find out wheter you have underlying problems and were possibly self medicating such as anhedonia, those need to be fixed with a alternative treatment.
 
Anhedonia is pretty common in opiate withdrawals that I've seen people go through..

Am I alone in getting something like "natural opiate-withdrawal pill" ads everywhere now? All I can trace it to wrt tracking is this page....
 
I better do weekly updates on this, but ive had some interesting results, and also things turned very chaotic as i started switching meds around some days, i think ive found what works best now, and i will update in a week.

  • 10mg amp 3 times a day
  • 400mg gabapentin 3 times a day
  • 450mg wellbutrin
  • 25mg amisulpiride (i find after a while it starts causing negative effects and i have to lower the dose to get the effects back, probably in a couple days will need to half the dose again, getting all the positives)
  • 30mg dextromethorphan 3 times a day
  • And drinking my glass of coke slowly with some GBL, there is no reason for me to reduce my intake of GBL as it never caused me trouble or gave me physical dependency issues, i dont dose around the clock

Goal is to keep myself from taking too much amphetamine and stay with the therapeutic dosages, my log isnt that interesting compared to others as i havent got a full blown addiction to everything, altough it can show that pharmaceuticals can have a positive impact on drug intake, i have anhedonia wich GBL abolishes, but i also use it recreationally.
 
TheTwighlight said:
^ why the DXM? Just curious.
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Tolerance prevention, wich is a crucial part of any anti addiction regime so the doses stay low, besides that its a alpha3beta4 antagonist and wich would therefor synergize with the anti addictive property's of wellbutrin.
 
Loperamide for opiate addiction is a wonderful drug. Take a ton of them and it softens the withdrawal a lot, take even more and you can actually maintain on just immodium AD.
 
Im on a stable regime now, i'm just gonna update after 2 weeks wheter i could stay on therapeutic doses of amp or started binging.

- Wellbutrin 450mg
- Amisulpiride 50mg
- NAC 600mg

Thats all it seems to take after i stopped everything and tried things seperate and stuff.

Last time i did end up binging in the end, altough it helped, lets see how this will work, after 2 weeks il have an initial idea, some ocasions i do wonna take a shitload and will allow myself but i have to be able to use amp therapeutically too.

The urge to redose the whole time isnt there or barely there, pharmaceuticals should be used more against addiction, i wish someone that has bigger issue's could try some stuff and keep a log here, as that would be worth alot more then mine.

Basicly i beleive a combination of meds can really be powerfull and strongly atenuate cravings and withdrawals, but cant say much without some experiences, in my case there's a strong atenuation of amp craving.
 
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TheTwighlight said:
I gotcha now. At first I didn't know what to think about the dex. But it makes sense now. I mean, I figured maybe to potentiate an opiate/opioid. Gotcha.
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Yup, stopped it now tough, going back on memantine soon, wich is alot better imo and worked against G tolerance wich DXM doesnt slow at all.

Because of my experience i highly recommend to play around with both DXM and memantine, i had the oposite experience of magicalcat, not liking dxm much but more a fan of memantine.
 
SangerRainsford mate srry for not responding will do soon but your posts need alot of amp haha.
 
After some experimentation ive changed my opinion on the subject, it seems that the combination of wellbutrin and NAC is as effective as a combination of 5 several medications for amphetamine abuse, pharmacological options definatly work, however i will change now that there's no need for excess combinations.
 
Pharmaceuticals have their place in getting clean. For detox, gradual detox, and depression issues, there are many invaluable drugs. It should never be discounted as appropriate depending on the patient.

For long term sobriety, behavioral therapy is a must. Gotta deal with the underlying casual factors. There is not one universal tool. 12 steps for some, therapy for others, you name it. Gotta change the playgrounds and playmates for awhile. But even during this time, certain meds can curb desires, lessen depression, deal with anxiety, etc.. Benzos long term for the newly clean are very easily abused and should be used with caution.

These are just my opinions. Dealt with it my self and with others for a long time. No one tool has a great success rate. Unfortunately, we can't take a pill and be "fixed" . That kind of thinking got me where I was 25 years ago.
But there are very useful meds that can and should be used in conjunction with other therapies to give people the greatest chance of success.
 
Was wondering if Bluelighters have any experience with dextroamphetamine/ methylphenidate substitution therapy for long-standing stimulant use, especially when concurrent with methadone maintenance?
 
Yes, I am aware this is an old thread, but I hadn't seen it before. I thought there were some very interesting references at the beginning...

but let's say medievil is somewhat correct about the pathways governing addiction, and using certain pharmacological substances to block those pathways could temporarily decrease cravings for drugs...wouldn't you have to very quickly quit taking all your drugs of abuse forever, or risk extreme up/downregulation of the pathways controlling addiction...leaving you more prone to addiction and craving than ever?
 
Errm mostly my succes is self delusion posted here, they do help but most comes from efford, only ibogaine from what ive read can really stop addiction, or substitution therapy, dexamphetamine (think they get it controlled like how i asked myself for a controlled dex script have to go to pharmacy 3 times a week) definatly works for me and in study's, still feel craving a bit at times but baclofen makes that go away. Im still gonna order mdpv and stuff too as i dont really want too get over it yet as i can manage my addiction lately, but i have this now im without them and it works.
 
If I were you I'd use the rest of your strip to make a sub nasal sprayer, and use a few sprays at a time, every hour or so, until the WD goes away, and then maintain with as few sprays as possible until it runs out. Using a nasal spray allows you to get the most out of your sub and keep the doses extremely low.
 
First post...
On Baclofen too from more than a year and craving is dead.
Still tapering down to my maintenance dose (maybe will stop at 40/50mg).
Drinking occasionally and never a lot.
Only SE i have is "disrupted" nights divided in 2 parts... probably just dosage related...

@MeDieViL: how is going?
As long-term user (as u seem to be), do you have any specific advice?
Some combined therapy that maybe worked better for you?
 
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emc said:
First post...
On Baclofen too from more than a year and craving is dead.
Still tapering down to my maintenance dose (maybe will stop at 40/50mg).
Drinking occasionally and never a lot.
Only SE i have is "disrupted" nights divided in 2 parts... probably just dosage related...

@MeDieViL: how is going?
As long-term user (as u seem to be), do you have any specific advice?
Some combined therapy that maybe worked better for you?
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Don't worry yourself too much about the divided sleep, it's natural.

Also I haven't seen MeDieViL posting here in quite a while, you might have better luck reaching him with a private message.
 
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