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Any theorys about DiPT's (auditory) mode of action? (Part 2)

Morninggloryseed

Morninggloryseed

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Other thread: bluelight.org/vb/archive/index.php/t-234403.html

I know this stuff is rare but it is still around in some collections.

I had a recent experiment with it and am really intrigued again. Last time the topic was brought up was when Applecore tried to replicate the DiPT effect. I cannot find his report for some reason but here is a link to the program and some of the songs he rendered 'DiPTed'

http://www.klingbeil.com/spear/

https://soundcloud.com/theapplecore/sets/dipt-effect-on-auditory

Which leads to all sorts of other questions and experiments but for now I will just put my notes and speculation and see if I can get others to contribute to this thread.

"Well my experiment wasn't very practical as I didn't spend much time on the****filter, and even with 50mg, I ended up at a full +++. I did get keenly observe the distortions, listening to Beatles which I know like the back of my hand. I have to say, sometimes the type of modulation I would experience would seem to change from song to song. Sometimes voices were normal, guitars downshifted into 5th, horns downshifted by 2 steps, but that would also change; both of us DEFINITELY noted the entire 'timbre' of the modulation would change as the drug began to peak, did peak, and would wane. Finally, I do think the SPEAR program can do a job of replicating some of the modulation DIPT produces"
 
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At 80mg of DiPT, the auditorial effects lasted around 13 hours. I tried sleeping around the +6 hour mark, and it just wasn't happening. At around +10, after 4 hours of silence, I noticed that the effects were clearly still there. My voice was still an octave lower, and talking to people was like talking to space aliens. Anywho, during the experience, it seemed as if the distortion from the DiPT would vary. Listening to Aoxomoxoa, that album was COMPLETELY morphed. It didn't sound the same at ALL. Mountains of the Moon was totally transformed, nothing sounded the same. Jerry and Bob's voices were ALWAYS distorted, while sometime the instruments sounded spot-on. As far as trying to replicate the "DiPT sound", the effects just varied so much it would be hard to pin down exactly what DiPT was doing. Still was a very interesting experience. THE single most annoying thing would have to be my own voice dropping an octave. It didn't freak me out or send me into a panic, was just very bothersome and I remember wishing that at least my own voice would return to normal.
 
I too noticed that I *thought* the effects were well down, but I think it was mostly me getting more and more used to the effect. Later in the evening (next day) a friend came by and shared some tea which kicked things back up. I noted a particular 'whooshy' sound which I soon realized was actually mild tinnitus I experience downshifted!

Next DiPT experiment will involve lower dosages, and prerecorded tones and combinations of tones. Therefore more consistency can be achieved and then actual modulations better observed.

Lococo said:
At 80mg of DiPT, the auditorial effects lasted around 13 hours.
THE single most annoying thing would have to be my own voice dropping an octave. It didn't freak me out or send me into a panic, was just very bothersome and I remember wishing that at least my own voice would return to normal.
Click to expand...

Did you also note that DiPT is a stellar psychedelic, auditory effects aside? I at some level thought my initial trial with DiPT was a fluke (I had a ++++) but my second trial confirms DiPT is indeed a valid psychedelic in its own right.
 
morninggloryseed said:
Did you also note that DiPT is a stellar psychedelic, auditory effects aside? I at some level thought my initial trial with DiPT was a fluke (I had a ++++) but my second trial confirms DiPT is indeed a valid psychedelic in its own right.
Click to expand...

I was having INTENSE CEV's at the beginning, and almost going out of body on some of these. At one point I was looking through a doorway, then all of a sudden I was on the other side of the doorway looking through it, and suddenly, I was back in my original spot, looking through the "front" of the doorway again, all in a matter of seconds. I will have to agree, DiPT IS a wonderful psychedelic, if you can handle not hearing correctly for hours on end :)
 
That sound sample from applecore is pretty accurate.. It does sound like all sine waves get shifted down and the harmonics get all screwed up.

I'm super sensitive to the effect on DiPT, a small dose even 15mg will cause my sound perception to be fucked for 24 hours. I also noticed it seems separate from the psychedelic effects... Smoking DiPT is a really great psychedelic (short lasting) but I would refrain from doing it because I know my hearing would be fucked for over 24 hours.

I also am sensitive to the sound effect from 5-MeO-DiPT, and I get a little bit of it from 4-HO-MiPT too (but strangely, i get none from 4-HO-DiPT...weird!). I also get an intense (DiPT intense), but slightly different sound effect from alpha, N,N-TMT (alpha-methyl-DMT)
 
If smoking DiPT has instant psychedelic effects, but the audio effect is delayed (several minutes) does this mean that the audio effect might be from a metabolite rather than actual DiPT? Also that for me the audio effect lasts a very long time (all day) vs the 5-15 minutes of the psychedelic effect (when smoked)?

What are the likely metabolites (anybody know)?
 
yaesutom said:
If smoking DiPT has instant psychedelic effects, but the audio effect is delayed (several minutes) does this mean that the audio effect might be from a metabolite rather than actual DiPT? Also that for me the audio effect lasts a very long time (all day) vs the 5-15 minutes of the psychedelic effect (when smoked)?

What are the likely metabolites (anybody know)?
Click to expand...
Btw the same goes for it's effects on smell/taste, at least for me. I always found that a lot more intriguing than the auditory effects.
 
There was some speculation awhile back about 5HT-7 being involved somehow, but I think that was pretty much discredited with the advent of selective 5ht7 agonists. As far as I can tell, DiPT is fairly selective for 5HT1A -> 5HT2C -> 5HT2A. Perhaps the very high affinity and likely full agonism at 5HT1a play some role in the auditory effects of DiPT.

Of course, this is only looking at the serotonin system. I would guess that like other nn-substituted tryptamines, DIPT has some affinity for the sigma receptors, which we don't seem to know a whole lot about still. Looking into some papers about auditory transmission didn't seem to be too useful, as glutamate, acetylcholine, and the monoamines all play roles in auditory transmission. The paper did note that the Delta glutamate receptor is especially prevalent in the organs of the ear though, and these receptors are poorly understood. And these possibilites don't even consider the idea of paired receptors. As I recall, "hallucinogenic" 5HT2A receptors are almost always paired with an mGluR (can't remember which one). Maybe something like this occurs with DIPT.
 
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