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Increasing receptor sensitivity with an antagonist. Would this work?

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purplehaze147

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If I took hydroxyzine, one of it's actions is a serotonin antagonist, for a week and then stopped this would increase the amount of serotonin receptors I have correct?
 
Not necessarily. While neurons try to maintain homeostasis, often neurotransmitter antagonism isn't quite equivalent to neurotransmitter deficits. It'd be nice to have a model that predicts exactly how the brain will react in response to repeated challenge with a drug, but we just plain don't have such a model, and intuitive predictions can be misleading. IIRC 5-ht2a antagonists can actually downregulate 5-ht2a!
 
I was just wondering cuz I know ssris down regulate serotonin receptors so I was thinking an antagonist might have the opposite effect. What can I do to be able to trip more often and get the most out of my trips? My drug(s) of choice r various 5ht2a agonists but I have a huge tolerence. I plugged 2.5mg of 25I-NBOH and I'm not even trippin, just mild visual distortions. The threshold for it is like 100 micrograms. I'm not on any meds that would stop a trip I'm just on suboxone, it's because I tripped 3 times this week lol.
 
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purplehaze147 said:
I was just wondering cuz I know ssris down regulate serotonin receptors so I was thinking an antagonist might have the opposite effect. What can I do to be able to trip more often and get the most out of my trips? My drug(s) of choice r various 5ht2a agonists but I have a huge tolerence. I plugged 2.5mg of 25I-NBOH and I'm not even trippin, just mild visual distortions. The threshold for it is like 100 micrograms. I'm not on any meds that would stop a trip I'm just on suboxone, it's because I tripped 3 times this week lol.
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There is nothing, theoretical or otherwise, that will let you trip three times in the same week with no loss in intensity. Either pace yourself or try something with a different mechanism of action.
 
endotropic said:
There is nothing, theoretical or otherwise, that will let you trip three times in the same week with no loss in intensity. Either pace yourself or try something with a different mechanism of action.
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Honestly, using Serotonergic psychedelics in such a rapid sequence is dangerous. Risk of Serotonin syndrome is high and psychosis is a very real possible.
 
Honestly, using Serotonergic psychedelics in such a rapid sequence is dangerous. Risk of Serotonin syndrome is high
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5ht2a agonists don't cause serotonin syndrome. Don't confuse side effects from serotonergics with SS.

Serotonin syndrome is what killed Libby Zion, not what happens when you take too much "molly".
 
sekio said:
5ht2a agonists don't cause serotonin syndrome. Don't confuse side effects from serotonergics with SS.

Serotonin syndrome is what killed Libby Zion, not what happens when you take too much "molly".
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Fully aware, but if I'm not mistaken 5HT2A agonists mimic Serotonin correct? If they were to build up high enough in the body, they could cause Serotonin Syndrome on there own due to the fact they quite strongly mimic Serotonin? Also, isn't downstream release an issue?
 
Not really. 5ht2a is just one of many serotonin receptors, so while 2a agonists do mimic serotonin at that receptor, they don't neccesarily have the same effects as broad-spectrum releasers. (c.f. nobody claims LSD can substitute for MDMA, or a SSRI) Overdoser from 5ht2a agonists doesn't have the same symptomology of serotonin syndrome, either - most of the symtpoms of 5ht2a agonist overdoses seem to be psychological, or the pther effects of the compound start to come into play because of the extreme dose level.

The downstream serotonin release from 5ht2a is not of the same magnitude of SSRIs or SRAs.
 
St. John's Wort is the only substance I've found that can directly upregulate 5HT2a (and other) receptors. Note that this is only something I've read and not something I've tried, and it happens to be the epitome of a dirty drug, eliciting a myriad of random serotonergic/dopaminergic agonism/antagonism/reuptake inhibition to varying degrees depending on dosage, and has supposedly shown MAOI qualities in vitro, but once again this is only theoretical.
 
DPT said:
St. John's Wort is the only substance I've found that can directly upregulate 5HT2a (and other) receptors. Note that this is only something I've read and not something I've tried, and it happens to be the epitome of a dirty drug, eliciting a myriad of random serotonergic/dopaminergic agonism/antagonism/reuptake inhibition to varying degrees depending on dosage, and has supposedly shown MAOI qualities in vitro, but once again this is only theoretical.
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link for this?
 
DPT said:
St. John's Wort is the only substance I've found that can directly upregulate 5HT2a (and other) receptors. Note that this is only something I've read and not something I've tried
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Good, 'cause a personal bioassay couldn't tell you anything about receptor upregulation.

ebola
 
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