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preparing for first LSD trip

T1gersxjaw

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Aug 6, 2013
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So the other day my friend called and said he found a good LSD hook up. I've never tried a psych, aside from DMX which I hated, but I've heard how good it is from other people and I'm up for giving it a try. Honestly, what should I expect on my first trip? It's also important to note that I suffer from chronic depression (dysthymia) and am on Prozac 40mg, Wellbutrin XL 300mg, and recently started Abilify 5mg. Will any of those meds affect the trip? Also should I have anything prepared when I come down or if it is a bad trip, like xanax or something? Opinions and experiences would be appreciated.
 
The best way to avoid a bad trip I've found, is to have the proper location. My suggestion is out in the woods (with at least one friend for safety and fun purposes), though make sure it's the kind of forest that's soothing rather than creepy. I suggest finding a clearing, somewhere away from trails so there's no worry of bumping into strangers if you're not clear-headed. Make sure it's a pleasant, sunny day, gloomy weather can give forests a creepy vibe.

Secondly, have some lighthearted movies on a phone, for when you're coming up. They will distract you and prevent you from worrying. Your thoughts as you're coming up will affect the balance of the trip, so you want to be as relaxed as possible. I suggest watching some quirky, fun, kids movies (i.e Flubber, Toy Story, etc); they're good for soothing you when you're tense. Take a break about 40 minutes after taking the tab though, as it's easy to get so focused on a movie that you don't really notice the trip (at least at low doses).

As for the medications you're taking, your antidepressants will directly interact with the LSD, at least from a biological perspective. How it will affect the experience depends on a bunch of variables, primarily dosage. Most people find that SSRIs weaken 5HT-psychs (LSD, Shrooms, 2Cs, MDA, etc) effects. I suspect this is primarily due to the downregulation of 5HT2A receptors, the primary type of receptor affected by serotergic psychadelics, and Wikipedia seems to corroborate this possibility:


What this means, is that not taking the drug the day you trip probably won't make a huge difference, as the reductive effect is actually the result of long-term brain adaptations, not the drug's acute chemical effect.

I would not take the SSRI with acid due to the risk of serotonin syndrome. The risk with acid is much less than it is when combining SSRIs with MDMA (which can be very deadly), but it's still there. The Wellbutrin (Buproprion) is safe with acid (though it could interact and affect the trip), as it works primarily on dopamine, with no binding to serotonin receptors or transporters.

The Abilify is not unsafe with acid, though it will likely significantly reduce the effects of it, as it is an antagonist/inverse agonist of all of the serotonin receptors. Since acid works primarily by stimulating those receptors, you're essentially canceling it out (depending on your dose). I suggest not taking it if you want to have any kind of trip. It's also odd that you've been prescribed it, as it works through the opposite mechanism of your Prozac, reducing serotonin activity (while Prozac increases it). Together, they pretty much negate themselves. Both drugs have other mechanisms as well, but their two primary mechanisms of action contradict each other.

Xanax would be great to take right off the bat if you have anxious-tendencies (i.e if you're obsessively worrying about having a bad trip). It'll mellow you out while still allowing you to enjoy the acid. However, if you're not to anxious about your first time with acid, I'd suggest seeing how you do without it, and saving it in case you start going down the bad trip route. It's nice to have a clear head, and you'll remember the trip better if you're not under it's influence (Benzo's have mild amnesiac effects).
 
You will love it because it will be so incredibly euphoric and educational for you.

I can't feasibly see you having a bad time at all, or getting anything less than amazing lessons from it.

It will be uncomfortable from time to time, but you'll be having so much fun..who cares, right?

Read above though. Those drugs youre on will make it difficult to have a proper trip because they will limit the effects. However, take any advice from others with a grain of salt. If you are taking a medicine every day, then it is not the same tolerances that someone may read on the internet. Your body is used to it. Its your daily medicine for you. Not a large amount that you got from a peer reviewed article.

Have fun. wait for some other posts and think it over.

Get some good music. Plan ahead. Have fun. Get some fun toys to play with.

Most importantly. Let go. Don't fight it. Don't expect anything. Just go with the flow.

Whatever happens, letting go, and knowing it is temporary will make it very special for you.
 
Honestly, what should I expect on my first trip?
A perceived change in your surroundings and thought patterns.
It's also important to note that I suffer from chronic depression (dysthymia) and am on Prozac 40mg, Wellbutrin XL 300mg, and recently started Abilify 5mg. Will any of those meds affect the trip?
Ask your doctor(s). Mixing drugs is dangerous.
Also should I have anything prepared when I come down or if it is a bad trip, like xanax or something? Opinions and experiences would be appreciated.
An NWA album. Having not taken any drugs is a good start to the healing process.
 
So the other day my friend called and said he found a good LSD hook up. I've never tried a psych, aside from DMX which I hated, but I've heard how good it is from other people and I'm up for giving it a try. Honestly, what should I expect on my first trip? It's also important to note that I suffer from chronic depression (dysthymia) and am on Prozac 40mg, Wellbutrin XL 300mg, and recently started Abilify 5mg. Will any of those meds affect the trip? Also should I have anything prepared when I come down or if it is a bad trip, like xanax or something? Opinions and experiences would be appreciated.

I tried LSD when on lexapro, it almost completely dimished the effects. Prozac, belonging to the same class of medications (SSRIs), should have the same effect unfortunately. It will not completely block the effects, but you will mainly feel mental and physical stimulation, with some added confusion. There will be almost no visual effects and the mental aspect of the trip will be greatly dimished. This could maybe be compensated for by simply taking more LSD, though I never got around to trying that as I quit the SSRIs quite soon after I started them because I felt they were not doing anything at all for me.

Edit: abilify also, I'm sorry, this is not going to work I think. I looked it up and it acts as inverse agonist / antagonist at the same receptors LSD work on. Therefor it should completely block the effects, rendering the drug useless.
 
I tried LSD when on lexapro, it almost completely dimished the effects. Prozac, belonging to the same class of medications (SSRIs), should have the same effect unfortunately. It will not completely block the effects, but you will mainly feel mental and physical stimulation, with some added confusion. There will be almost no visual effects and the mental aspect of the trip will be greatly dimished. This could maybe be compensated for by simply taking more LSD, though I never got around to trying that as I quit the SSRIs quite soon after I started them because I felt they were not doing anything at all for me.

Edit: abilify also, I'm sorry, this is not going to work I think. I looked it up and it acts as inverse agonist / antagonist at the same receptors LSD work on. Therefor it should completely block the effects, rendering the drug useless.

with the abilify, i've been on the medication for less than 2 weeks. I've also not taken it the past 3 days in preperation for the trip, which hopefully, will take place tonight. Do you think it will still affect it?
 
If your trip is strong expect experiences that you are not able to fully understand, explain, or put into logical thought. That's normal, just go with it, enjoy the unusual. If you experience any severe anxiety don't worry, be happy all trips end and you'll be right as rain wishing it had lasted longer.
 
I have no clue how the medications might affect your trip, I've only done LSD one time and I did it with molly(don't recommend this for your first time unless it's at a rave like how I did it), it was fun and got into my head and took away some of my depression. Be sure to have a good friend with you keeping the positive energy flowing. That is the key here, positivity. Don't look at scary things. I remember thinking about the devil and god at the rave I went to because of all the weird faces I saw. Also, I experienced loads of anxiety during the trip but I let it all loose on the dance floor at the rave I did it at. The anxiety or comedown lingered in my chest for about a week. I think xanax might help but I'm not sure. Also, don't smoke weed, maybe after the trip but don't before or during, it could lead to trouble.

Make sure to have food and an assortment of drinks that might put you in good spirits in case you're hungry. Orange juice, sodas, chocolates, your favorites etc.

I would experiment with a low dose of shrooms before trying LSD but if that's not possible then by all means. Good luck man, it's relatively safe.
 
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