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Aminoindane Compounds

B

blowjay

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Joined
Jan 7, 2010
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There isn't much on bluelight about this family, I just found an interesting compound through random searching, DOM-AI, I found it in Novel Psychoactive Substances: Classification, Pharmacology and Toxicology
edited by Paul Dargan, David Wood

mixed reports in rats but I hadn't considered any DOx subs for the AI's, makes sense considering there is MDAI and MDMAI out there. I would really like to hear more reports on 2-AI or the n-methylated version, are these looked over due to lack of interest in effects or is there a challenging synthesis to blame? Wonder what putting a ketone on there would do, especailly in MDAI's case, hell two ketones could be thrown on there though I am sure there is probably someone with better knowledge than me who is going to say that doing either of those things will make the chemical unstable or simply cannot be done. I am sure that a methyl group added on the carbon right before the amino group could make 2-A1 a little more interesting.

So what is shaking with this family? Anyone have any idea why we aren't seeing these pop up more often? 2-AI has been of interest to me for quite some time, today I just realized how much more could potentially be done with the family thanks to the random book find.
 
I don't know much about its mechanism but it did make an appearance a few times on erowid in the past without much negative effects, I was just wondering with all the other crazy things being made today why things such as this seem to fade away when much more could be unearthed that would lead to more research in potentially new and 'legal' psychedelic compounds.

Gotta keep pushing ahead with discovery, bump for someone to contribute more, all I do is try to spark up things it seems.
 
The story I've heard about 2-AI is that it's an unremarkable stimulant that for some reason gives an enormous rush upon injection. This doesn't really make it sound recommendable, but it's sort of like a big red button labeled "do not press". The 1-aminomethylindanes seem more promising, binding-profile wise.
 
Doesn't sound like a good thing to me either, I haven't heard much about the family other than what I have posted, I am hoping there is more out there that I am not aware of.
 
I remember 2-AI getting bad reviews. Something about it being an unremarkable stimulant that wore off too quickly (like after an hour and a half).
 
Thirded. Recently had a chance to try MDAI, and I gotta say I'm a big fan. Most of what people like about MDMA, minus the neurotoxicity. Reminds me a lot of snorting Oxytocin, except much longer lasting.

Not something I'd use every day (I'm more a pure stim+nootropic than entactogen/empathogen fan), but it goes alongside 4-Aco-DMT as one of those "whoa, this stuff is really good for an RC" every once in a while drugs.
 
I think most people that didn't enjoy MDAI didn't get MDAI or got horribly impure stuff. When I mixed MDAI with just a bit of methylone, it was like a much less toxic roll and was extremely enjoyable. It was even better with 2C-D and it wasn't bad at all by itself. Reminded me of MDE with a longer duration and I happen to enjoy MDE. It also had no redose impulse, unlike MDXX and their beta-ketone cousins.

The aminoindanes probably have some undiscovered gems. I heard from a lab in China that they were having synthesis problems with aminoindanes and stopped trying when I was inquiring about MDAI. This is one of the best labs in China so if they were having problems, I imagine the other labs were faring even worse off.
 
That probably explains some things about why they aren't more to the forefront, I was curious about MDAI but never followed into it much because of the concerns with synth problems/fake product.

Thank you all for the input on this, this is a family I am interested in, the last 3 posts have piqued my interest more.
 
Explains why MDAI is so freakin hard to find. I literally don't know of a single RC vendor in the US carrying the legitimate product at this point, despite it being pretty clearly outside the federal analog act.

Shame that shady vendors tainted the drug's reputation like that. :(
 
I haven't seen MDAI from a legit vendor in a long time either. It is definitely a shame as it is a wonderful chemical.

I think part of it is that MDAI doesn't have the push of the cathinones or APB families that were making the rounds that made people define MDAI as a "crap" drug. I'll even admit that at my peak of mephedrone and methylone use, I too scoffed at MDAI in comparison.

The vendors lost a LOT of money on MDAI though, whether it was impure or just didn't sell well, so it has a stigma here in the states. Maybe with the US catching up and banning everything, MDAI may show up again.
 
I'd have liked to see how a modern tasting of indanorex would be received. As far as stimulants go, it seems fairly benign, and at least it's been studied. Unscheduled stimulants, must not have had much abuse. Still, it differs from the amphetamine pharmacophore quite substantially.
 
sekio said:
So what, it raises blood sugar? Or just normalises it?
Click to expand...

I don't know but they were comparing metformin with indanorex in the paper - for reactive hypoglycemia specifically which is what I have: Giugliano D, Luyckx A, Binder D, Lefebvre P. Comparative effects of metformin and indanorex in the treatment of reactive hypoglycemia. International Journal of Clinical Pharmacology and Biopharmacy. 1979 Feb;17(2):76-81.

That's literally all that I can find on it.
 
I am curious about reduction of the alcohol and/or possible methylation. I may also be curious about what removing a carbon would do, can't find much about this compound anywhere but why go out so far with the carbons? I can understand the alcohol being used as it seems to be the way to go with many anorectics (Phenylpropanolamine comes to mind first).
This post of indanorex is a whole different type of compound though than I was initially invisioning seeing in this thread.
 
Hammy said:
I'd have liked to see how a modern tasting of indanorex would be received. As far as stimulants go, it seems fairly benign, and at least it's been studied. Unscheduled stimulants, must not have had much abuse. Still, it differs from the amphetamine pharmacophore quite substantially.
Click to expand...

Hear Hear. It would be nice to see what emerges from a wider variety of monoamine releasers not based on the phenethylamine skeleton.

ebola
 
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