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Opioids Plugging question

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pinkriot

pinkriot

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Joined
Dec 15, 2010
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Hello and thank you for looking at this thread! I've been here on bluelight for longer than I've been registered but I only lurk and search until I find my answer. Now I have a question that I haven't been able to answer with searching through threads. I am very opiate tolerant and familiar with all routes of administration but have only plugged opiate pills a handful of times. I never thought my first thread would involve poop but here I am lol

Is plugging your pill of choice a waste of time if one has diarrhea and has had diarrhea for awhile?

I've been on antibiotics for basically 5 months straight so it is an unfortunate side effect. I wasn't sure if perhaps the solution to be plugged would/could be absorbed into the waste instead of the body. I know you should always empty your bowels before plugging.

Thanks guys %)
 
I would be more worried about it whooshing out of my ass with the rest of the waste...

The runs tend to leave the bowel very clean of fecal matter I might say... It's all on the outer bits of your ass now... LOL

Try to wait in between bouts if you can. That would be a real solution in this situation.
 
So this might actually be a good thing!

I would certainly wait until after a recent go and in between. The few times I plugged it felt like I had the runs anyways (same with any uh, liquid that would end up there) ;P

I've read about doing the same process but up the hoo-ha but for some reason that kind of freaks me out. I feel like it could mess up the delicate pH of the area or give the yeasties. Might be the only RoA I've yet to try lol
 
pinkriot said:
So this might actually be a good thing!

I would certainly wait until after a recent go and in between. The few times I plugged it felt like I had the runs anyways (same with any uh, liquid that would end up there) ;P

I've read about doing the same process but up the hoo-ha but for some reason that kind of freaks me out. I feel like it could mess up the delicate pH of the area or give the yeasties. Might be the only RoA I've yet to try lol
Click to expand...

Do not use your va-jay-jay to administer drugs besides birth control... It is only used as a last resort outside of STD prophylactic administration...
 
Plugging opiates will likely help to alleviate the GI issue you are describing. Nice when a side-effect is actually helpful to you.

I'm with Jay on the not plugging things in your lady parts. Especially considering you're already on antibiotics, I can't imagine anything good coming from that.

Perhaps you should have some pro-biotics with your opiates? Not within my realm of personal experience but sounds sensible.
 
damn that's a long time to be on antibiotics...yuck :( sorry to hear that.

the reason you're experiencing the 'runs' in the first place is because antibiotics, especially administered over such a long course of time, pretty much go through your guts and instead of just wiping out the bad bacteria that is present, it just goes through and wipes the majority of it out, including the good bacteria.

if your doctor hasn't already, they should have Rx'ed or suggested some pro-biotics - acidophilus, something with the name "flora-" in the title of the drug like 'florastor' or something...anything with live cultures. Even eating some yogurt once or twice a day would do wonders for your intestinal health.

as for vaginal administration of opiates - nope. yuck. don't do it. not good for your vag, and would likely waste your drugs.

rectal administration - yay! as one said above, try to wait in between 'shits' for best results. Use the liquid sparingly, just enough to dissolve your drug completely plus a wee bit more. Even if you feel like you've got to go after administration, try to pass it off for a minute and relax and think of something else. For me, it usually goes away if I just relax and don't concentrate on it. And other times, ahhhh yeah I gotta go...
Luckily, I do believe that the drugs are absorbed rather quickly in the rectum (anywhere as short as 5 minutes, and almost all are absorbed by the 10 minute mark - I don't have an exact source on this, so I could be wrong, but I also speak from personal experience where I've "lost it" aka had to poo pretty damn fast after administration...but, I still got high.)

Good luck and happy plugging!
 
having fecal matter in the rectum definitely can impair/impact the amount of drug that ends up getting absorbed into the bloodstream vs into feces. Normally, if there is fecal matter in your rectum, you will know it and you'll have the urge to go to the bathroom, because the feces is only expelled from the large colon into the rectum when you're about to go to the bathroom. It depends a lot on what you're plugging too, in my experiences, fat soluble drugs, the more soluble they are in lipids, for example with methamphetamine or buprenorphine, I've never once experienced diminished effects no matter how bad I had to go to the bathroom prior to administration.
 
tricomb said:
having fecal matter in the rectum definitely can impair/impact the amount of drug that ends up getting absorbed into the bloodstream vs into feces. Normally, if there is fecal matter in your rectum, you will know it and you'll have the urge to go to the bathroom, because the feces is only expelled from the large colon into the rectum when you're about to go to the bathroom. It depends a lot on what you're plugging too, in my experiences, fat soluble drugs, the more soluble they are in lipids, for example with methamphetamine or buprenorphine, I've never once experienced diminished effects no matter how bad I had to go to the bathroom prior to administration.
Click to expand...

Not to mention...

Drug that are very fat soluble are not really what you want rectally... You might want to check the water solubility... This grossly effects the absorption...
 
Yes a good rule of thumb is if it won't work up your nose, it won't work up your rectum, of course there are exceptions, ketamine I believe is poorly absorbed via plugging
 
Psychedelic Jay said:
It depends on pH...

Neither of us are particularly right...
Click to expand...

I see the variables in why you say that 'neither are particularly right;' however, because the cell membrane is lipoid, lipid-soluble drugs diffuse most rapidly. Small molecules tend to penetrate membranes more rapidly than larger ones. at least, when referring to passive diffusion.

"Most drugs are weak organic acids or bases, existing in un-ionized and ionized forms in an aqueous environment. The un-ionized form is usually lipid soluble (lipophilic) and diffuses readily across cell membranes. The ionized form has low lipid solubility (but high water solubility—ie, hydrophilic) and high electrical resistance and thus cannot penetrate cell membranes easily." - Merck Manuals - Pharmacokinetics - Drug Absorption
 
I know for a fact that I'm not experiencing placebo effect when rectally administering methamphetamine (but that's fat AND water soluble, likely why it's absorbed 99% or more via the rectal ROA) and the pH of methamphetamine varies. And for those using crystal meth, this variability is even higher and yet I have yet to hear anyone say that plugging their dose was not as effective or more effective than their default method of ingestion.

Another example is midazolam. I've used it extensively and through every ROA, and oh my god never again will I plug a solution with a pH below 5, I highly recommend that everyone uses pH strips if your working with known acidic compounds. Even injecting it at pH ~5 it burned more than slamming a gram shot of morphine too fast. Its very water soluble but midazolam is not very soluble at neutral pH 7, leading to people and big pharma bringing the pH down to like 5.

Other benzodiazepines that are NOT water soluble but DO rapidly cross the rectal walls due to their high lipophicity would be diazepam, which is famous for being a life-saving breakthrough for epileptics. The diazepam is delivered rectally using a special tapered syringe and contains (IIRC) 40mg diazepam gelc (DiaSTAT). These syringes even come with a pre-set dose, so that children and others who may not require the full 40mg can get a preset dose (like 5mg, 10mg, 20mg, 30mg, etc) the dose is pre programmed by the dispensing pharmacist using a dial which is then locked (and loaded) and then inspected by the patient for accuracy.

If only water soluble drugs could cross the rectal walls, then I wouldn't have seen this medication save lives (good luck hitting a vein on someone who's seizing.) and I stand by my statements, that both fat and water soluble drugs can be effectively used rectally.
 
tricomb said:
I know for a fact that I'm not experiencing placebo effect when rectally administering methamphetamine (but that's fat AND water soluble, likely why it's absorbed 99% or more via the rectal ROA) and the pH of methamphetamine varies. And for those using crystal meth, this variability is even higher and yet I have yet to hear anyone say that plugging their dose was not as effective or more effective than their default method of ingestion.

Another example is midazolam. I've used it extensively and through every ROA, and oh my god never again will I plug a solution with a pH below 5, I highly recommend that everyone uses pH strips if your working with known acidic compounds. Even injecting it at pH ~5 it burned more than slamming a gram shot of morphine too fast. Its very water soluble but midazolam is not very soluble at neutral pH 7, leading to people and big pharma bringing the pH down to like 5.

Other benzodiazepines that are NOT water soluble but DO rapidly cross the rectal walls due to their high lipophicity would be diazepam, which is famous for being a life-saving breakthrough for epileptics. The diazepam is delivered rectally using a special tapered syringe and contains (IIRC) 40mg diazepam gelc (DiaSTAT). These syringes even come with a pre-set dose, so that children and others who may not require the full 40mg can get a preset dose (like 5mg, 10mg, 20mg, 30mg, etc) the dose is pre programmed by the dispensing pharmacist using a dial which is then locked (and loaded) and then inspected by the patient for accuracy.

If only water soluble drugs could cross the rectal walls, then I wouldn't have seen this medication save lives (good luck hitting a vein on someone who's seizing.) and I stand by my statements, that both fat and water soluble drugs can be effectively used rectally.
Click to expand...

Who said it didn't work?

Also, who said you were experiencing placebo?

We were both right, you know?
 
It was implied that only pH and water solubility allowed a drug to cross the rectal walls that's what I was addressing, I wasn't putting any words in anyone's mouths I just rambled about my $0.02 :) both right indeed 8)
 
I plugged .25 of meth 45 min ago in a 1/2ml syringe using 30 units. Why don't I feel it?
 
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