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Misc What does naltrexone really block?

downfallin

downfallin

Bluelighter
Joined
Jul 8, 2010
Messages
188
Location
Somewhere in California
Hello everyone, I`m a guinie pig for vivitrol, the monthly shot that slowly releases the chemical naltroxone into the body over the period of a month. As far as opiates go, it seems to be an impenetrable force field worthy of a star wars reference. I`ve only tried testing this once about a year ago and did some H on day 27 and didn`t feel shit. I didn`t repeat this experiment because it was the most frustrating thing in the world to go out, cop, get all excited, do a shot and then not even feel a single shred of relief.

But as for alcohol, I really can`t tell too much of a difference on or off it. It is a bit less euphoric but to say that all the euphoria is blocked would be a definate over-exaggeration. It is still somewhat enjoyable, which is strange seeing as it was first used to treat alcohol addiction.

I have also experimented with salvia while on the shot and didn`t feel anything after smoking a gram of the 20x extract. I also know someone who was put on it for a methamphetamine addiction and have heard of it`s usage in all different types of situations including a marijuana addiction. 8). I was told by my doc that it blocks only the mu-opioid receptor but this is obviously not true.

I just had my wisdom teeth removed two days ago and I was being highly resistant to the numbing shit. They had to shoot me with that big ass needle in my gums and mouth 12 times before they could go yanking my teeth out of my face without me feeling it. I was literally shaking in pain by the time they got me all the way numb and the dentist and assistants were dumbfounded. Didn`t even get any notrus oxide:X though I went out and did a whipped cream whippit shortly after haha (which worked but less gave euphoria and a different experience than I was accustomed.) I can only assume that the naltrexone had some part to play in this.

I`m beginning to feel tired of being a guinie pig for this drug, and I never feel quite right anymore when I`m taking it, but I am hesitant to stop because I know myself, and I live in a town where you don`t need a connection to get dope. You just walk down a certain street and it`s there.

Well if anyone has any more light they`d like to shed on the situation that would be nice, other than that, Much love to all my internet junkies out there :) peace and <3.
 
'm not surprised that it works best for blocking opiates/opioids. It hits those mu receptors and locks them down tight. As far as the alcohol goes, they are really unsure how and why exactly it works in this case. It is believed to (supposed to) block some of the euphoria of drinking and also once someone has quit drinking it is supposed to help supress the urge to drink as much. There are different reason and theories but pretty much has to do with the reward system in your brain. This is why it can be used for other type drug addictions such as meth. It has even been used for problems with gambling, porn addiction and kleptomania. That would make sense if it has to do with the reward systems..anything that causes an imbalance/overdrive of the pleasure centers in the brain. So technically it does only block mu opioid receptors. It just also affects other pleasure/reward centers in the brain...which all do not specifically have to do with the mu receptors.

As far as the issues with the numbing at the dentist I really think this was a coincidence. I don't see how this drug would have any affects on novocaine or lidocaine or any such "numbing" drug. These type drugs work locally (wherever they are injected) and not at the brain level. Basically the way they work is by screwing with the sodium channels in the local nerve cells they don't allow the nerve impulses to leave the area and therefore travel up the nervous system and into the brain. There are tons of reasons why sometimes numbing doesn't work as well in some people or just some of the time. Sometimes some dentits just miss the nerves they are trying to hit and numb up. An infection in the area to be numbed causes changes in the pH which doesn't allow it to work as well. Even just being nervous or anxious can cause it to not work as well or to wear off more quickly. Different dentists use different drug (combos) and some do not work as well as others and the list goes on. I just don't think it could affect anything to do with local numbing of nerves.
 
I was told by my doc that it blocks only the mu-opioid receptor but this is obviously not true.
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It also blocks the delta and kappa opioid receptors. (Salvia acts on kappa-opioid - and as you saw, it's blocked).

I just had my wisdom teeth removed two days ago and I was being highly resistant to the numbing shit. They had to shoot me with that big ass needle in my gums and mouth 12 times before they could go yanking my teeth out of my face without me feeling it.
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Your wisdom teeth are pretty deeply innervated. it can take a shitload of lidocaine for some people before it is numb enough for them to go to work. Don't worry - it's unlikely the Vivitrol blocked the lidocaine. It's not unusual for people to be really resistant to it. Maybe it has to do with the epinephrine mixed in with the lido, to minimise the bleeding- it also means the lidocaine can't move around the tissues well.

The only things Vivitrol should block are the opioid-based drugs, and Salvia. I'm not quite sure why they claim it's a alcohol addiction treatment. I guess addictions work in wierd ways.

It's better to stay on the naltrexone rather than battle with opioid addiction, I think.
 
crimsonjunk said:
Fentanyl will work.
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If it works, then what happens when more of the naltrexone is released? I would think it would put you into withdrawals, but I'm not sure.

SteeleyJ said:
buperenorphine will still work, it should displace the naltrexone on the opioid receptors.
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If it's displacing it then it's putting you in precipitated withdrawals. I know someone who took naltrexone too soon after suboxone and went into precipitated withdrawals that way, so I'm not sure which has the higher binding affinity.
 
Tommyboy said:
If it works, then what happens when more of the naltrexone is released? I would think it would put you into withdrawals, but I'm not sure.



If it's displacing it then it's putting you in precipitated withdrawals. I know someone who took naltrexone too soon after suboxone and went into precipitated withdrawals that way, so I'm not sure which has the higher binding affinity.
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How the hell would fent work? It`s an opiate synthetic or not... and I had to be clean for 8 days off of sub before getting the shot because the naltrexone would push it out so I doubt that would work either, but I`m really not trying to go use opiates on top of this shot in the first place. I was thinking more along the lines of hallucinogens, thinking about doing a CWE extraction on some morning glories or something, but the salvia trip made me doubt it would work, and I`ve heard of people having very diminished trips because of it. Was also thinking DXM maybe but I think that drug does something with the opiate receptors also.........idk. But I kindof want a little non-opiate release thats more interesting than what alcohol brings to the table.
 
^ The reason fentanyl would work is due to receptor binding affinity. I wouldn't recommend it though due to overdose risk and the fact that you'd get a diminished high.
 
The only case in which you should be taking fentanyl with naloxone in your system is if you've been hit by a car and need emergency pain control. Otherwise you are playing a very dangerous game.
 
I got the vivitrol shot about 3 weeks ago and when i got it the doctor told me fentynal would still work tried that and really good effects did a opana 40 gel shot it up and felt about 90% of it havent tried dope yet tho. I shot a panda the day after i got the shot and didnt feel anything so i guess after 2 1/2 weeks the shot wore off :) hope this helps everyone
 
joshevans2008 said:
I got the vivitrol shot about 3 weeks ago and when i got it the doctor told me fentynal would still work tried that and really good effects did a opana 40 gel shot it up and felt about 90% of it havent tried dope yet tho. I shot a panda the day after i got the shot and didnt feel anything so i guess after 2 1/2 weeks the shot wore off :) hope this helps everyone
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Damn joshevans2008, that`s crazy dude, I`m glad you tested that out, I`ve been wondering but afraid to fuck around with it. If I did it`d probably be with the dope though haha. Just the easiest and most effective thing to get for me. I don`t know how I would go about finding fent. And I`m assuming that you shot the fent too right? Just sounds dangerous to me with my dropped tolerance to blast some fentanyl; strange a couple months ago I wouldn`t have cared in the slightest. If I do any testing I`ll be sure to post it too. thanks :)
 
pinpoint said:
^ The reason fentanyl would work is due to receptor binding affinity. I wouldn't recommend it though due to overdose risk and the fact that you'd get a diminished high.
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Nah, I think it's just because it's really potent. It's like how you can 'shoot through' suboxone using enough heroin, but make no mistake the suboxone has the higher affinity.
 
I have never found naloxone to be effective in combatting alcohol addiction. A few years ago I asked my psychiatrist if he could prescribe me some because I thought it would help me stop drinking, but he never ended up doing it. Over time I had to start taking suboxone to get off opiates, and it NEVER did anything to block either the cravings or the effects of alcohol. I have always wanted to drink, and I have always been able to get drunk.
 
as others said, it is an antagonist of the opioid receptors. thats why salvia didnt work, it affects opioid receptors.
did it only block the dissociative effects or it didnt do shit at all? im not aware of what other receptors it binds to, but AFAIK it should only stop the opioid receptors related effects am wrong?
never thought about that. anyone knows the answer?
 
ComfortablyNumb95 said:
as others said, it is an antagonist of the opioid receptors. thats why salvia didnt work, it affects opioid receptors.
did it only block the dissociative effects or it didnt do shit at all? im not aware of what other receptors it binds to, but AFAIK it should only stop the opioid receptors related effects am wrong?
never thought about that. anyone knows the answer?
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It kind of did something after the gram to my dome, it gave me like an uneasy slightly off feeling but it wasn`t the salvia I was used to even with the body feeling.
 
InHerOwnWrite said:
I have never found naloxone to be effective in combatting alcohol addiction. A few years ago I asked my psychiatrist if he could prescribe me some because I thought it would help me stop drinking, but he never ended up doing it. Over time I had to start taking suboxone to get off opiates, and it NEVER did anything to block either the cravings or the effects of alcohol. I have always wanted to drink, and I have always been able to get drunk.
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Naloxone =/ Naltrexone
 
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