Just another subjective bioassay opinion, but I've come to the conclusion that (if no unknown mechanisms are involved) some batches of Methoxetamine could well have a light, but "irreversible" and thus cumulative MAOI action that builds up slowly when taking chronic low, sub-threshold dosages (or lasts some days after one huge dosage). Can't find an other explaination for these outstanding reactions when combining this with low (<=5 mg/d) of amphetamine. Hypomanical flight that lasts for days and weeks with next to no subjective exhaustion or comedown... (while the MXE is continued). Confirmed by people who didn't know about my drug use, this was way more than subjective amphetamine "smartness" manic... It's about two years since then, and I still miss the social and mental energy I've experienced...
Other samples of what was called to be the same substance had not entirely, but quite different effects and lacked this specific one. I'd agree to that there is at least a range between sedative, psychedelic-dissociative MXE and speedy, cold MXE batches where with the latter it was impossible to achieve something like a "hole", leaving one in a strange, overstimulated mindfuck for hours. Not totally sure, but would make sense that this was the MAOI one.
Memantine, being a (relatively) clean NMDAI, is even at 40mg+/d in no way comparable to that MXE (5-10mg/d), both tried in different combinations. On the other side, it helps quitting the MXE without rebound.
Now I would love to give Tranylcypromine a try (being also a dopamine releaser itself)... it's not marketed here and haven't seen a supply yet. Off-topic, but still.. anyone having experiences? Would be interesting to compare.
At last, yes... I think I've had some blood pressure elevation here and there, but nothing serious and even while sleeping was not that difficult, Clonidine solved both with ease.
The other thing- I can't assure that I don't suffer of long-time after effects (light cognitive impairment, NMDA/dopaminergic disregulation, whatever)- having taken so many psychoactives -many of them scripted by stupid doctors giving neuroleptics for sleep and all that- I can't say what I would be now without that history. Subjectively I feel Methoxetamine wasn't that bad, compared to SSRI and neuroleptic compounds...