PsychoPsychonaut
Bluelighter
- Joined
- Jan 25, 2009
- Messages
- 77
Hey, I have a question about benzos and euphoria. From my experience and others reports the top 2 most euphoric (legal) benzos are Temazepam and Alprazolam. I read a thread in the ADD Forum that Temazepam was Primarily (Non-selective) to any GABA subunits and that Alprazolam has an affinity for the α2/3 subunits. I have also read in a Pharmacological google book that "Partial agonists selective for α2/3 subunits of benzodiazepine-sensitive GABAa receptors hypothetically would cause less euphoria, be less reinforcing and thus less abusable, cause less dependence, and cause fewer problems in withdrawal." Now here are my questions. If what is stated here is to believed then why are Temazepam & Alprazolam the most euphoric legals if Temazepam is non selective? Also why would Alprazolam be euphoric at all and cause such addiction and withdrawal problems if what i read in that google book is true? My initial thoughts on BZD euphoria was that the ones which produce the most of it would be selectively targeting specific subunits but alas this seems not to be the case. Could someone with proper knowledge on the subject please explain the correlation between Benzodiazepines and euphoria?
Here are the resources
http://www.bluelight.ru/vb/archive/index.php/t-485261.html
http://books.google.com/books?id=cO...&q=which gaba subunits cause euphoria&f=false
Here are the resources
http://www.bluelight.ru/vb/archive/index.php/t-485261.html
http://books.google.com/books?id=cO...&q=which gaba subunits cause euphoria&f=false