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The Big & Dandy Methoxetamine Thread - Hit #12 - Oh look, it's MXE o'clock

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ordered a gram on a whim! muahhh a! amazing! MXE ! like good ol DXM trips
 
I've never seen the words good, DXM and trips in the same sentence before.
 
CathodeRayTube said:
I can't seem to find an answer to this... can MXE be dissolved in vodka for volumetric dosing via oral route?
Will it dissolve ok and remain stable for a month or 2?
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It will definitely dissolve if it's highly pure. I'd say it's very likely to be stable for that long. I've heard stories of ketamine retaining potency dissolved in saline in a vial for a decade.
 
Anyone heard of a decent MXE dissio replacement on the market?

It seems that MXE quality has dropped so much for the past few month that Im not even getting anything sweet at all.
 
3-meo-pcp sounds neat, but sketcher to dose and more manic. It might just be tolerance. My current batch of MXE is as good as any I've had in years, though i hear there is some iffy stuff going around from normally good sources.
 
3-MeO-PCP is NOT a replacement for MXE, I can tell you that.

As Golem said, there's plenty of great MXE making the rounds. The last gram I bought was fire. Purest I've ever had.
 
3-MeO-PCP produces somewhat different effects from MXE, 3-MeO-PCP is a more subtle and clean dissoactive high, you are less "fucked" (in reasonable doses)
 
3-MeO-PCP of what ive heard is not a clean dissiociative. What is a clean dose for u Bone14? Some said that 10mg is already too strong.
 
I've only had my hands in 250mg 3-MeO-PCP, the time I had this I had some tolerance from too frequent MXE use (I usually buy 2-3g and take 20-40mg daily until the bag is empty and then I take a break)
10-12mg insufflated was my preferred dose with this (Include some tolerance in these doses) - The stimulation feels very clean and non-toxic, no elevated heartrate or vasoconstriction. The high was like a non-confusing MXE high, but still somewhat different from MXE.
 
I can also say that 3-MeO-PCP has a very clean and lucid feel, especially in comparison to MXE. I like doses 8-15mg orally, but I think I have a slight tolerance to dissociatives, nothing huge though. IME, the higher doses still feel clean with very little deterioration in speech and coordination; however, the manic thought process can become intense.

On another note, a few nights ago I IVed 45mg of MXE. I actually find the extreme level of confusion during the first few minutes entertaining. Like a big slap in the face that makes you forget where you are, who you are, and that you've even taken anything. Am I alone on this one?
 
I personally hate it and it's something i'm trying to avoid like the plague, probably because i've had it more than enough and/or because it just doesn't feel healthy to me... Whatever that may mean :| Paradoxically, nowadays i sometimes think it was somehow funny back then, but when you're actually stuck in this indescribable mental mess, it's not that entertaining anymore.
 
I have been using MXE in threshold doses for the antidepressant effect. I use about 90 - 100 mg for this, and I do have a medium sized tolerance to this type drug, based on others descriptions of their use. I cannot advocate it's use for this purpose due to lack of research and unknown long-term effects, but I can say it's been effective when nothing else has.

I experience a definite stimulation which is very noticable around four hours after dosing. I take it with 0.5 mg alprazolam, and often will take another 0.5 mg to reduce at least the subjective feeling of stimulation.

I am curious if anyone else has noticed this effect, and if it happens with ketamine at this dose(which is 0.5 mg/kG bodyweight).

I also am curious if anyone might know what is causing this. My ideas:
1) a form of glutamate rebound(due to onset at approx. 4 hours)
2) an active metabolite (again due to time of onset)
3)the seratonigenic activity of MXE vs ketamine (if ketamine does not have this effect)

I notice that if I take anything remotely stimulating during this time, it will potentiate it to the point of unbearability. This includes D-amp, caffeine, and stimulating kratom. In fact, it even potentiates it the next morning, when the direct stimulating effect of MXE has been gone for ten hours. It also does not seem to interfere with sleep quality like glutamate rebound from alcohol.

It seems well known on drug boards that NMDA antagonists potentiate opiates (usually DXM is mentioned). Perhaps it sensitizes your receptors in some way. And this could be why it works as an antidepressant.

I get the feeling there is much unpublished research, and someone, somewhere knows a great deal about this, so cough it up.;)
 
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edzeppelin said:
I have been using MXE in threshold doses for the antidepressant effect. I use about 90 - 100 mg for this, and I do have a medium sized tolerance
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Is this 90-100mg per day or per dose? If per day, how do you spread out the dosing?
I can't definitely answer most of your questions, but I do believe MXE has much more seratonergic activity than ketamine, and it is overall much more stimulating than ketamine- it's the difference between classifying MXE as an 'up' dissociative and ketamine as a 'down' dissociative. They are very different in that regard, but I am not versed in the pharmacological actions that cause this difference.
 
Is this 90-100mg per day or per dose? If per day, how do you spread out the dosing?
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I take it all at once, sublingually. Through trial and error, I have found this to be a good dose for me, and then I realized this is the same amount being used in all the ketamine clinical trials. Supposedly MXE is more potent (recreationally) by weight. I do not know how this is determined, but for maximizing the AD effect, this amount feels right.

There is also currently a clinical trial for ketamine which is testing if dosing two or three times per week would be more effective. I have found 3x/week to be most effective, but I am concerned about tolerance rendering the drug ineffective, and that would completely suck.

Can anyone explain how potency by weight is determined vs say ketamine or 3-MeO-PCP?
 
The after effect of MXE is definitely stimulating, thats one of my favorite parts. The new study in the UK shows MXE has no activity on dopamine but I find it hard to believe personally (perhaps it's indirect activity that was not measured).

Also NMDA antagonists potentiate opiates and prevent tolerance, you can read about this on PubMed not just drug forums and from what I've also read ketamine (and presumably MXE as well) causes the growth of new serotonin and dopamine receptors so that likely plays a role in the anti-depressant effects as well.

Complete prevention but stimulus-dependent reversion of morphine tolerance by the glycine/NMDA receptor antagonist (+)-HA966 in neuropathic rats.
http://www.ncbi.nlm.nih.gov/pubmed/10719957

Effects of Dextromethorphan on reducing methadone dosage in opium addicts undergoing methadone maintenance therapy: A double blind randomized clinical trial
http://www.ncbi.nlm.nih.gov/pubmed/10870744

The glycine/NMDA receptor antagonist (+)-HA966 enhances the peripheral effect of morphine in neuropathic rats.
http://www.ncbi.nlm.nih.gov/pubmed/12406530

The use of NMDA-receptor antagonists in the treatment of chronic pain.
http://www.ncbi.nlm.nih.gov/pubmed/10870744

Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists.
http://www.ncbi.nlm.nih.gov/pubmed/9783723
 
e1evene1even - thanks for the published studies. This is so frustrating, because I do have a chronic illness in addition to depression, and there is published research back to the mid-eighties that NMDA antagonists and opiates help with pain and depression/bipolar, but researchers don't offer treatment, and on the treatment end, doctors just don't want to know. They want me to suffer in silence and be compliant. Then you are labeled a drug user if you take your illness into your own hands, do your homework, get your own medications and self-treat (to life-changing success, I might add).
 
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