Taking St Johns Wort after taking an 5-HT2A receptor agonist (NBOMe)

[jamesmartin]

I felt that this question belongs in Advanced drug discussion as a fair amount of "neuro-knowledge" is required to answer it.
So ill get straight to the point..

- I took NBOMe last night by mistake. (NBOMe was sold as LSD. However after taking the tabs i confront my dealer and he admits its NBOMe. What a scumbag)
- I have been taking St Johns wort for 2 weeks daily (3 times a day aka recommended dosage) leading up to the trip. I was using it as a natural treatment for my depression.

I havent taken my dosages of St Johns wort today and i was looking for some advice on here before i do so... If anyone can shed some light or some answers on the following questions it would be very much appreciated...

I was wondering if it would be safe, detrimental or maybe even beneficial to continue using St Johns wort after taking NBOMe ?
I don't want to down regulate my 5-ht2a receptors even more. I also don't want serotonin syndrome or anything.

What effects does St Johns wort have on 5-ht2a receptors ?
What effects does St Johns wort have on 5-ht2a receptors after using a 5-HT2A (serotonin 2A) receptor agonist

Thanks again



Seeing this is a harm prevention forum i also thought i'd type a little bit on how i realized my tabs sold as "LSD" wern't LSD. Perhaps this info can help others doubting weather they have LSD or another scumbag/harmful compound.

Unfortunately i dosed last night on what i thought to be LSD.... i took 2 tabs and realized the effects were noticeably different to what i've felt when doing LSD multiple times in the past. The first obvious sign was that the tabs were incredibly bitter to the point where some of my tongue (the part where i was holding the tabs) was going numb and tingly. Along with this, was a horrid chemical/acidity taste.
I came to the conclusion and realized that this was likely not acid so i spat the tabs out after 5 mins of holding them on my tongue. I also drank some water to try and get rid of the nasty taste.
Despite doing this ^ and thinking that spitting them out and drinking water would stop my trip within 20 mins i was starting to feel NBOMe's effects :0

Pure euphoria was felt along with a desire to sit there and just zone out...
(with LSD i feel like exploring and walking around, going on nature walks, etc. On this i felt the total opposite) . It was a still a nice feeling i'm not going to lie but it still wasn't what i asked for or paid for -_-
The desirable psychedelic aspect of this compound was hardly present. There were visuals, positive thoughts, etc. However, something big was lacking. There was no deep thinking or introspective. The visuals were undetailed, repetitive, generic and boring. My mind and headspace wasnt as clear as it would be on LSD. I just felt like i wanted to sit there and enjoy the euphoric feeling.
I didnt think about life and other things such as beauty and the world like i do on LSD.

Anyways before i ramble any more...
Conclusion = NBOMe and LSD are different drugs .End of story<Lesson learnt. They are like apples and oranges.
Unfortunately many dealers are not there to make you have a good time. They want to make money. So they can either order a chemical online for cheap and put it on blotter. Or they can go on a quest to find a lsd manufacturer (very rare and hard to find)

 

[sekio]

LSD is a 5ht2a agonist as well... if you haven't had any problems with lsd+sjw, then don't expect any with nbome+sjw.

saint johns wort is a filthy drug that has a wide variety of effects, it inhibits the reuptake of serotonin, norepinephrine, dopamine, GABA glutamate etc. but not through direct mechanisms. this paper even suggests chronic hyperforin treatment upregulates 5ht2a.

tl;dr nothing to be worried about

 

[jamesmartin]

LSD is a 5ht2a agonist as well... if you haven't had any problems with lsd+sjw, then don't expect any with nbome+sjw.

saint johns wort is a filthy drug that has a wide variety of effects, it inhibits the reuptake of serotonin, norepinephrine, dopamine, GABA glutamate etc. but not through direct mechanisms. this paper even suggests chronic hyperforin treatment upregulates 5ht2a.

tl;dr nothing to be worried about

May I ask why you describe St Johns Wort as "filthy" ? Haha
You confused me .
You said it was filthy but then went on to talk about its benefits like how it upregulates 5ht2a ......:S

 

[golden1]

May I ask why you describe St Johns Wort as "filthy" ? Haha
You confused me .
You said it was filthy but then went on to talk about its benefits like how it upregulates 5ht2a ......:S

filthy like LSD is. as in it does a whole lot of stuff pharmacology wise.

 

[Foreigner]

SJW prevents reuptake of several neurotransmitters, but it doesn't really address the root issue which is that the receptors themselves were agonized into down-regulation. In short, it's not going to harm you, but I'm not sure what good it will do. You just need to abstain for a while and let the receptors regenerate.

As for SJW being "filthy"... I don't really get it. *shrug* I've used it successfully in my practice, but it only works on a certain kind of patient.

 

[MrSpeedyG]

IMHO if you were taking St Johns Wort for a few weeks all the way upto your trip then it will probably be safe to be taking the days after...

I agree with SJW being "filfthy" although maybe that isnt the word, moreso, inconsistent with its active ingredients in terms of what of and how much, but also what the active ingredients even are exactly... my point and others being the exact pharamocolgical mechanism of it isn't set in stone or anywhere even close and brands may vary heavily as IIRC there isn't much quality control on it.

If it works for your depression then great, myself personally I noticed I days I have taken it roughly 4 or so hours later I just have a sense of well-being and can't figure out why until I go back and remember about taking SJW! Others have reported it is a godsend some the opposite.

But anyway, without getting off-topic, you'll probably be allright in this case. If you want to be safe, take a few days off it but seeing as whatever was in the SJW for taking it that long and upto the trip whatever is in it that could cause some adverse reaction would most likely already have done so.

 

[bob_arctor]

It is filthy in the way that it has effects that are not highly specific, so instead of just binding, for instance, one subtype of one certain receptor, it affects multiple receptors

 

[sekio]

I agree with SJW being "filfthy" although maybe that isnt the word, moreso, inconsistent with its active ingredients in terms of what of and how much, but also what the active ingredients even are exactly... my point and others being the exact pharamocolgical mechanism of it isn't set in stone or anywhere even close and brands may vary heavily as IIRC there isn't much quality control on it.

It is filthy in the way that it has effects that are not highly specific, so instead of just binding, for instance, one subtype of one certain receptor, it affects multiple receptors

this is what i meant by "filthy". there's little to no accepted standard of which components in sjw are actually psychoactive. and hyperforin messes with at least 5 major neurotransmitters....