Can I just say, being involved with BL for a good 10 years now, this is the most useless info thread I've ever seen - and there is generally nowhere on the internet containing reasonably easy-to-access and complete D-amph information.
erowid redirects to generic amphetamines, contains no doseage/halflife/BA/etc info. Wikipedia seems to contradict itself or just cross reference info from general amphetamines.
I get that d-amp isn't exactly the 'big guns' - and regular amphetamine information will be 'close-ish' and in some cases legitimately the same, but could someone who has the knowledge/access to the knowledge please just blank this thread and post something solid?
These are the kinds of drugs kids are usually playing with which only makes it that much more important IMO to make accurate information easily accessible.
No offence intended to the people actually offering some reasonable infos in this thread. It's just a mess.
The reason for this is simple, dextro-(+) and Levo-(-) amphetamines in a ratio of 1:1, make up racemic amphetamines. This is why it directs you to basic amphetamines as the effects are extremely similar except the following exceptions:
Dextroamphetamine
A potent central nervous system (CNS) stimulant that increases striatal dopamine levels more than levoamphetamine in rodents. Dextroamphetamine has greater effects on dopamine levels than on norepinephrine levels. It's prescribed to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.
Mechanism of Action: An amphetamine that enhances the action of dopamine and norepinephrine by blocking their reuptake from synapses; also inhibits monoamine oxidase and facilitates the release of catecholamines. Dextroamphetamine is a more potent agonist of the TAAR1 then levo-
Therapeutic Effect: Increases motor activity and mental alertness; decreases motor restlessness, drowsiness, and fatigue; suppresses appetite.
Pharmacokinetics: Well absorbed following PO administration. Metabolized in liver. Excreted in urine. Removed by hemodialysis. Half-life: 7-34 hr. Oral: 90-95% Bioavailability. Onset of Action 45 mins
Intranasal Mucosal atomization device (sterile water mixed with dextro-): 75-90% Bioavailability (depending on study) with onset of action at 30 minutes.
Levoamphetamine
May have a greater effect on cataplexy, a symptom that's more sensitive to the effects of norepinephrine and serotonin. Levoamphetamine has relatively more balanced effects on dopamine and norepinephrine levels than dextroamphetamine. In some individuals, the levoamphetamine component of MAS products, including Adderall, may improve treatment response compared to dextroamphetamine alone. The levo- isomer has a slightly greater effect on the heart and the peripherals (this is why it can make people very jittery vs dextro-)
The BA of both levo- and dextro- are similar for both oral and insufflation.
Both levo- and dextro- have identical pharmacodynamics, but the binding affinity and biomolecular targets do vary.
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Adderall is a mix of 2 different Levo- Salts and 2 different Dextro- Salts.
Dextro- is 3-5x more potent then the levo-,
Levo- is also known to cause tremors and is more likely to make you jittery.
The best route of administration for both levo- and dextro- is oral as snorting doesn't give you the "rush" something like coke or meth would give you due to how long it takes to have an effect (45 mins oral, 30 mins snorted)
If you are going to snort it, mix it with sterile water, then filter what you can or it will just plug up your nose and drip down into your stomach. Either way though, the onset of action is not affected that much by snorting, but you will get a much higher effect if you just eat them. Oral is ~90%-95% and it will last way longer vs snorting.
Idk about Levo- as it makes me more jittery then a coke addict snorting meth.
