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DNRI + 5HT2 related psyches

S

slo mo

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What can one expect when combining these, a stimulant DNRI and a 5HT2 related psychedelic (L, 2c-x etc) ?
Would the stim potentiate the dopamine and norepinephrine activity that the psychedelic binds to at a high degree?
Are there HR issues here? SS can't occur, but what can that could be unsafe while considering reasonable doses?
 
the dopamine and norepinephrine activity that the psychedelic binds
Click to expand...

You may be a little confused here... most classical psychedelics are serotonin receptor agonists.

Generally combining stimulants and psychedelics results in... more stimulation. Increased risk of panic attacks, hypertension, etc, but those are dose-dependent and unlikely at 'normal' usage levels.
Most people find LSD and the 2c- series stimulating and euphoric enough that they wouldn't reasonably need a NDRI on top of that.

If you want to try the combination, I would keep doses low and avoid redosing on the stim. if you are prescribed e.g. Ritalin, it's probably Ok to just skip your dose.
 
sekio said:
You may be a little confused here... most classical psychedelics are serotonin receptor agonists.

Generally combining stimulants and psychedelics results in... more stimulation. Increased risk of panic attacks, hypertension, etc, but those are dose-dependent and unlikely at 'normal' usage levels.
Most people find LSD and the 2c- series stimulating and euphoric enough that they wouldn't reasonably need a NDRI on top of that.

If you want to try the combination, I would keep doses low and avoid redosing on the stim. if you are prescribed e.g. Ritalin, it's probably Ok to just skip your dose.
Click to expand...


Don't the classics have broad receptor activity? I know most are said to bind to 5HT2a as well as others, but even some 2c's have Dopamine activity, but IIRC LSD has norepinephrine activity as well (aMT too but that is a releasing agent). If the NDRI was a low dose with a normal dose of L or possibly 2c-e or 4 AcO DMT, would the Dopamine effects be changed. No intentions of a stim binge or psychosis to follow, no need for that:p Thanks for the advice, plan to follow that for sure.

Nobody else replied, maybe this combo (psyche + NDRI) hasn't been tried that often?

What would be some compounds NOT to mix with NDRI?
 
most classical psychdelics lack significant affinity for dopamine receptors at typical dose levels - in any case most of the activity comes from primarily serotonin & adrenergic receptors. in any event, a NDRI won't block synaptic receptors and wouldn't be expected to reduce the effects of most psychdelic drugs.

the only trip report on erowid i can find for lsd+stimulants involves some bozo who snorted "3 ritalins" (sic) and ended up having a panic attack. It certainly didn't seem to kill the trip! I think most people avoid stims for this reason, most of the time you shouldn't have a problem staying awake on LSD...

I wouldn't mix any of the triple monoamine releasers (AMT, AET, MDxx, cathinones) with NDRIs. Avoid DXM (it is a SNRI) as well as other SNRI or NRI drugs, as they can cause hypertensive crisis. I would also avoid, e.g. yohimbine, and MAOIs, for the same reason. (Don't get activity at NE/DA%HT receptors confused with being a NRI/DRI/SRI- they are not the same thing.)

As long as you can deal with the anxiety/stimulation issues (after all, NDRIs basically activate the fight-or-flight reflex), doing psychedelics, cannabinoids, dissociatives, opioids, benzos etc should be fine.
 
Some psychedelics do have activity at NE and DA transporters and receptors but they don't appear to be all that important to the effects. With some psychs that have a strong bodily component, they may be a bit more important but 5-ht2a and 5-ht2c are still the primary targets. What DNRI are you taking? That class could fit anything from something milder like buproprion to something much stronger like ritalin or cocaine. Stimulants and psychedelics generally are not thought to be a desirable combination. They won't necessarily be dangerous, but they aren't really ideal. Compounds not to mix with NDRI's would include maoi's and perhaps ND releasing agents like amphetamine. Also drugs that cause strong vasoconstriction.(some more exotic psychedelics fall into this category)

If you want more information about the theoretical aspect of this type of pharmacology, I would highly recommend reading James Kent's Psychedelic Information Theory and taking a look at some of the lectures on Youtube by Dr. David Nichols.

http://psychedelic-information-theory.com/
 
This is a bad idea most of the time for the simple reason that I myself, personally, cannot trip too hard without negative bodily effects, mainly cardio. This is with psychedelics alone. A stim on top of that? I have a slightly trippy super stimmy night, not cool.
 
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