and even if you had found such literature, it would be relatively useless as the nbomes are not only full agonists, but they have extremely high binding affinities, and overdoses seem to be sporadic and due to some unknown mechanism of action.I've found absolutely no information on this combination. I'm certainly going to avoid it. I can't even find any literature on mixing a full agonist and a reuptake inhibitor/serotonin releaser.
After speaking with a few people who have tried this combo and after doing some research I have decided to test this out. I will tread carefully and report back my findings.
People have died or had worrying symptoms from regular doses of nbomes alone. Other people take doses that are 10-20x greater with little physical complications. Asking people about such a combination will do you no good. These people whom you have asked obviously don't have any formal knowledge of the subject, I mean, you came to a forum dedicated to that and the people here don't know shit about it. You think the people that have done it know any better?
Stop getting high on combinations of the chemicals you're limited to (Because I know you'd choose LSD and MDMA over this any day),you don't know at all what you're fucking getting yourself into, you're being bad to the community.
Think about this, let's say 1 in 1000 people that do 25i-NBOMe die. That number is not correct, by the way, it's for hypothetical purposes.
Now that you know that, you would realize you'd need about 1000 people who have used the combination of 25i and methylone together to know the anecdotal dangers. However, that still wouldn't give you a clue about the dangers of this combination.
Now you should realize the ignorance of your attempts to reassure yourself by asking a small group of people who have done the same reckless thing.
Listen, you don't ask people that have made the mistake you are wanting to do if you should do it, it doesn't make sense.
and I'm sure plenty of people have enjoyed this combo and will enjoy it safely.
However I'm also sure that this combo will cause more deaths than 25i alone, which is a scary thought. It will also probably increase the chances of having an unexpected overdose by whatever mechanism causes nbomes to be so much stronger sometimes from the same dose.
I think it'll work fine. I did 250mg MDMA on the tail end of a quite strong 25i and 25c combo trip. Was great fun. The hangover was fairly brutal but it was a long night! As for the deaths/danger concern, I repeat my personal theory regarding those who have died on NBOMEs: it didn't poison their bodies, they had psychedelic freak outs /siezures and injured themselves. Make sure you are with good friends.
That said I also agree that it's not necessary. NBOMEs are so amazing they're pretty intensely euphoric on their own.
A friend of mine had a very serious (fortunately non-fatal due to medical intervention) seizure after unknowingly combining an NMOMe that he presumed was acid, with MDMA. At the hospital they said 7 people have died recently doing something similar. Prohibition seems unlikely to solve this, but it certainly seems true that these are not substances to be taken lightly. Not that any drug is to be 'taken lightly.' But you know what I mean.
They re-dosed what I believe was 25B-NBOMe (I can't be 100% on the variant, but it was one of them) a few hours after the initial dose + an unknown quantity of MDMA. There were no other drugs involved, but I would point towards the possibility of some kind of serotonin crisis. That's purely speculation based on the nature of the combo, obv. I have heard of seizures in connection with NBOMe before on a few occasions, but am unsure of whether other drugs were involved. Even if they aren't likely to cause one alone, the fact that they can do so in combo is also cause for concern of course, given the increasing trend of taking what the media might sensationally refer to as 'a cocktail.'
None of the other people at the party experienced problems, but nobody else re-dosed on NBOMe, they all switched to Ketamine/more MDMA at that point. The person that did redose has never had a seizure before to my knowledge