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Psychedelic with no seizure risk?

RhythmSpring

RhythmSpring

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I want to give a friend a psychedelic as a gift, but he had epilepsy as a child, and is therefore wary of seizure-causing things. I believe he is not taking any medication for it currently, as he hasn't had a seizure in years. He is in his late 20s, and the majority of his seizures occurred when he was in his early-mid teens. He was having lots of little seizures, but he also has had a pretty bad grand mal seizure once or twice.

Are there any psychedelics with practically no risk of seizure, just to be safe? Salvia, perhaps? Mushrooms, maybe?

Thanks.
 
Generally all serotonergic psychedelics carry a risk of seizure in those predisposed to it.

Just be careful. Stressful events of any sort could precipitate an episode. Best to have a sitter around.
 
So perhaps those more intelligent than I might postulate what might make one Psychedelic more or less likely to cause siezures than another? Would those Psychedelics that are generally described anecdotally as being lighter than others & thus less likely to be stressful be the most likely candidate? Or would you perhaps examine a particular Psychedelic drugs history of human use & examine the number of incidence of siezure? Perhaps combining these search criteria & others one could ascertain the Psychedelic least likely to cause a seizure.

Then again, perhaps just serious attention to dosage detail & setting might be enough to mitigate the risk, regadless of compound.

Sorry, I've kinda asked more questions than I've asnwered here...
 
sekio said:
Generally all serotonergic psychedelics carry a risk of seizure in those predisposed to it.

Just be careful. Stressful events of any sort could precipitate an episode. Best to have a sitter around.
Click to expand...

So Salvia, a non-serotonergic drug, would not pose a risk of seizure?
 
I don't know, honestly. Salvia is pretty unpleasant for most. It really wouldn't suprise me if it precipitated a seizure.

Even things like MDMA/methylone will carry *some* risk. But honestly, I don't know. It's going to be very personally dependent.

If you keep doses low, and keep the environment fairly controlled there shouldn't be a problem. Especially if he hasdn't had a seizure in years. But there are never any guarantees.
 
I dunno-I know a lot of people who enjoy Salvia (especially at the more reasonable/lower doses). Also, I don't think unpleasantness of experience qualifies as a cause for epileptic seizure.
 
He's in his late 20s. He hasn't had a seizure in about 15 years and, needless to say, he's been through a lot of stressful situations.
 
ketamine should be ok...

Pharmacology & Physiology in Anesthetic Practice said:
Ketamine-induced excitatory activity occurs in both the thalamus and limbic systems without evidence of subsequent spread of seizure activity to cortical areas (Ferrer-Allado et al., 1973). As such, ketamine would be unlikely to precipitate generalized convulsions in patients with seizure disorders. Indeed, ketamine does not alter the seizure threshold in epileptic patients (Celesia et al., 1975). Although myoclonic- and seizure-like activity may occur in normal patients, EEG evidence of cortical epileptic activity is absent and ketamine is considered to possess anticonvulsant activity
Click to expand...
 
That's what I'm thinking, if you have access to it (if using a benzo, just be sure it's one of the ones that are efficacious as anticonvulsants, such as diazepam). OTOH I don't know enough about the pathology and treatment of seizures to be sure. It works for grand mal seizures though, so this seems a promising route to explore.

Not sure about the duration of its anticonvulsant activity (its metabolites seem to have that property though), quick lookup shows differences in rats and mice...
 
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I'm pretty sure clonazepam is the best benzo vs seizure. Thing is, it'll strongly decrease effects of any psychedelic too.

Maybe just have it on hand if things go wrong?
 
Is it not likely that applying Diaz prior to what's likely to be a rather cautious experiment might quite heavilly reduce the Psychedelic effects?

Personally, I suspect that the ops friend will be fine so long as a few precuations are observed. But I am NOT a doctor & a history of even one Grand Mal is at least a little concerning. Nontheless, it's been ages since that event & sensible behaviour should reduce the risks of a repeat.

Please be extremely careful going into this. Some short acting Psyche such as 2c-c or perhaps a lighter 4-Sub such as 4-ho-met might be a good starting point..?
 
si ingwe said:
Is it not likely that applying Diaz prior to what's likely to be a rather cautious experiment might quite heavilly reduce the Psychedelic effects?
Click to expand...

Yeah that seems likely, for some reason I just assumed they'd be going for a solid +++. On the other hand, fearing a seizure might lead to negative thought processes.
 
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Fagott said:
I'm pretty sure clonazepam is the best benzo vs seizure. Thing is, it'll strongly decrease effects of any psychedelic too.

Maybe just have it on hand if things go wrong?
Click to expand...

I wonder if psychedelic activity is directly proportional to seizure risk, then?

Having it on hand in case of a seizure doesn't make sense. A grand mal seizure may last less than a minute. Diazepam will take much longer than that to kick in. Prevention is the only way, here.
 
Indeed, & I doubt the option of IV Valium is advised or even likely to be possible.

So perhaps we're talking about pre-loading with threshold dose of Diaz, provided the ops friend has no tolerance & then adding a threshold or slightly higher dose of one of the lighter Psychedelic.
 
as never said diazepam can be used rectally in this case, the procedure ain't pretty though.
You use your elbow to open it up then pop in the pill - I was trained to do it on a fake bum once ><
 
RhythmSpring, You are a very knowledgeable poster but there is not any reason to ever give someone any psychedelic if they have or have had epilepsy symptoms. The only situation where this would be acceptable is if a doctor was doing human trials or proven treatment in a very controlled environment.

If you want to give your friend a gift, then bring that friend to a concert, or out for a day of hiking, just show them you care about them and have good times. A psychedelic is not the only gift to show the true divine.

Benzo or no benzo this conversation shouldn't be happening. That is just my opinion.
 
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