Serotonin Syndrome

[Microload]

Ok - I am panicing here.

I took about 250mg of MDMA 6 days ago. I had a great time, nothing bad happened. It was my first time doing mdma.

THEN, the next morning i took 100mg of 5htp. then 6 hours later took another 100mg (because i had read on this forum that it helps with comedown). Then what happened to me can only be described as serotonin syndrome.

It was 24 hours after I dropped, and I felt the 'come-up' feeling again. Except this time it was filled with dread. I was sweating. I was shivering. I was zoning in and out of consciousness. My chest hurt. My head hurt. I was in absolute hell.

Luckily I didn't die.

But now, 6 days later I still can't keep food down and I am EXTREMELY depressed. Like, the most depressed I've ever been in my entire life. For no reason too. My life has been going great lately and now I have no motivation to do anything and i keep puking.

My head hurts and my vision is weird. What the hell do I do here. I am so scared.

 

[Black Rabbit of Inle]

Did you seek medical attention?

Did you take anything else that may have contributed?

eg:

Other prescription and over-the-counter drugs that can raise serotonin levels alone or in combination to cause serotonin syndrome include:

Serotonin and norepinephrine reuptake inhibitors (SNRIs), a class of antidepressants including Cymbalta (duloxetine), Effexor (venlafaxine), and Pristiq (desvenlafaxine)
Monoamine oxidase inhibitors (MAOIs), a class of antidepressants including isocarboxazid (Marplan) and phenelzine (Nardil)
Bupropion (Wellbutrin, Zyban), a drug prescribed for depression and smoking cessation
Trazodone (Desyrel), a drug prescribed for depression
Migraine treatments such as Axert (almotriptan), Amerge (naratriptan), Imitrex (sumatriptan), and Zomig (zolmitriptan)
Pain medications, including Actiq, Fentora, Sublimaze (fentanyl), Demerol (meperidine), Talwin (pentazocine), and Ultram (tramadol)
Lithium (Eskalith, Lithobid), a mood stabilizer medication prescribed for bipolar disorder.
Dextromethorphan, a cough suppressant found in many over-the-counter and prescription cough medicines or cold medicines
Medications prescribed for nausea, such as Kytril (granisetron), Reglan (metoclopramide), and Zofran (ondansetron)

 

[stardust.hero]

Moved: TDS --> BDD

 

[hatrix]

You would know if you had serotonin syndrome. Symptoms are VERY severe and often lead to death....

Think puking constantly. Just never stop, super high temperature, can't even stand, blurry vision, etc. It's almost certain death if you actually have full blown serotonin syndrome.

 

[Venrak]

If you did have serotonin syndrome, the symptoms of depression and vomiting, as well as dizziness are not surprising. Serotonin has a vast multitude of receptor subtypes that influence many things suck as the way we feel emotionally, perceive the world around us, perceive ourselves, as well as physical things like nausea and vomiting.

You should be avoiding drugs right now, no antidepressants, no more 5-HTP, and definitely no MDMA. Perhaps consider talking to a doctor, you don't have to go into your drug use, just that you bought 5-htp for therapeutic reasons and accidentally took too much.

Hope this helps. Hang in there

 

[Microload]

I most definitely had serotonin syndrome. My symptoms are exactly as described by the definition.

I just don't want to feel depressed anymore. I hate it. What can I do ?!?

 

[NeighborhoodThreat]

Speak to a doctor if you're still experiencing these symptoms, as recommended by the other posters.

 

[Microload]

Speak to a doctor if you're still experiencing these symptoms, as recommended by the other posters.

Went to a doctor this morning. She had NO idea what serotonin syndrome was so she had to go consult another doctor. She then proceeded to suggest i take anti-anxiety medication. Why would i want to put MORE pills in my body? I said to her, "I don't want to put a bandaid over the problem" The doctor then said that I was "smart" for saying that. WTF?!?!

She told me if i was still puking by monday that I should come back. Literally offered no help to me.

 

[adam west]

thats ridiculous if a dr doesnt know what ss is. doesnt the hyperthermia kill by severe ss? but then it aint just a case of serotonin syndrome at one level, where as you could have done some kinf of damage but not life threatening.

 

[Microload]

thats ridiculous if a dr doesnt know what ss is. doesnt the hyperthermia kill by severe ss? but then it aint just a case of serotonin syndrome at one level, where as you could have done some kinf of damage but not life threatening.

I don't believe I'm in any sort of danger of dying right now. The night I had the SS episode was the worst of it. And I think now that I made it past that I shouldn't be at risk of dying.

But I'm constantly puking, have bad diarrhea, blurry vision, headache, and extreme depression.

I am a straight A student with a LOT of passion for life and career. But this past week I literally don't care about ANYTHING. I am not a person. I don't feel like me and it's scaring the shit out of me.

 

[adam west]

i bet. i know its gonna sound a bit cliche but the best thing is probably just rest as best you can, keep hydrated eat as healthily as you can and try to avoid any foods that have possible maoi interactions.

ive sort of been in the same situtation as you nefore all though perhaps not as bad and i thought i had seriously done something bad. i didnt do anything for a few months after including alcohol. it took about 2 weeks for me to get back to somewhat normality.

edit: it also wouldnt be a bad idea to go to another dr for a second opinion if it will give you some sort of peace of mind.

 

[Venrak]

^Listen to the above.

The acute symptoms of SS have passed, which is fucked up if you think about it. But what I am trying to say is that you are not dying.

 

[Toucan]

I won't speculate about whether or not you suffered SS, though if you're not on any medication it does seem a little unlikely. In any case I think we can safely assume it's passed now.
Anyway, depression for a week or so after MDMA is a very common side effect of e. Some people get it much worse than others and since it's your first time with MDMA this could well just be your normal reaction to the drug.
It usually clears up within two weeks, but if you're still not feeling right then go see your doctor about it.

Oh and welcome to bluelight!

 

[Microload]

I won't speculate about whether or not you suffered SS, though if you're not on any medication it does seem a little unlikely. In any case I think we can safely assume it's passed now.
Anyway, depression for a week or so after MDMA is a very common side effect of e. Some people get it much worse than others and since it's your first time with MDMA this could well just be your normal reaction to the drug.
It usually clears up within two weeks, but if you're still not feeling right then go see your doctor about it.

Oh and welcome to bluelight!

I believe the 5-htp had a bad interaction with the MDMA. It produced way too much serotonin. I've read other accounts of 5htp+MDMA causing SS.

But yes, thanks for the help everyone. I guess my only choice is to wait it out at this point. The weird part is, the puking and mood have not gotten better even 1%. I would assume I would feel slightly better in the gut and mind area. But I don't.

 

[Toucan]

accounts perhaps, but serotonin syndrome is self-diagnosed on drug forums so frequently. you'd think it was contageous - I'm a bit skeptical.
It should reassure you that there haven't been any documented cases of serotonin syndrome associated with 5-htp so far. (according to this paper)
Anyway like people said above eat healthy, get plenty of sleep and exercise and wait it out. Keep us posted about how you're getting on

 

[Microload]

accounts perhaps, but serotonin syndrome is self-diagnosed on drug forums so frequently. you'd think it was contageous - I'm a bit skeptical.
It should reassure you that there haven't been any documented cases of serotonin syndrome associated with 5-htp so far. (according to this paper)
Anyway like people said above eat healthy, get plenty of sleep and exercise and wait it out. Keep us posted about how you're getting on

Would you happen to have a link to the actual paper? It says I need to pay for it.

 

[Toucan]

Thought it was in the abstract sorry, I have institutional access to it from my university.
it says this though:
In the case of 5-HTP, a similar syndrome has been reported in dogs that accidentally ingested and overdosed on their owners’ 5-HTP [49]. In humans, 5-HTP has been administered in combination with SSRIs and tricyclic antidepressants [50] (including the nonselective serotonin reuptake inhibitor clomipramine [51]), MAOIs [52], [53] and [54] and tryptophan [55]. To our knowledge, however, serotonin syndrome has not been reported in humans in association with 5-HTP, either as monotherapy or in combination with other medications.

 

[Venrak]

Thought it was in the abstract sorry, I have institutional access to it from my university.
it says this though:
In the case of 5-HTP, a similar syndrome has been reported in dogs that accidentally ingested and overdosed on their owners’ 5-HTP [49]. In humans, 5-HTP has been administered in combination with SSRIs and tricyclic antidepressants [50] (including the nonselective serotonin reuptake inhibitor clomipramine [51]), MAOIs [52], [53] and [54] and tryptophan [55]. To our knowledge, however, serotonin syndrome has not been reported in humans in association with 5-HTP, either as monotherapy or in combination with other medications.

MDMA is not considered medication in this context.

 

[Siccness909]

I agree with the MDMA and depression. Everytime I dose with MDMA I get BAD depression for the next couple days if not a good week. It seems like that's what your experiencing IMO. SS fuckin sucks..the first time I ever got SEVERE SS is still marked as the most frightening day in my entire life. I thought my body was permanently in fuckin OVERDRIVE and my heart was gonna explode I couldn't even walk...but yeah anyway I would just try resting as suggested above. Nothing much you can do aside from see a psychiatrist? Anyway hope you recover soon

 

[Black Rabbit of Inle]

But I'm constantly puking, have bad diarrhea, blurry vision, headache, and extreme depression.

The constant vomiting and diarrhea will contribute to the blurry vision and headache as you become dehydrated. I've always been told by doctors that if vomiting or diarrhea last for more the 5 days to get it checked out.

The fact that your doctor had no idea about ss tell me that you need to see someone else and explain you symptoms. It may be as simple as taking a stool hardener and anti nausea medication for a couple of days.