http://www.ecstasydata.org/view.php?id=2060#
These were my last batch, the ones I had that got me where I am.
The testing wasn't done until after the fact, but sure enough you can see they are pure MDMA.
The first line of defense is always to suggest that adulterants are responsible....
Why can't we all just accept that MDMA is neurotoxic and roll from there?
245mg x 2 tabs in one night = 490mg
By most of BL standards this is WAY too much.
Many do it and live to roll again, but it is well known that anything over 250mg in a night is just overkill.
The proper dose according to Shulgin is 150mg, followed by up to another 75mg before the comedown begins.
Of course I took 490mg, two weekends in a row!
And then 120mg the next day!
With lots of probiotics in my intestines.
Followed by 100mg of benedryl....
Do you see how Serotonin Syndrome is truly possible?
Another way to look at this is by body weight.
Since I weighed about 75kg, the math is simple.
Each pill put me at 3.26mg/kg.
For the night I took 6.5mg/kg !!!
Actual required effective dose for new users?
1.5mg/kg
Typical neurotoxic dose used in rodent models?
10 - 20mg/kg x 4 doses (high metabolism requires very high doses)
Minimum neurotoxic dose known in primate studies?
5mg/kg x 2 doses repeated for four days.
Suspected neurotoxic dose in humans?
Lower than that found in primates.
Most researchers that are brazen enough to administer MDMA to current human users, a controversial group among scientists, will NOT go beyond 250mg for the majority of subjects.
I recall one study that allowed a few experienced users to approach 400mg.
It is pretty much agreed upon by the experts that anything approaching 5mg/kg is
likely to be neurotoxic in humans.
Should such a dose be repeated the next day, there is little doubt remaining. Even by the 'controversial' researchers.
This is the big problem with MDMA, its main toxic effect happens when serotonin is depleted by the first dose.
Since tryprophan hydrolase is permanently disabled by MDMA, no new serotonin is being created to replenish the massive wave leaving the SERT.
Next the local-antioxidant supply is used up.
Metabolites of dopamine spill over into the serotonin transporter and destroy receptor sites.
Membranes open up and release mitochondria, which is a
highly alkaline substance.
Finally lipid peroxidation occurs - which is a nice way of the saying the fat that makes up your brain turns into hydrogen peroxide!
This is the primary theory of MDMA toxicity.
And a KEY component of this process is the depletion of serotonin by the first dose.
Any subsequent doses are in the position to cause much greater damage than the first.
And for some reason dosing on consecutive days seems to be WORSE than re-dosing on the same night (within reason).
Now how quickly a person gets depleted by the first dose may be highly variable.
Men have more serotonin than women, and research confirms that females are more likely to suffer the cognitive decline seen among heavy users.
But beyond this, there is a natural variation genetically.
Certain people may indeed have more reserves, but how can this be tested?
Cannabis increases serotonin temporarily, which is why it brings a fading roll back big time.
But long-term cannabis use may actually DROP serotonin levels.
Which would explain why heavy smokers are more often seen in the psychiatric studies follow a year or two of MDMA.
Cannabis is not just a 'confounding factor', many authors have labeled it a
primary co-factor.
Tryptophan Hydrolase takes 1-3 months to be restored following a single dose of MDMA.
This is the reason that spacing rolls is so critical.
If you don't wait until it has been replenished, then you are in a partially depleted state when you roll again!
Again, there is variation among the population.
Diet and exercise surely speed the process, but some people on BL seem to think that they can simply break the laws of biology.
By rolling multiple times in a month you are ignoring these simple truths.
Data cannot just be over-written by subjective experience.
And besides, what if some small form of neurotoxicity (including lipid peroxidation) must happen during EVERY roll?
What if the experience itself
depends on some small neurotoxic changes in the Prefrontal Cortex?
The significance of this may not be monumental, but each user should consider the possibility that this is how things are.
Block the neurotoxic dopamine influx into depleted cortical SERTs and the experience itself is blocked.
Or is it?
Whatever the case, dosage and spacing are VERY important.
Regardless of what some people on BL
seem to get away with.
Serotonin Syndrome is thankfully rare, but the data is pretty clear - repeat users go on to show modest cognitive deficits that do not resolve within 2.5 years of abstinence.
As always, longer tests are needed.
I'm a bit surprised I wanted to write at all tonight, so I must be feeling better already.
I hope this was an enjoyable and informative read for someone.
FBC
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