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BDD Moderators: Keif’ Richards
How many MG of Hydromorphone is a lethal dose
- Thread starter rc3mil
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HCandKROD
Bluelighter
That is a way too subjective question. If you don't know your limit please don't do opiates/opioids. Please be careful. I don't think anyone can answer your question responsibly. Good luck and stay safe. No medical advice here.
Dagda Mochta
Bluelighter
If you felt good from 8 mg you shouldn't go any higher. Once you've got any kind of opioid tolerance going on its realy hard to say how much is too much because the standard ld50 no longer applies. Also, pushing your doses higher is is going to make your tolerance build faster, which is a really good way to develop a full blown addiction. You should use the lowest possible dose that will get you off. If you get to the point where you NEED to increase your dose, I would only increase it by 2 mg at a time. Be careful.
Siccness909
Bluelighter
Man I snorted 16 mgs way back in the day and was opiate naive no tolerance. I felt fuckin AMAZING..was probably lucky though. Just depends on your tolerance.
hydroazuanacaine
Bluelight Crew
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- 8,492
it does't just have to do with your tolerance; bioavailability for hydromorphone varies greatly from person to person. and from ROA to ROA for each person. there are people who use the same amount of oxycodone as, me but 3 times as much hydromorphone. i take 30-40mg of hydrocodone (oral), but would never take 8mgs (plugged) of dilly at once. there are people who use the same amount of xanax as me, but half as much valium. conversions from drug to drug and from person to person work far from perfect--specifically for hydromorphone because of how significantly bioavailability factors. like above posters said, don't go above what works. though i say you should not abuse any hydromorphone because it is illegal.
exactly. same from me. i do not know and am not suggesting you take anything.
thesameoldfears
Bluelighter
If 8mg felt good why would you want to do more? 35mg of hydrocodone is hardly anything so please be careful.
filthygerms
Bluelighter
- Joined
- Jan 16, 2011
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- 78
This is an excellent point; however, im guessing since hes using hyrdomorphone, and looking for 1d50 information, that he is iving the shit and looking for an iv mdma like rush.
Dont go over that 8mg is your shooting, pal.......
12-16mgs is very very dangerous to iv...
Approximate Lethal Dose: oral: 500 mg/kg (female rat)
Approximate Lethal Dose: oral: 175 mg/kg (female rabbit)
Source:http://www.purduepharma.com/msdss/Dilaudid_1_2_4mg-mL_Injection_MSDS.pdf
Honestly this information is irrelevant anyways, it all depends on your tolerance which is dictated by your bio/neuro-chemistry. Instead of searching for the highest possible dose that can ingested before an overdose, practice responsible drug use by titrating your dosage up slowly from the one you're currently tolerant to. Just because you find yourself doing the amounts you currently do without consequences does not mean the same will apply if you increase your dosage by 30%,40%,50%, X% etc.
Approximate Lethal Dose: oral: 175 mg/kg (female rabbit)
Source:http://www.purduepharma.com/msdss/Dilaudid_1_2_4mg-mL_Injection_MSDS.pdf
Honestly this information is irrelevant anyways, it all depends on your tolerance which is dictated by your bio/neuro-chemistry. Instead of searching for the highest possible dose that can ingested before an overdose, practice responsible drug use by titrating your dosage up slowly from the one you're currently tolerant to. Just because you find yourself doing the amounts you currently do without consequences does not mean the same will apply if you increase your dosage by 30%,40%,50%, X% etc.
Dagda Mochta
Bluelighter
Chromo, I'm on my phone right now (and got massive eye wiggles from methylone lol) so I can't really go checkin facts at the moment, but are those numbers for real? 1/100th or even 1/500th of those doses would easily kill a human with just a slight tolerance, I know that much. Is there a decimal missing there? Rats and rabbits can't be THAT much different can they?
and @ filthy, OP said he was sniffing. U right though, IVing that amount would be a disaster if 8mg up the nose gets him off. Not to mention the addiction factor considerin the short duration of IV hydromorphone and the rapid impulse to redose. OP please don't go down that road. I speak from experience.
and @ filthy, OP said he was sniffing. U right though, IVing that amount would be a disaster if 8mg up the nose gets him off. Not to mention the addiction factor considerin the short duration of IV hydromorphone and the rapid impulse to redose. OP please don't go down that road. I speak from experience.
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BlueHues
Bluelighter
It's not really possible to answer this question for one....
For 2, I wouldn't feel comfortable dosing 200 mgs of hydromorph, but you also have to remember that there's a huge variation in bioavailibilty by ROA with this drug....dilaudid taken orally is pretty worthless IME...not that you should IV it....in some ways, I think Hydromorphone is a misleadingly overrated drug, but that's off topic...
Like somebody said, and like everybody always says, slowly increase the dose 2 mgs at a time leaving enough time between doses that the drug actually effects you before doing more, to be safe...
For 2, I wouldn't feel comfortable dosing 200 mgs of hydromorph, but you also have to remember that there's a huge variation in bioavailibilty by ROA with this drug....dilaudid taken orally is pretty worthless IME...not that you should IV it....in some ways, I think Hydromorphone is a misleadingly overrated drug, but that's off topic...
Like somebody said, and like everybody always says, slowly increase the dose 2 mgs at a time leaving enough time between doses that the drug actually effects you before doing more, to be safe...
Yes that's ripped straight from the Purdue website.
The ld50 test is becoming more and more obsolete because tests done on animals, as apparent in the study above, are sometimes completely inapplicable to human beings. A chemical maybe particularly harmful to humans, but that doesn't always extend to animals, and a substance maybe particularly harmful to animals, but that doesn't always extend either. This is due to a difference in biological factors between humans and other organisms.
Another classic example would be the ld50 of dextroamphetamine in rats, which is about 100mg/kg.
Dagda Mochta
Bluelighter
Yea that's crazy. I know rabbits have extremely fast metabolism, but that's still some absurd numbers. Not to b applied to humans at all. Obsolete is putting it lightly IMO lol. BTW I didn't know ur a mod now. Good shit man. I've always liked your posts and admire the way that you present yourself. Intelligent, genuine, and not cocky. Keep it up
^ Thanks for the kind thoughts! Likewise.
Obsolete is definitely an understatement, IIRC the national institute of health issued a statement several years ago strongly discouraging the use of ld50 tests. There's new tests under development as we speak which can translate to humans and promise to deliver more precision and accuracy.
Obsolete is definitely an understatement, IIRC the national institute of health issued a statement several years ago strongly discouraging the use of ld50 tests. There's new tests under development as we speak which can translate to humans and promise to deliver more precision and accuracy.
Dagda Mochta
Bluelighter
That's cool. U have any links to such research? I'd be really interested to learn how they're going about that.
pally pete
Bluelighter
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- Feb 21, 2010
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- 2,428
About time.
http://www.neavs.org/alternatives/in-testing
This one is in much more detail.
A lot toxicologists are attempting to invent the test that will be next in line.
Dagda Mochta
Bluelighter
Awesome. Thanks.
BlueHues
Bluelighter
You're a ringer!
Definitely in the medical field or studying medicine, or working in medicine in some capacity already, although you have enough time on your hands to post on here all the time, so IDK....
If you're just some random person that's pulling all of this off web searches, that would be evn more impressive, because you genuinely know the correct terminology...
There's a lot of people on here who seem to THINK they have a degree in chemistry, biology, pharmacology etc. but some actually do, which are you? You don't have to answer I'm just bored....
As for me, I just go off what I've picked up on and read and seen in life etc...but anyway...
Doctorate from the University of Bluelight actually, Harvard Medical School eat my dust!
For the ones that think they do, they may just have it. Sometimes a pharmacologist can know more than a doctor, and a chemist more than a biologist etc. It all depends on the individual, their intelligence and/or capacity to learn. Some doctors coast through medical school, while the pharmacologist is learning his ass off vice-versa.
For the ones that think they do, they may just have it. Sometimes a pharmacologist can know more than a doctor, and a chemist more than a biologist etc. It all depends on the individual, their intelligence and/or capacity to learn. Some doctors coast through medical school, while the pharmacologist is learning his ass off vice-versa.
hatrix
Bluelighter
Hey if a person has a degree in a field, congrats to them, but all that matters is if you really know your shit
BL doesn't require a degree haha, so us with knowledge can spread it, regardless of a degree. I'm personally still going for a degree in Biochemistry. I do like to see people with degrees on here, but who knows if they are lying or not unfortunately.
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