• MDMA &
    Empathogenic
    Drugs

    Welcome Guest!
  • MDMA Moderators: Esperighanto

Confirming risky MDMA usage and the resulting consequences

blight12

Bluelighter
Joined
Jan 28, 2012
Messages
1,628
Long post warning. I tried to provide enough detail of anything that might be necessary to answer the somewhat difficult to confirm questions at the end. Im really hoping for some answers therefore this is not posted in trip reports. Please dont move there if at all possible. I dont get a good response there.

I have lately been analyzing some of my history regarding the drastic MDMA related impact to my mental health and the years of problems afterwards as i need to keep an eye on some other younger persons I know using at this time and would like some final clarity for use as advice for others.

Background

Its been 8 years and i never really researched or looked into MDMA again or the problems it caused since it was a tough time and a tough 8 years. Didnt want to think about it and was scared to read what i might have done to myself. I became much better very fast recently. All i cant think of is that my brain has finally healed. Dont know if thats true or possible.

I want to understand what i did wrong and what contributed the most to my issues due to the potential risk or danger of the below two bad habits or others I am not aware of. I will give some background and then my specific questions are at the end.

Background - My two risky MDMA usage habits

1. I would use Friday and Sat night each week for just less then a year. Two consecutive days each week. I know consecutive day MDMA use is very bad so thats my first candidate for the resulting issues. Always on two days, never more.

2. Secondly I would take high doses, essentially taking enough over the night until I would transition into a stage, across about 7 hours, where it stopped working in terms of the emotional Serotonin effects and become a weird speedy trippy high with heavy visual activity such as significant peripheral hallucinations of objects morphing into other things, or seeing people on the dance floor who didnt exist when looking directly at them (also corner of the eye stuff) or seeing tiny objects like bugs buzzing around everywhere like the corners of the roof inside houses. It never felt unpleasant at anytime however.

I know pressed pills can have any dosage so the QTY doesnt really help to mention but just for completness the above was usually about 4-5 of what where supposedly good pills each fri and sat night across 7 hours that night for about 7-8 months.

It all finally ended after one weekend of using heavily the Friday night and then again the sat night, as I usually did.

Experience - The final two days of MDMA usage, Friday and Sat night

This time i noticed that when the Sat night dose kicked in it had an opposing effect, it suddenly left me feeling odd, like a sobering stillness came over me and my surroundings and i felt just average, in the middle, neither good nor bad, just dulled emotionally like i couldn't be bothered if i was out where i was or at home.

It didn't matter either way. Not to unpleasant and somewhat similar to the neutral calm, indifference or apathetic contentment you get the next day, as the mdma version of a hangover, which was also never very unpleasant for me. It was just "bleh" or "whatever" if that makes sense.

Experience - The following Monday afternoon and that night

I then ended up suffering the hectic brain zap thing the Monday from about lunch time which is commonly known and it felt like i would fell unconscious or loose my awareness completely for like a second or two after i get zapped. It was not pleasant. That night trying to fall asleep with brain zaps was the worst.

When lying there that night with eyes closed trying to sleep i would experience strong and distracting/disturbing CEV's manifesting as bring flashing lights that looked like blue and red pulsing police lights. It was so bright and blinding in my minds "eyes" and very unpleasant like trying to sleep with eyes open staring into bright lights.

Then the brain zap would hit every 5 minutes or so but mostly felt like it would hit at the point where you would fall asleep. When it hit it would cause a jarring and loud traumatic mental shock followed by fear and terror for a few seconds and my body would jerk awake violently.

It was similar to those nights where you have bad sleep paralysis that always reoccurs each time you eventually hit the point where you would be relaxed enough and fall asleep.

Except there was no dreamlike feeling of paralysis you cant awake from, it would just be an instant extremely loud zap/bang/crash with violent fearful awakening with lingering terror. It was extremely terrifying lying there not wanting to sleep knowing its going to attack you at your most vulnerable point if you do. I eventually fell asleep at some point.

Experience - The next day - Tuesday to Friday - derealization/depersonalization

I woke Tuesday into true derealization/depersonalization for i think 2-3 days of pure hell with zero emotion feeling like a robot and being able to look at my life and simply not caring about it, looking at loved ones and not caring if they died right in front of me, because i didnt know them, i didnt care either way.

The feeling was exactly like i was suddenly in somebody elses body or in a game where i had their memories but none of the emotional attachment. Logically from memory i know this is my room and thats my mother and i need to act in an appropriate way based on my memories, simply playing the part but without any care or feeling for any of it. Like in a game where you play a part but could mess around or not care since you can just quit at some point since none of it is real anyway.

Whats interesting is my memory of that time is somehow colored by the lack of any emotion. I can remember looking around my bedroom, at family members, surroundings while driving and being at work at it all looks different in my memory then other memories. It hard to explain but it looks alien, gray, ominous, dark, like there are subtle features overlaid across everything that you cant exactly identify, like how a scene in a horry movie like a haunted house looks evil but you cant tell why exactly at all since at face value its just a normal house.

Experience - The next 8 years

I was ok by the next weekend but after the experience above i never touched it again and then the bad anxiety, ptsd from another event and paranoia kicked in a few months later.

On the level of spending hours and nights just staring out of the window waiting for somebody to come break in and kill me or going to the mall and thinking everybody was somehow a threat or investigating every single creak or sound or dog bark, day and night.

Self medicated with a bottle of wiskey each day to help which made things worse and eventually became stable and functional after seeking medical help through Paxil which really helped with quality of life over the 8 years, mostly preventing the obsessive aspects and the ability to push down and forget the bad thoughts and feelings.

Now within the last year the actual fear has drastically improved even when thinking about it, along with the ability of logical thinking and reasoning allowing mitigation of unlikely dangers and helping to stop much of the paranoia and anxiety. I feel pretty much normal. It was a drastic change without any possible reasons or changes in meds or life and i heard somewhere that the brain eventually heals after 7 years or so. Cant confirm.

My questions based on the above info

1. Which habit above, consecutive day usage or the very high dosage per session was likely the biggest contributor to the consequences. Yes of course both combined is the obvious answer but lets say you only did one of them, which might be the most risky: Safe fri and sat night doses every week or only one very high dose once a week like I described. If both are bad, whats the worst? To help the others i mentioned it would help to know where to start focusing on in terms of safe usage.

2. I would like to hear from anybody who has used each friday and sat night for 7 months or longer and if this caused any issues.

3. I would like to try understand my dosage or state as described above for each night. In terms of taking the dosages mentioned and the effects described.
For example was this OD level, near OD levels, toxic dosages, some sort SS etc.
I would like an idea of what was going in inside my brain when you dose to this point, when the emotional aspects stop presenting and its mostly only speedy. Do others do this, sometimes or regularly and is it relatively safe or not.

I did this without issues until that final weekend, neither was the hangover to bad, it was mostly apathetic contentment, and never did my high doses make me feel ill or in danger/unhealthy during. I also cant rem ever really being effected badly by the comedown. I would always drink a reasonable amount each night from a little before and throughout the session, prob 8 beers or so. I think this always helped with comedown and sleep after.

4. I understand that the depletion and damage to Serotonin adds up over time and is not fully recovered after only 5-6 days. Does this mean the resulting destruction that last final weekend was a climax built from the very beginning due to ever depleting levels OR more likely due to my actions on that weekend alone.

I ask this because the Friday may have been the cause due from very high doses since i had a large volume (30 tabs) on me that night which i think i gave to many friends at a birthday party, and rem doing that with a few people, but i cant really remember most of the night. They where just all gone the next day, im sure i did alot but i didnt feel to bad the next day either until i dosed again that night.

5. How would a safe, sustainable regular MDMA usage schedule look.
For example: No more frequently then once every two weeks with no more then XXX mg of "pure" crystal mdma dosed no more then XXX times that night across no more then XXX hours. I believe the vital factors are days/weeks between sessions, dosage per session or per day, the number of re doses within that session and the duration of the session. Is that correct?

A long post so thank you for your time and any feedback. I know we cant confirm or ensure facts on the above queries, i dont need confirmed answers at all, but simply your own educated opinions or conclusions from your own experiences would be appreciated.
Any other feedback and info on where it might have all gone so wrong so suddenly would also help.

Cheers.
 
I'm not experienced enough to give you any advice on that, but I'm coming down from a roll and that's scaring the shit out of me. 8o
 
I'm coming down from a roll and that's scaring the shit out of me.

It shouldn't. He abused it solidly for a year with stupidly high doses each night. MDMA is a wonderful and relatively safe drug provided you use it sparingly. Its stories like this that the Daily Mail jump on, and shout "MDMA causes man 8 years of brain damage!!". Actually what happened is: Man tried MDMA, liked it, and then proceeded to eat the stuff like sweets for the next year twice a week. I'm glad your better, but can everyone please remember that MDMA is a brilliant tool not to be abused.
 
Some thoughts:

1) If it were me and I had to choose which would be less harmful, I'd take one big dose a week over two normal doses on back-to-back days. As you know, MDMA depletes the serotonin in the brain, and once you've taken enough to deplete it, taking more won't actually do anything. On the other hand, dosing two days in a row means another full day of no serotonin.

2) It's also possible that your last pills were bad (not MDMA... and yes, even if you got them from the same source and they looked the same as always).

3) It sounds like (and you explicitly said) you have other issues. People that are happy people don't (usually) abuse drugs like you did, and the continuing symptoms are not necessarily related to the MDMA. Perhaps just count yourself lucky that you attributed your issues to your drug abuse and stopped before you further damaged your brain.
 
+
It shouldn't. He abused it solidly for a year with stupidly high doses each night. MDMA is a wonderful and relatively safe drug provided you use it sparingly. Its stories like this that the Daily Mail jump on, and shout "MDMA causes man 8 years of brain damage!!". Actually what happened is: Man tried MDMA, liked it, and then proceeded to eat the stuff like sweets for the next year twice a week. I'm glad your better, but can everyone please remember that MDMA is a brilliant tool not to be abused.

Yeah. I dont want to freak anybody out and i hope readers take note of the irresponsible usage information that explains the issues so you dont get all paranoid for no reason. It can be used safely and responsibly but unfortunately it usually takes a fuckup that can cause long term issues before users catch a wake up, treat use seriously and research everything related to their usage.

I was young and stupid but now im thankful for it from all the shit it taught me. Hopefully others can learn from BL and other members experiences and avoid making the mistake themselves.

The problem as well for the uninformed is that MDMA, at least where i come from has this friendly non threatening reputation resulting in people easily abusing it.

In my personal experience however it did more damage in less then a year then the following 8 years of more frequent coke and more recently meth use. Coke over those 8 years did prob 1% of the damage MDMA did in that year. IF you dont treat it with respect.

Its just so easy for young people having fun and taking risks to cross the line into long term issues territory. The solution is simple education so everybody here is certinally on the right track. I wish i knew about this place before i began.

I dont want to be negative about MDMA, its still my first love and one day I will be off my SSRI's and will experience it again. Its my deam. I am still positive about it and consider all the consequences my own silly mistake. Like any tool, it can be used for good or for evil.
 
Some thoughts:

1) If it were me and I had to choose which would be less harmful, I'd take one big dose a week over two normal doses on back-to-back days. As you know, MDMA depletes the serotonin in the brain, and once you've taken enough to deplete it, taking more won't actually do anything. On the other hand, dosing two days in a row means another full day of no serotonin.

2) It's also possible that your last pills were bad (not MDMA... and yes, even if you got them from the same source and they looked the same as always).

3) It sounds like (and you explicitly said) you have other issues. People that are happy people don't (usually) abuse drugs like you did, and the continuing symptoms are not necessarily related to the MDMA. Perhaps just count yourself lucky that you attributed your issues to your drug abuse and stopped before you further damaged your brain.

The drug use in my case was not really due to being unhappy or wanting escape etc. I have always had a comfortable life but I learnt from a young age that i need to make my own mind up about things, question everything and not simply do or believe what im told.

Drugs, due to the common propaganda was an attractive way to exercise this value. From there i i just fell in love with MDMA and did as much and as often as i could simply because i was have such a great time every weekend. It was a great time for me until the issues began.

There are anxiety issues in the family, from my moms side. These where not manifesting until the above period was over. My psychiatrist mentioned an explanation about how bad anxiety issues can often be triggered when the combination of genetics and a life experience / health issues comes into play and combined they trigger the issues that follow.

In my specific situation the anxiety after the MDMA use was just moderate general anxiety for a while but unfortunately i experienced a very mild non violent armed robbery at home. That combined with genetics and the damage from the MDMA use triggered the serious obsessive life disrupting PTSD i suffered for the following years. This experience would not normally have done this to anybody else and my friend who was with me at the time was perfectly fine after this.
 
Taking really high doses and doing it in consecutive nights are kind of the same thing. After about 200 mgs or so I don't think there's much serotonin to release and then the next day it's the same thing. The only time I went overboard on dosage was my second time doing it also was the second night in a row. I ended up doing close to 600 mgs and it was a scary experience, that alone never made me dose high again, even though i've gotten to 350 mgs with no scary side effects like the other time. It's all bad so I think high doses and redosing you can't say ones worse they're both really bad.

As well without testing your stuff you have no clue what your getting. When I got good mdma and not those dodgy e pills I really didn't last doing mdma every week for awhile. As well you don't have a great idea of how much mdma was in each pill so dosage is unknown but I'd say 200-250 mgs is about as high you should go in a night. I'm not as experienced as some here but I abused it pretty heavily for two years and after all of it I'd say probably once every 4 months is the safest and take one does of around 140 then a 60 mg booster 45 mins later.
 
Wow, 4 months. That makes twice a week look like insanity. Makes sense. I would imagine users would find this very difficult, especially new ones. Its just to damn awesome. I think also the safer more frequent usage of other common rec drugs can give the impression that the same should be ok with MDMA for those uneducated on the risks. If only it was as user friendly as dopamine, life would be great.
 
Wow, 4 months. That makes twice a week look like insanity. Makes sense. I would imagine users would find this very difficult, especially new ones. Its just to damn awesome. I think also the safer more frequent usage of other common rec drugs can give the impression that the same should be ok with MDMA for those uneducated on the risks. If only it was as user friendly as dopamine, life would be great.

Once you abuse it so quickly and for a descent amount of time it isn't even that fun. I rolled on halloween it was alright, way too much jaw clench, got an orgasmic body high and felt amazing but the magic isn't there. Same thing with my last one new years, touch is still good but not outta this world and there isn't that ridiculous amount of love. I'm probably gonna take a whole year break and roll next new years or halloween. The depression after isn't worth it and it isn't that great anymore that's just it you abuse it and it's not as good not even close. I definitely have done some damage to my serotonin receptors.

I did shrooms twice since new years with alcohol and had a way better time than my last two rolls, and also had no side effects whatsoever. Who knows maybe I'll take the break and decide to never roll again, I've done enough for a lifetime anyways. Twice a week for 8 months is insane though, can't imagine how that musta felt like.
 
1. Both have there own way of causing excess neurotoxicity. Two regular doses on back to back days would be worse than a single large dose once, but you were doing both every week. "Safe usage" is to test your drugs, try to take no more than 250mg in a night, avoid redosing, and only use mdma once every 2 months.

2. not me

3. Acute, life threatening OD would be when you took enough to experience serotonin syndrome. This happens when someone either takes a super high dose(maybe approaching a gram of pure compound, maybe more, maybe less), or mixes mdma with another drug that boosts serotonin levels(ex: DXM or an MAOI). In your case, your regular usages meant that you probably wouldn't have had enough serotonin left to bring concentrations to lethal levels. And yes, this type of use is how you maximize toxicity(repeated dosing, frequent use, high doses). The "speedy" effects could be from adulterated drugs, but in sufficient doses, mdma can cause the same effects. Many people describe the effects of mdma when used like this to be similar to methamphetamine, but weaker. All the serotonin is gone but dopamine and norepinephrine is still being pumped out. The hallucinations were a condition called "amphetamine psychosis".

4. It can take several weeks, if not months, for serotonin levels to fully recover after a single use of mdma, surely longer in your case. The damage isn't simply lower levels of serotonin with it being depleted more and more each time. Once the serotonin is gone, you can't do much more damage in that regard. However, there is actually damage to the brain cells that does continue to accumulate with each dose. We are not completely sure how well the brain can repair this damage, although people do report the symptoms getting better with time.

5. For a healthy individual, Assuming you have truely "pure" mdma, which is quite rare, even if it isn't cut:
--80-100mg for a moderate to strong experience, 100-150mg for a very strong experience, 150-200mg for a heavy experience. (Note that for street quality mdma, doses will be slightly higher depending on purity. You may also have to adjust slightly for body mass, but not nearly to the extent as with alcohol.)
--Try to avoid redosing. If you must redose, do it within the first hour after taking the initial dose. Never redose after the first dose wears off.
--Wait two months between uses
--To reduce toxicity, take antioxidants, vitamin C, vitamin E, and/or COX inhibitors(naproxen, ibuprofen, aspirin, preferably naproxen as it lasts much longer) before and during the roll. There is a thread somewhere about supplements and toxicity.
 
^^ Great post thanks!

To respond to a few points:

1. OK, so it seems my doses where not OD level and the likely candidate for my issues is the weekly use and consecutive daily use (with the higher per session doses adding to this). Based on the rest of your post its clear my usage was unhealthy.

2. I currently engage in weekend methamp usage for about 9 months or so and based on my experience here i dont think this was involved in terms of an added adulterant in the pills. The amp psychosis and hallucinations i am familiar with is nothing like those experienced on the MDMA. The MDMA experiences where far more enjoyable and similar but much less "awesome" then MDA. I am sure these where from pure MDMA only.

Additionally the pills where sourced from personal friends of a friend who did the pressing and distro. Due to this and the cost price cheapness is probably also why i was an idiot and took to much. I agree this doesent prove anything but i feel only mdma was involved taking all things into account.

3. In terms of recovery, i only recently recovered drastically from these issues after about 8 years. Its like light and day now, im almost like i was before. I am actually struggling a bit due to being used to anxiety and fear. They are excellent motivators, i learnt to use them, even built my own business using it, and without them i feel very lazy and complacent without much purpose, even though i am far happier.

4. Two months between doses is interesting to finally have confirmed. I am sure this will not be naturally understood or followed for new and/or uneducated users. I wonder how many MDMA users who dont have access to a BL or another source for this info are dropping like flies due to assuming more frequent usage like other drugs is ok.

5. Due to the improvement of the issues i might taper off SSRI's soon. I would then like to carefully test MDMA again in a responsible manner. What is the time period between complete cessation of the SSRI Paxil and the point when MDMA would be effective again. I get conflicting info here.

6. Bonus question, just out of interest, what makes the difference between Serotonin drugs combos that result in one blocking the other, like SSRI's blocking MDMA compared to other drug combos that have a dangerous additive effect like DXM and MDMA. Whats the differentiating factor. Could you point me in the right direction to research?

Thanks for the feedback!
 
Talk to your doctor about tapering off the ssri's. Paxil(paroxetine) has a half-life of 24 hours. The standard procedure is to put a patient on Prozac(fluoxetine), which has a half-life of 4-5 days. The longer duration will allow you to taper more easily and reduce the withdrawal symptoms. How long it takes you to get off the drug depends on how long you have been taking it and at what dose. You may be able to roll again in a couple of months, but some people are never able to get the same effects after taking ssri's so just hope you get lucky.

You probably should stop the methamphetamine. It is also neurotoxic and also releases serotonin, though not as much as mdma.

MAOI's are so risky because they block the enzyme that is responsible for metabolizing a large number of neurotransmitters and drugs. When combined with mdma, all the serotonin that gets released has no way to get metabolized and quickly reaches lethal concentrations. With reuptake inhibitors,(dxm, antidepressants, etc.) its tricky. I'm not 100% sure of the effective differences between all of them as far as how they actually bind to the serotonin transporter. The studies I have read all involved the SRI being given BEFORE or AFTER the mdma and never at the same time
 
Thanks. An interesting positive effect of the MDMA issues i had was the deletion of cravings and other addiction related trappings common with stimulants. This suddenly happened later in the 8 years but it must be related. Its the reason why i can do coke or meth without the usual addictive obsession. It meant easy use of coke and now meth with less risk.

It is also appealing due to the zero damage i experience compared to the mdma usage. I think using coke for those 8 years impacted me about 1% compared to less then 1 year of MDMA use. Non MDMA stims seem to have no negative effect at all on existing anxiety issues. A worthy replacement in that respect i guess.
 
Dude you did a good job of articulating the derealization and depersonailisation feelings. I got these same feelings but used MDMA sparingly, (1-2) months in between usage for around 1 year and a half. I'd only do it at raves , and take no more than 3 in a night. So it doesn't take weekly abuse to get here guys, MDMA is a serious neurotoxin. Notice how he is doing meth and coke for so long and he says the damage doesn't even feel any where as bad as MDMA did in less than one year. I hate when people write it off as abuse, even with moderate use like mine you can still run into depersonilisation / derealization, anxiety and depression.

To the OP, i have been on SSRI's for a short while in the past and they are great at masking the bad / negative feelings but trust me. Tapering off the SSRI to use MDMA again is NOT a good idea. Even if you want to do it responsibly. I can put money down that once you completely get off the SSRI some depression and negative thoughts are going to start representing them self in your life again. And adding MDMA to that can send you back to your old self. It is not worth that 1 night of fun, MDMA will not make you realize anything for the long term it will not cure your depression or any of that non sense. All it will do is degenerate your serotonin system, You have been off MDMA for so long .Don't ruin it
 
Last edited:
1. Both are equally bad…if you did one or the other instead of both, you would have ended up the same way. It may have taken longer to reach your situation but it would have come just the same.

2. I abused every weekend for 2 years. Normally only on one day but sometimes two. First started taking only one pill a night and grew from there. My limit was normally 3 pills a night but there were a few times I took more.

3. This is common for all MDMA users. Your brain has a finite amount of serotonin to release. Once it is gone the emotional aspects fade and all that is left is the speedy effects. Since we are talking pills and not exact amounts we can only guess based on available data. 8 years ago pills were reported in the 80-120mg range so on any given night you were taking roughly 360-600mg of MDMA. The LD50 for humans with MDMA is thought to be 10-20mg/Kg. this means for a 200lbs man, taking 900-1800mg of MDMA would be fatal 50% of the time. So your dosage level was high but not “OD levels”. but there are many cases seen here on bluelight where people have taken more and survived. there just isn't enough info about how much MDMA it takes to kill a human to say accurately.

4. Your symptoms are the culmination of all your abuse. The high dose day was not the straw that broke the camel’s back it was just a coincidence that it happened then. It could have happened anytime at the usage level .

5. “completely safe” MDMA usage is a misnomer because there is always risk involved. But if you are sure you have pure MDMA ( it is really hard to be sure even with a test kit) the best plan to use for extended periods (many years) without ill effects is to take MDMA only 3-4 times a year. Use only a moderate dose (100-125mgs) with a booster of half the initial dose 45min to an hour after later if desired.

Following that schedule will allow most people to use MDMA for a very long time without incurring any negative side effects or building a tolerance to the drug.


Everything you said in your post happened to me…the only thing different is that I didn’t use 2 nights in a row and my recovery was much quicker and did not require professional help or meds.
 
Last edited:
1. Both are equally bad…if you did one or the other instead of both, you would have ended up the same way. It may have taken longer to reach your situation but it would have come just the same.

2. I abused every weekend for 2 years. Normally only on one day but sometimes two. First started taking only one pill a night and grew from there. My limit was normally 3 pills a night but there were a few times I took more.

3. This is common for all MDMA users. Your brain has a finite amount of serotonin to release. Once it is gone the emotional aspects fade and all that is left is the speedy effects. Since we are talking pills and not exact amounts we can only guess based on available data. 8 years ago pills were reported in the 80-120mg range so on any given night you were taking roughly 360-600mg of MDMA. The LD50 for humans with MDMA is thought to be 10-20mg/Kg. this means for a 200lbs man, taking 900-1800mg of MDMA would be fatal 50% of the time. So your dosage level was high but not “OD levels”. but there are many cases seen here on bluelight where people have taken more and survived. there just isn't enough info about how much MDMA it takes to kill a human to say accurately.

4. Your symptoms are the culmination of all your abuse. The high dose day was not the straw that broke the camel’s back it was just a coincidence that it happened then. It could have happened anytime at the usage level .

5. “completely safe” MDMA usage is a misnomer because there is always risk involved. But if you are sure you have pure MDMA ( it is really hard to be sure even with a test kit) the best plan to use for extended periods (many years) without ill effects is to take MDMA only 3-4 times a year. Use only a moderate dose (100-125mgs) with a booster of half the initial dose 45min to an hour after later if desired.

Following that schedule will allow most people to use MDMA for a very long time without incurring any negative side effects or building a tolerance to the drug.


Everything you said in your post happened to me…the only thing different is that I didn’t use 2 nights in a row and my recovery was much quicker and did not require professional help or meds.

Great info thanks! This confirms my thoughts overall.

I do wonder if the SSRI's delayed my healing overall, though i must say that probably would have been unavoidable as they where necessary to remain functional.

Lastly I would just like to query the 45 minute max redose. I heard this before and im really interested in what the basis around this is. Is it basically just to avoid extending the experience and the damage thats caused in this way specifically?

Cheers
 
^ The longer you wait to redose, the more serotonergic tolerance that is accrued. This causes higher release rates of dopamine, and consequently, dopaminergic free radicals that have been linked as a major source of MDMA related damage.


I couldn't find the actual study I was looking for, but this study: http://www.erowid.org/chemicals/mdma/mdma_neurotoxicity1.shtml
Early evidence that MDMA caused significant oxidative stress came from Stone (1989a) who reactivated TPH which had been inactivated in rats at 3 hours after high dose MDMA by using sulfhydryl reducing conditions. This showed that the acute inactivation of TPH by MDMA was due to intracellular oxidative stress. Intracellular oxidative stress appears to be an effect of MDMA that requires sustained brain concentrations of MDMA (or a centrally formed metabolite). While a single injection of MDMA into the brain had no effect on TPH activity, slow infusion of 1 mg/kg MDMA into the brain over 1 hr produced enough oxidative stress to acutely reduce TPH activity (Schmidt, 1988). The acute decrease in TPH activity is an early effect of MDMA and can be seen 15 minutes after administration (Stone, 1989b). TPH inactivation can also be produced by non-neurotoxic MDMA doses (Schmidt, 1988; Stone, 1989a; 1989b). It therefore appears that MDMA rapidly induces oxidative stress but only produces neurotoxicity when the brain's free radical scavenging systems become overwhelmed.

Which may indicate that MDMA's tolerance begins around 15 minutes in.. it's a good excerpt, regardless.
 
2. I would like to hear from anybody who has used each friday and sat night for 7 months or longer and if this caused any issues.

I was definitely doing the same thing as you for the same amount of time and I have so many issues. I have a ridiculously high tolerance- I could take 200mg with almost no effect ... One of the worst problems I've noticed is I've lost my libido which is insanely frustrating! also I can't seem to shake restless legs and of course all my emotional problems- anxiety, paranoia etc

I'm confused though, did you go 8 years of not touching it? Have you gone back to it?
 
^ At this time, two years ago, I was taking MDMA almost every Friday for a period longer than 6 months. For several months before and after this as well, I was still taking too much too often. It measures down to around 200 pills taken in that time.. some were amazing MDA pills, some awful piperazines. I'm just telling you this so you can understand... I used to (?) be an idiot.


After this, obviously I was ruined emotionally. I was severely depressed, often just wished my life would end. There was several points actually where I had held a loaded gun to my head with a finger on the trigger... again, just telling you this so you can understand how bad it actually was.

I thought I had ruined my life FOR EVER... luckily, I have come to realize this is not true in the slightest. I have made an almost 180 degree turn, and am EXPONENTIALLY better. It took about 8 months since my last pill to even BEGIN to feel this good again, but it happens.. trust me on that.




Now it just so happens, I'm planning a roll for next Friday! I've learned my lesson from the past though, MDMA is a drug that needs to be treated with the utmost respect... and I give her it. I'm lucky, I still have the "magic" even after such ridiculous abuse. It's not 100% of what it used to be, and neither am I... but it's OK. Life goes on, life goes on. :)
 
You do what you want folley, but if you really sit and think about it . With out any of the impulsive thoughts of telling you how good it will. You probably wouldn't want to roll, go find a less toxic drug man. Why kick your serotonin system back a few steps when you have come this far, just looking out not hating.
 
Top