MDMA DOSE & Serotonin FX

[neur0]

if you don't take enough mdma to actually roll face, like a typical dose people do... and smaller amounts, do you think it depletes less serotonin and is less harmful? (only enough to achieve a slight effect, not the "hug the world dance the night away" feeling)

...if that made sense lol

 

[Black Rabbit of Inle]

Taking smaller doses would release less serotonin into your brain. If it is less harmful would be subjective.

This thread may be better suited to ED.

EDIT: Moving this to ED

 

[Clocktower]

Yes, heavier doses generally cause more neurotoxicity and negative side effects than do lighter doses. Either way, keep at least a month between rolls and more if possible.

 

[Youngling]

^This. & Don't forget to test your stuff to make sure what you actually have is MDMA. You could be doing even more harm to yourself by ingesting something else.

 

[xx001]

Smaller doses will cause less serotonin to be released. Neurotoxicity would also be reduced because there would be less of the neurotoxic metabolites floating around and more serotonin to compete with them for the receptors.

 

[Darksidesam]

Ive taken just 90mg before and i barely noticed any side effects after, i didnt feel different or weird or funny,
I just felt positive. I felt lots of euphoria when i peaked considering the dose i took, this was back in october though.

If your taking a higher dose, get some anti-oxidants in ya afterwards, blueberry juice, green tea, vit c + e or a multivitamin , dont go overloading your body with vitamins tho if you've just got on it, don't want to strain your kidneys.

around the 150mg is where it gets a bit stronger for me and strong on the brain haha. (maybe not after being on them SSRI's , blocking my fun)

 

[severely etarded]

Smaller doses will cause less serotonin to be released. Neurotoxicity would also be reduced because there would be less of the neurotoxic metabolites floating around and more serotonin to compete with them for the receptors.

clearly you pulled this statement out of your ass....

 

[xx001]

clearly you pulled this statement out of your ass....

I did not pull it out of my ass, but I do realize now that my post was a bit unclear.

MDMA itself is not neurotoxic, however, some of its secondary metabolites are. Specifically, alpha-methyldopamine, N-methyl-alpha-methyldopamine, and 2,5-bis(glutathion-S-yl)-alpha-methyldopamine are the prime suspects here. The damage is done to serotonergic neurons after the mdma is metabolized and we are left with the aforementioned compounds floating around in the synapse. With higher doses of mdma, there will obviously be greater concentrations of these harmful metabolites. Also, when the drug wears off, serotonin levels are significantly lower than normal(the crash). With less serotonin in the synapse, the metabolites have less competition for the associated receptors and serotonin transporter. These metabolites then cause their damage by exerting oxidative stress to the receptors and SERT, resulting in cell death.

With a lower dose, there will be a smaller initial release of serotonin and, therefore, more leftover after the drug wears off. This will leave a lower concentration of neurotoxic metabolites and a higher concentration of serotonin. As a result, the damage will be less than if the user took a higher dose of mdma.

Read more here: http://www.bluelight.ru/vb/threads/598956-The-Brain-Damage-of-MDMA-(-quot-Ecstasy-quot-)

 

[severely etarded]

the damage will be less than if the user took a higher dose of mdma.

^^ just wanted to summarize that paragraph in lamens terms.. You know, for the majority of folks who aren't neuro scientists with PhD's and whatnot