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  • BDD Moderators: Keif’ Richards

Hydroxyzine vs Promethazine

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THE_REAL_OBLIVION

THE_REAL_OBLIVION

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I know these are the top 2 available antihistamines out there, but they don't knock me out, just make me able to nod on my dose of methadone! which in itself is pretty good after a hard day in college (doin' a masters now at ~30 , don't care if i'm older than most there, it used to before i discovered opiates which destroyed my fear of going out, fear of people etc).

Unfortunately my methadone doc has changed an atarax(hydroxy) script of 50mg (the red little balls that gummy) twice at bedtime to only 20 a week of a take 25mg every 6 hours. So I'm a bit annoyed but not too much. Promethazine is legally sold OTC in canada! I would think otc promethazine more useful than the lame tylenol #1's we can also get there, and I won't talk about the cough syrup lol.

But it seems promethazine does not make me all that much more noddy. I definitely feel its effects and feel, somehow cloudier. So to me hydroxyzine is almost the only worthwhile potentiator, by experience and from reading a lot about it.

There's also this antihistamine that people would shoot pentazocine with... it's the blues in the talwins and blues i think
 
I don't think we allows these threads....


But promethazine is more sedating for me, hydroxyzine has better anxiolysis.

I like them both
 
If the question is just what are the differences between promethazine and hydroxyzine I don't see how that's not allowed?

THE_REAL_OBLIVION said:
Promethazine is legally sold OTC in canada! I would think otc promethazine more useful than the lame tylenol #1's we can also get there, and I won't talk about the cough syrup lol.

But it seems promethazine does not make me all that much more noddy. I definitely feel its effects and feel, somehow cloudier.
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Wait, what? Are you saying that you are now currently prescribed promethazine and you have actually picked it up from the pharmacy? And/or you have recently been able to get it OTC? My pharmacist told me that promethazine was completely discontinued in Canada a few months ago.
 
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<snip - not relevant> im currently on [promethazine]. I found that when i first used it about 2 years ago it was great for sleep okayish for anxiety and decent opiate potenator.But the last couple of months its effects have somewhat diminished.Most likely down to tolerance but i dont use it daily who knows.I would be very keen to try Hydroxyzine though!!!!!
 
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Hydroxyzine any day of the week for me. Promethazine feels a lot like an anti-psychotic with pretty pronounced anti-cholinergic effects.
 
I have removed posts about how to get drugs from your doctor and the legal status of drugs in countries other than the OP's. I feel partly to blame for the direction this thread has taken because I asked if promethazine was actually currently still available in Canada. I felt this was relevant to the thread since if it is true that - as I was told by more than one pharmacist - it was discontinued in Canada that would remove it as a choice for the OP (and of course I'd like to know as well). Can we please stick to discussing the differences between hydroxyzine and promethazine. Thanks.
 
My GP wasn't even aware of the 50mg red ones. Had to tell him. Psychiatrists sometimes script atarax for sleep and anxiety as an adjunct medication to benzos (have the patient take less).

I preloaded with 100mg of promethazine and went to pick up my dose 1h30 later. <snip: not relevant or in the interest of harm reduction>

Swimmingdancer said:
If the question is just what are the differences between promethazine and hydroxyzine I don't see how that's not allowed?



Wait, what? Are you saying that you are now currently prescribed promethazine and you have actually picked it up from the pharmacy? And/or you have recently been able to get it OTC? My pharmacist told me that promethazine was completely discontinued in Canada a few months ago.
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Nope they haven't. They have discontinued the 25mg orangey-rosish Histantils (OTC promethazine) only. Very few chains actually carry the stuff but my pharmacists are more than happy to sell me the royal blue 50mg pills with a PMS imprint (Pharmascience, a pretty common generics company here). She might not be aware it is still OTC because i only know of 1 chain that has it behind the counter here.

MikeRWK said:
I was told its not otc in my province, and Talwins are not the T in Ts and blues, also talwins suck ass.
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Maybe the american talwin, canadian Talwin is awesome and doesn't have naloxone in it. I enjoyed them pentazocine 50mgs a lot when I was able to get em a long while ago
 
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THE_REAL_OBLIVION said:
Nope they haven't. They have discontinued the 25mg orangey-rosish Histantils (OTC promethazine) only. Very few chains actually carry the stuff but my pharmacists are more than happy to sell me the royal blue 50mg pills with a PMS imprint (Pharmascience, a pretty common generics company here). She might not be aware it is still OTC because i only know of 1 chain that has it behind the counter here.
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Ah, perhaps only the prescription promethazine has been completely discontinued by the manufacturer and the pharmacies I checked were just unaware that there was an OTC promethazine.

I haven't had the opportunity to try it yet due to that, so I'm sorry I can't comment from personal experience on your question but from a pharmacological standpoint I can tell you a bit about the differences between promethazine and hydroxyzine. The main difference is that promethazine has much more pronounced anticholinergic effects. This can cause side effects like dry mouth and throat, raised temperature, sensitivity to light, blurred vision, increased heart rate, restlessness, urinary retention/constipation, shaking, difficulty concentrating, and even hallucinations and delirium if you take too much. So you want to be careful with the dose.

In general less is more with either of these drugs, since higher doses will have more SSRI effects and more dopamine blocking effects than lower doses, where you will just get the antihistamine effects with lower doses (sedation etc).
 
Haha. That read like a lecture you'd keep for..ahem..those of a lesser intellect who del out on benadryl. I take 150mg (spread over the day) of promethazine when I have it, nothing alarming.

So people in theory could trip out from promethazine, interesting. I don't think atarax does anything like this for sure cos i've had the red gummies that have 50mg in them very often). I also like it better when I wake up when I have atarax, while waking up from a day of potentiating methadone with prometh is often very cloudish and unpleasant.
 
I have yet to find promethazine OTC here in or even in Ontario when i was up there. In fact only 1 pharmacist i know has even heard of it and he hasn't seen it in ages. According to the drug product database promethazine is still available OTC in Canada as Histantil tabs and pharmascience brand promethazine syrup. But again i don't even know anyone that has managed to find a pharmacy that stocks it. Promethazine for injection is in the ethical category like ampules and vials of dimenhydrinate and diphenhydramine are which means that if the pharmacist really wanted to he could give it to you. I would love to try it with morphine as Ive heard the combo it rather good.

I find hydroxyzine to be really good and another one worth mentioning is doxylamine. Oh and the anti-histamine that was in the T's and blues combo was Tripelennamine. I have no idea if you can get that anti-histamine anywhere anymore and Talwin these days is very rare as well so i think that combo stopped being popular around the early 90's or so. I would also ,like to try cyclizine as Ive heard really good things about it as a opioid potentiator but that's another one you can't get in Canada as far as i can tell.
 
Ive had Promethazine syrup with codeine before, actually a whole bottle taking small gulps each time & it did get me high & is a great mix with vicodin, etc........but it is also sedative as well. Its great at night when you need some sleep. Havent tried Hydroxyzine tho so I cant compare...........
 
THE_REAL_OBLIVION said:
Haha. That read like a lecture you'd keep for..ahem..those of a lesser intellect who del out on benadryl.
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Not really, some people are sensitive to these side effects even in moderate doses and a lot of people assume more is better when using antihistamines for things like sedation, anxiety and potentiation of opioids, not just people who are trying to get high off them. Also many people are not aware that "antihistamines" have more effects than just being an antihistamine. That doesn't make them of a lesser intellect (although I assume you were referring to people taking huge doses in an effort to get high).

*Also just a reminder to everyone, if we can please stick to discussing the differences between these drugs and not get into where to get them, how hard they are to find OTC, what pharmacies have them, etc. We've established that they are still available in Canada OTC, in some places at least, while the prescription form has been discontinued, can we please move on from that now, thanks. BDD is not about helping each other find drugs.
 
I liked hydrox more than prometh. prometh just makes me sleep. since you're on the 'done, ever think of trying cyclizine? apparently it was all the rage in the UK.
 
Well, PA knows what chain I get it from but apparently I couldn't say it here. Stupid me, i'm a member here since almost a decade, should've known better and I experienced a lot lately and just 25mg of hydroxyzine > 50mg promethazine to me. Hydroxyzine makes me feel my methadone nicely, not too hard, but i dont fall down from sedation 30 mins after I take it unlike prometh at any dosage higher than 25mg. But those Histantils were discontinued and the 50mg ones are not scored to split in 2.

I don't think cyclizine is available here...maybe it is with prescription. What was that site you have Paranoid Android to verify the status of medication in canada ?
 
The cyclazine antihistamines (WHICH CROSS THE BBB, AT LEAST...I'M LOOKING AT YOU, CETIRIZINE) do a PHENOMENAL job of potentiating methadone and similar non-traditional opioids.

If you have *codones or *morphones, go for promethazine. If it's methadone, LAAM (do you guys still have that in canada?) pentazocine, mepiridine, etc you're going to definitely want hydroxyzine.

Diphenhydramine is decent for both.
 
cyclizine shouldn't be scheduled so you may be able to source it online. also I heard children's dramamine contains cyclizine too.
 
I'm really really surprised promethazine isn't an rx thing anymore. Sure a doctor could rx it to you like they can script you tylenol but geez, if someone doesn't have a file at that particular chain in Qc that has Histantil 50mg pills and I guess the liquid too, they're gonna have a rough time.

Promethazine is one of the first medication I was ever prescribed when I was old enough to go to the hospital/mini-ER on my own. I was telling the doc I was lacking sleep and feeling aggressive because of the lack of sleep. Then I pick up my rx and dial that 56 motherfucking K up to usenet and browse a bit (on altavista probably :D ) and I was finding information about it being an antipsychotic and was really puzzled why I was given that instead of valium or something else. haha, when i was 18 I was still pretty naive about drugs. Oh shit how things have changed. So much that promethazine is hard to find for most of my fellow citizens.
 
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