Opioids Fat and Codeine
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Thomas29
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Wtf does that even mean how else would one take Codeine I say again WTF lol?
Jabberwocky
Frumious Bandersnatch
Umm.. Codeine is contained in a lot of products beside t3s. Ignorance is bliss.
Yes, but any meal with codeine will prolong the high to a certain extent. A high fat meal does not alter the bioavailability of codeine in itself no.
Yes, but any meal with codeine will prolong the high to a certain extent. A high fat meal does not alter the bioavailability of codeine in itself no.
Thomas29
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Okay thank you and you can not snort or i.v. codeine only take it Orally at least safely and effectively that is why I am saying wtf?
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Jabberwocky
Frumious Bandersnatch
Wrong again. You can IV codeine it is just incredibly dangerous. It can also be used IM. It is prepared for this use in vials actually.
Thomas29
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I said SAFELY??? and effectively which I do not think I.M. if SAFE in like prescribed vials or w/e is not very much better than Orally from what I know.
tentram
Ex-Bluelighter
no, it won't, it will slow down the absorption.
what made you assume so?
source? and why would it matter whether it were pill form, capsule or even syrup? codeine is codeine.
Thomas29
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When snorting Heroin some of the drip is swallowed and very little BUT SOME is metabolized and used by the body would Fat Potentiate it or is a no like Codeine...... How come Morphine is Potentiated by Fat and Codeine is supposed to convert into Morphine is just cause different chemical structures metabolized differently? Oxymorphone and Hydromorphone come with a Label Warnning that High-Fat Meal can increase absorbption by some certain %
Dagda Mochta
Bluelighter
"Abstract
The effects of a high-fat meal on the bioavailability of oxycodone hydrochloride, administered as a recently developed 40 mg controlled-release (CR) tablet or a 20 mg immediate-release (IR) solution, were evaluated in a randomized crossover study in 22 normal male and female subjects. Serial blood samples were collected for 36 h after dosing and analyzed for oxycodone by a validated method using gas chromatography/mass spectrometry. There was no significant food effect with CR oxycodone as judged by 90% confidence interval (CI) analysis of AUC0−∞and Cmax values under fed and fasted conditions. For the IR solution, both oxycodone bioavailability and peak plasma oxycodone concentration were significantly altered by consumption of the high-fat meal, with the mean value for AUC0−∞ increasing to 120% (CI = 109– 132%) and the mean value for Cmax decreasing to 82% (CI = 47–91%) of values observed in the fasted condition. Adverse events reported for both formulations were mostly mild to moderate in severity and typical of those observed with opioids."
http://onlinelibrary.wiley.com/doi/10.1021/js950403a/abstract
Though aparrently codeine is not affected in the same way:
"When 60 mg codeine sulfate was administered 30 minutes after ingesting a high fat/high calorie meal, there was no significant change in the rate and extent of absorption of codeine."
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=12176
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Dagda Mochta
Bluelighter
I find it moderately disturbing to see a moderator state to someone that codeine "can" be IV'd, apparently just for the sake of proving someone "wrong".
I "can" IV melted butter just as much as you "can" IV codeine. What is going on here?